Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress

Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress

Abstract Background Mutations in genes associated with homologous recombination (HR) increase an individual’s risk of developing triple-negative breast cancer (TNBC). Although known for their role in repairing dsDNA breaks, HR repair elements also stabilize and restart stalled replication forks. Ess...

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Bibliographic Details
Main Authors: Scott J. Pearson, Jessica Elswood, Rola Barhoumi, Brittini Ming-Whitfield, Monique Rijnkels, Weston W. Porter
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Tumor suppressor
Genetic instability
SIM2
Replication stress
Online Access:http://link.springer.com/article/10.1186/s13058-019-1207-z

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