Relationship between the triglyceride–glucose index and coronary artery calcification in asymptomatic, non-diabetic patients undergoing maintenance hemodialysis
AbstractObjective Coronary artery calcification (CAC) is positively and independently associated with cardiovascular disease (CVD) in patients undergoing maintenance hemodialysis (MHD). Insulin resistance is independently associated with CAC and is an important risk factor for CVD. The triglyceride–...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2200849 |
| _version_ | 1797658490158710784 |
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| author | Hong Ding Jinhua Zhu Ying Tian Li Xu Lei Song Ying Shi Dongxing Mu Ruoxin Chen Hong Liu Bicheng Liu |
| author_facet | Hong Ding Jinhua Zhu Ying Tian Li Xu Lei Song Ying Shi Dongxing Mu Ruoxin Chen Hong Liu Bicheng Liu |
| author_sort | Hong Ding |
| collection | DOAJ |
| description | AbstractObjective Coronary artery calcification (CAC) is positively and independently associated with cardiovascular disease (CVD) in patients undergoing maintenance hemodialysis (MHD). Insulin resistance is independently associated with CAC and is an important risk factor for CVD. The triglyceride–glucose (TyG) index is a reliable biomarker of insulin resistance. This cross-sectional, observational study aimed to investigate the relationship between the TyG index and CAC in asymptomatic non-diabetic patients undergoing MHD.Methods The quantitative coronary artery calcification score (CACS) was calculated and expressed using the Agatston score. The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Multiple Poisson regression analysis, Spearman correlation analysis, and receiver operating characteristic (ROC) curves were used to investigate the relationship between the TyG index and CAC.Results The 151 patients were divided into three groups according to the tertiles of the TyG index. With an increase in the TyG index, the CACS significantly increased (Spearman’s rho = 0.414, p < 0.001). Poisson regression analysis indicated that the TyG index was independently related to the presence of CAC (prevalence ratio, 1.281 [95% confidence interval, 1.121–1.465], p < 0.001). Furthermore, ROC curve analysis showed that the TyG index was of value in predicting the CAC in asymptomatic non-diabetic patients undergoing MHD, with an area under the curve of 0.667 (p = 0.010).Conclusion The TyG index is independently related to the presence of CAC in asymptomatic, non-diabetic patients undergoing MHD. |
| first_indexed | 2024-03-11T17:59:41Z |
| format | Article |
| id | doaj.art-1fd3027e534c4841929111dd8a2e9ba3 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-03-11T17:59:41Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-1fd3027e534c4841929111dd8a2e9ba32023-10-17T09:23:24ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2200849Relationship between the triglyceride–glucose index and coronary artery calcification in asymptomatic, non-diabetic patients undergoing maintenance hemodialysisHong Ding0Jinhua Zhu1Ying Tian2Li Xu3Lei Song4Ying Shi5Dongxing Mu6Ruoxin Chen7Hong Liu8Bicheng Liu9Institute of Nephrology, People’s Hospital of Yangzhong city, Zhenjiang, Jiangsu Province, ChinaInstitute of Nephrology, People’s Hospital of Yangzhong city, Zhenjiang, Jiangsu Province, ChinaInstitute of Nephrology, People’s Hospital of Yangzhong city, Zhenjiang, Jiangsu Province, ChinaInstitute of Nephrology, People’s Hospital of Yangzhong city, Zhenjiang, Jiangsu Province, ChinaInstitute of Nephrology, People’s Hospital of Yangzhong city, Zhenjiang, Jiangsu Province, ChinaInstitute of Nephrology, People’s Hospital of Yangzhong city, Zhenjiang, Jiangsu Province, ChinaInstitute of Nephrology, People’s Hospital of Yangzhong city, Zhenjiang, Jiangsu Province, ChinaInstitute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, Jiangsu Province, ChinaInstitute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, Jiangsu Province, ChinaInstitute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, Jiangsu Province, ChinaAbstractObjective Coronary artery calcification (CAC) is positively and independently associated with cardiovascular disease (CVD) in patients undergoing maintenance hemodialysis (MHD). Insulin resistance is independently associated with CAC and is an important risk factor for CVD. The triglyceride–glucose (TyG) index is a reliable biomarker of insulin resistance. This cross-sectional, observational study aimed to investigate the relationship between the TyG index and CAC in asymptomatic non-diabetic patients undergoing MHD.Methods The quantitative coronary artery calcification score (CACS) was calculated and expressed using the Agatston score. The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Multiple Poisson regression analysis, Spearman correlation analysis, and receiver operating characteristic (ROC) curves were used to investigate the relationship between the TyG index and CAC.Results The 151 patients were divided into three groups according to the tertiles of the TyG index. With an increase in the TyG index, the CACS significantly increased (Spearman’s rho = 0.414, p < 0.001). Poisson regression analysis indicated that the TyG index was independently related to the presence of CAC (prevalence ratio, 1.281 [95% confidence interval, 1.121–1.465], p < 0.001). Furthermore, ROC curve analysis showed that the TyG index was of value in predicting the CAC in asymptomatic non-diabetic patients undergoing MHD, with an area under the curve of 0.667 (p = 0.010).Conclusion The TyG index is independently related to the presence of CAC in asymptomatic, non-diabetic patients undergoing MHD.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2200849Triglyceride–glucose indexcardiovascular diseasecoronary artery calcificationnon-diabeticmaintenance hemodialysis |
| spellingShingle | Hong Ding Jinhua Zhu Ying Tian Li Xu Lei Song Ying Shi Dongxing Mu Ruoxin Chen Hong Liu Bicheng Liu Relationship between the triglyceride–glucose index and coronary artery calcification in asymptomatic, non-diabetic patients undergoing maintenance hemodialysis Renal Failure Triglyceride–glucose index cardiovascular disease coronary artery calcification non-diabetic maintenance hemodialysis |
| title | Relationship between the triglyceride–glucose index and coronary artery calcification in asymptomatic, non-diabetic patients undergoing maintenance hemodialysis |
| title_full | Relationship between the triglyceride–glucose index and coronary artery calcification in asymptomatic, non-diabetic patients undergoing maintenance hemodialysis |
| title_fullStr | Relationship between the triglyceride–glucose index and coronary artery calcification in asymptomatic, non-diabetic patients undergoing maintenance hemodialysis |
| title_full_unstemmed | Relationship between the triglyceride–glucose index and coronary artery calcification in asymptomatic, non-diabetic patients undergoing maintenance hemodialysis |
| title_short | Relationship between the triglyceride–glucose index and coronary artery calcification in asymptomatic, non-diabetic patients undergoing maintenance hemodialysis |
| title_sort | relationship between the triglyceride glucose index and coronary artery calcification in asymptomatic non diabetic patients undergoing maintenance hemodialysis |
| topic | Triglyceride–glucose index cardiovascular disease coronary artery calcification non-diabetic maintenance hemodialysis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2200849 |
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