Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys
The rapid degradation of magnesium (Mg)-based implants in physiological environment limits its clinical applications, and alloying treatment is an effective way to regulate the degradation rate of Mg-based materials. In the present study, three Mg alloys, including Mg-0.8Ca (denoted as ZQ), Mg-0.8Ca...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-12-01
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| Series: | Journal of Magnesium and Alloys |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956721001328 |
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| author | Hewei Chen Bo Yuan Rui Zhao Xiao Yang Zhanwen Xiao Antoniac Aurora Bita Ana Iulia Xiangdong Zhu Antoniac Vasile Iulian Xingdong Zhang |
| author_facet | Hewei Chen Bo Yuan Rui Zhao Xiao Yang Zhanwen Xiao Antoniac Aurora Bita Ana Iulia Xiangdong Zhu Antoniac Vasile Iulian Xingdong Zhang |
| author_sort | Hewei Chen |
| collection | DOAJ |
| description | The rapid degradation of magnesium (Mg)-based implants in physiological environment limits its clinical applications, and alloying treatment is an effective way to regulate the degradation rate of Mg-based materials. In the present study, three Mg alloys, including Mg-0.8Ca (denoted as ZQ), Mg-0.8Ca-5Zn-1.5Ag (denoted as ZQ71) and Mg-0.8Ca-5Zn-2.5Ag (denoted as ZQ63), were fabricated by alloying with calcium (Ca), zinc (Zn) and silver (Ag). The results obtained from electrochemical corrosion tests and in vitro degradation evaluation demonstrated that the three Mg alloys exhibited distinct corrosion resistance, and ZQ71 exhibited the lowest degradation rate in vitro among them. After addition of Zn and Ag, the antibacterial potential of Mg alloys was also enhanced. The in vitro cell experiments showed that all the three Mg alloys had good biocompatibility. After implantation in a rat femoral defect, ZQ71 showed significantly higher osteogenic activity and bone substitution rate than ZQ63 and ZQ, due to its higher corrosion resistance as well as the stimulatory effects of the released metallic ions. In addition, the average daily degradation rate of each Mg alloy in vivo was significantly higher than that in vitro, as could be due to the implantation site located in the highly vascularized trabecular region. Importantly, the correlations between the in vitro and in vivo degradation parameters of the Mg alloys were systematically analyzed to find out the potential predictors of the in vivo degradation performance of the materials. The current work not only evaluated the clinical potential of the three biodegradable Mg alloys as bone grafts but also provided a feasible approach for predicting the in vivo degradation behavior of biodegradable materials. |
| first_indexed | 2024-04-11T00:54:05Z |
| format | Article |
| id | doaj.art-1fcffb96691b405ab53fb5d8731539df |
| institution | Directory Open Access Journal |
| issn | 2213-9567 |
| language | English |
| last_indexed | 2025-03-22T04:23:36Z |
| publishDate | 2022-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj.art-1fcffb96691b405ab53fb5d8731539df2024-04-28T06:37:44ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672022-12-01101233803396Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloysHewei Chen0Bo Yuan1Rui Zhao2Xiao Yang3Zhanwen Xiao4Antoniac Aurora5Bita Ana Iulia6Xiangdong Zhu7Antoniac Vasile Iulian8Xingdong Zhang9National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaFaculty of Materials Science and Engineering, University Politehnica of Bucharest, Bucharest 060042, RomaniaFaculty of Materials Science and Engineering, University Politehnica of Bucharest, Bucharest 060042, RomaniaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; Corresponding authors.Faculty of Materials Science and Engineering, University Politehnica of Bucharest, Bucharest 060042, Romania; Academy of Romanian Scientists, Bucharest 050094, Romania; Corresponding authors.National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaThe rapid degradation of magnesium (Mg)-based implants in physiological environment limits its clinical applications, and alloying treatment is an effective way to regulate the degradation rate of Mg-based materials. In the present study, three Mg alloys, including Mg-0.8Ca (denoted as ZQ), Mg-0.8Ca-5Zn-1.5Ag (denoted as ZQ71) and Mg-0.8Ca-5Zn-2.5Ag (denoted as ZQ63), were fabricated by alloying with calcium (Ca), zinc (Zn) and silver (Ag). The results obtained from electrochemical corrosion tests and in vitro degradation evaluation demonstrated that the three Mg alloys exhibited distinct corrosion resistance, and ZQ71 exhibited the lowest degradation rate in vitro among them. After addition of Zn and Ag, the antibacterial potential of Mg alloys was also enhanced. The in vitro cell experiments showed that all the three Mg alloys had good biocompatibility. After implantation in a rat femoral defect, ZQ71 showed significantly higher osteogenic activity and bone substitution rate than ZQ63 and ZQ, due to its higher corrosion resistance as well as the stimulatory effects of the released metallic ions. In addition, the average daily degradation rate of each Mg alloy in vivo was significantly higher than that in vitro, as could be due to the implantation site located in the highly vascularized trabecular region. Importantly, the correlations between the in vitro and in vivo degradation parameters of the Mg alloys were systematically analyzed to find out the potential predictors of the in vivo degradation performance of the materials. The current work not only evaluated the clinical potential of the three biodegradable Mg alloys as bone grafts but also provided a feasible approach for predicting the in vivo degradation behavior of biodegradable materials.http://www.sciencedirect.com/science/article/pii/S2213956721001328Mg alloysDegradabilityAntibacterial propertyOsteogenic abilityBone defect repair |
| spellingShingle | Hewei Chen Bo Yuan Rui Zhao Xiao Yang Zhanwen Xiao Antoniac Aurora Bita Ana Iulia Xiangdong Zhu Antoniac Vasile Iulian Xingdong Zhang Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys Journal of Magnesium and Alloys Mg alloys Degradability Antibacterial property Osteogenic ability Bone defect repair |
| title | Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys |
| title_full | Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys |
| title_fullStr | Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys |
| title_full_unstemmed | Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys |
| title_short | Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys |
| title_sort | evaluation on the corrosion resistance antibacterial property and osteogenic activity of biodegradable mg ca and mg ca zn ag alloys |
| topic | Mg alloys Degradability Antibacterial property Osteogenic ability Bone defect repair |
| url | http://www.sciencedirect.com/science/article/pii/S2213956721001328 |
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