Vivax Malaria and the Potential Role of the Subtelomeric Multigene <i>vir</i> Superfamily
Vivax malaria, caused by <i>Plasmodium vivax</i>, remains a public health concern in Central and Southeast Asia and South America, with more than two billion people at risk of infection. Compared to <i>Plasmodium falciparum</i>, <i>P. vivax</i> is considered a ben...
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Format: | Article |
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MDPI AG
2022-05-01
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Online Access: | https://www.mdpi.com/2076-2607/10/6/1083 |
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author | Youn-Kyoung Goo |
author_facet | Youn-Kyoung Goo |
author_sort | Youn-Kyoung Goo |
collection | DOAJ |
description | Vivax malaria, caused by <i>Plasmodium vivax</i>, remains a public health concern in Central and Southeast Asia and South America, with more than two billion people at risk of infection. Compared to <i>Plasmodium falciparum</i>, <i>P. vivax</i> is considered a benign infection. However, in recent decades, incidences of severe vivax malaria have been confirmed. The <i>P. falciparum</i> erythrocyte membrane protein 1 family encoded by <i>var</i> genes is known as a mediator of severe falciparum malaria by cytoadherence property. Correspondingly, the <i>vir</i> multigene superfamily has been identified as the largest multigene family in <i>P. vivax</i> and is implicated in cytoadherence to endothelial cells and immune response activation. In this review, the functions of <i>vir</i> genes are reviewed in the context of their potential roles in severe vivax malaria. |
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format | Article |
id | doaj.art-1fce3d39ffef412d98f64a076e69ff1f |
institution | Directory Open Access Journal |
issn | 2076-2607 |
language | English |
last_indexed | 2024-03-09T23:00:45Z |
publishDate | 2022-05-01 |
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record_format | Article |
series | Microorganisms |
spelling | doaj.art-1fce3d39ffef412d98f64a076e69ff1f2023-11-23T18:02:41ZengMDPI AGMicroorganisms2076-26072022-05-01106108310.3390/microorganisms10061083Vivax Malaria and the Potential Role of the Subtelomeric Multigene <i>vir</i> SuperfamilyYoun-Kyoung Goo0Department of Parasitology and Tropical Medicine, School of Medicine, Kyungpook National University, Daegu 41944, KoreaVivax malaria, caused by <i>Plasmodium vivax</i>, remains a public health concern in Central and Southeast Asia and South America, with more than two billion people at risk of infection. Compared to <i>Plasmodium falciparum</i>, <i>P. vivax</i> is considered a benign infection. However, in recent decades, incidences of severe vivax malaria have been confirmed. The <i>P. falciparum</i> erythrocyte membrane protein 1 family encoded by <i>var</i> genes is known as a mediator of severe falciparum malaria by cytoadherence property. Correspondingly, the <i>vir</i> multigene superfamily has been identified as the largest multigene family in <i>P. vivax</i> and is implicated in cytoadherence to endothelial cells and immune response activation. In this review, the functions of <i>vir</i> genes are reviewed in the context of their potential roles in severe vivax malaria.https://www.mdpi.com/2076-2607/10/6/1083<i>Plasmodium vivax</i><i>vir</i> genesevere vivax malariacytoadherenceimmune response |
spellingShingle | Youn-Kyoung Goo Vivax Malaria and the Potential Role of the Subtelomeric Multigene <i>vir</i> Superfamily Microorganisms <i>Plasmodium vivax</i> <i>vir</i> gene severe vivax malaria cytoadherence immune response |
title | Vivax Malaria and the Potential Role of the Subtelomeric Multigene <i>vir</i> Superfamily |
title_full | Vivax Malaria and the Potential Role of the Subtelomeric Multigene <i>vir</i> Superfamily |
title_fullStr | Vivax Malaria and the Potential Role of the Subtelomeric Multigene <i>vir</i> Superfamily |
title_full_unstemmed | Vivax Malaria and the Potential Role of the Subtelomeric Multigene <i>vir</i> Superfamily |
title_short | Vivax Malaria and the Potential Role of the Subtelomeric Multigene <i>vir</i> Superfamily |
title_sort | vivax malaria and the potential role of the subtelomeric multigene i vir i superfamily |
topic | <i>Plasmodium vivax</i> <i>vir</i> gene severe vivax malaria cytoadherence immune response |
url | https://www.mdpi.com/2076-2607/10/6/1083 |
work_keys_str_mv | AT younkyounggoo vivaxmalariaandthepotentialroleofthesubtelomericmultigeneivirisuperfamily |