Inhibitory effects of maslinic acid upon human esophagus, stomach and pancreatic cancer cells
Apoptotic, anti-invasive and anti-migratory effects of maslinic acid (MA) at 4, 8, or 16 µM in human esophageal squamous cancer cell line, OE33; gastric cancer cell line, SGC-7901; and pancreatic cancer cell line, Panc-1, were examined. MA treatments inhibited OE33 and SGC-7901 cells growth at 21–66...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-11-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464614002795 |
| _version_ | 1818937013776154624 |
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| author | Chun-che Lin Sheng-lei Yan Mei-chin Yin |
| author_facet | Chun-che Lin Sheng-lei Yan Mei-chin Yin |
| author_sort | Chun-che Lin |
| collection | DOAJ |
| description | Apoptotic, anti-invasive and anti-migratory effects of maslinic acid (MA) at 4, 8, or 16 µM in human esophageal squamous cancer cell line, OE33; gastric cancer cell line, SGC-7901; and pancreatic cancer cell line, Panc-1, were examined. MA treatments inhibited OE33 and SGC-7901 cells growth at 21–66% and 32–75%, respectively; but lowered Panc-1 viability at 13–27% only. MA treatments increased cleaved caspase-3 and Bax expression, and raised caspase-3 and caspase-8 activities in OE33 and SGC-7901 cells. MA treatments also increased DNA fragmentation and decreased reactive oxygen species production in these two cell lines. MA treatments declined invasion and migration in OE33 and SGC-7901 cells, and lowered vascular endothelial growth factor and transforming growth factor-beta1 levels in these cells. MA suppressed hypoxia-inducible factor-1alpha, matrix metalloproteinase (MMP)-2 and MMP-9 expression in OE33 and SGC-7901 cells. These findings indicated that this triterpene was a potent agent against esophagus and stomach cancers. |
| first_indexed | 2024-12-20T05:45:13Z |
| format | Article |
| id | doaj.art-1fd0496ef0fe47e1aef26a9918172105 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T05:45:13Z |
| publishDate | 2014-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-1fd0496ef0fe47e1aef26a99181721052022-12-21T19:51:20ZengElsevierJournal of Functional Foods1756-46462014-11-0111581588Inhibitory effects of maslinic acid upon human esophagus, stomach and pancreatic cancer cellsChun-che Lin0Sheng-lei Yan1Mei-chin Yin2Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung City, Taiwan; School of Medicine, Chung Shan Medical University, Taichung City, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Chang Bing Show-Chwan Memorial Hospital, Changhua County, TaiwanDepartment of Nutrition, China Medical University, Taichung City, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung City, Taiwan; Corresponding author. Tel.: +886 4 22053366 ext. 7510; fax: +886 4 22062891.Apoptotic, anti-invasive and anti-migratory effects of maslinic acid (MA) at 4, 8, or 16 µM in human esophageal squamous cancer cell line, OE33; gastric cancer cell line, SGC-7901; and pancreatic cancer cell line, Panc-1, were examined. MA treatments inhibited OE33 and SGC-7901 cells growth at 21–66% and 32–75%, respectively; but lowered Panc-1 viability at 13–27% only. MA treatments increased cleaved caspase-3 and Bax expression, and raised caspase-3 and caspase-8 activities in OE33 and SGC-7901 cells. MA treatments also increased DNA fragmentation and decreased reactive oxygen species production in these two cell lines. MA treatments declined invasion and migration in OE33 and SGC-7901 cells, and lowered vascular endothelial growth factor and transforming growth factor-beta1 levels in these cells. MA suppressed hypoxia-inducible factor-1alpha, matrix metalloproteinase (MMP)-2 and MMP-9 expression in OE33 and SGC-7901 cells. These findings indicated that this triterpene was a potent agent against esophagus and stomach cancers.http://www.sciencedirect.com/science/article/pii/S1756464614002795Maslinic acidGI tract cancer cellsApoptosisInvasionMigration |
| spellingShingle | Chun-che Lin Sheng-lei Yan Mei-chin Yin Inhibitory effects of maslinic acid upon human esophagus, stomach and pancreatic cancer cells Journal of Functional Foods Maslinic acid GI tract cancer cells Apoptosis Invasion Migration |
| title | Inhibitory effects of maslinic acid upon human esophagus, stomach and pancreatic cancer cells |
| title_full | Inhibitory effects of maslinic acid upon human esophagus, stomach and pancreatic cancer cells |
| title_fullStr | Inhibitory effects of maslinic acid upon human esophagus, stomach and pancreatic cancer cells |
| title_full_unstemmed | Inhibitory effects of maslinic acid upon human esophagus, stomach and pancreatic cancer cells |
| title_short | Inhibitory effects of maslinic acid upon human esophagus, stomach and pancreatic cancer cells |
| title_sort | inhibitory effects of maslinic acid upon human esophagus stomach and pancreatic cancer cells |
| topic | Maslinic acid GI tract cancer cells Apoptosis Invasion Migration |
| url | http://www.sciencedirect.com/science/article/pii/S1756464614002795 |
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