Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells.

Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells.

Latency reversal agents (LRA) variably induce HIV re-expression in CD4 T cells but reservoirs are not cleared. Whether HIV epitope presentation is similar between latency reversal and initial infection of CD4 T cells is unknown yet crucial to define immune responses able to detect HIV-infected CD4 T...

Full description

Bibliographic Details
Main Authors:	Julie Boucau, Jishnu Das, Neelambari Joshi, Sylvie Le Gall
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2020-03-01
Series:	PLoS Pathogens
Online Access:	https://doi.org/10.1371/journal.ppat.1008442

Similar Items

Latency-reversing agents and cellular activation affect antigen processing in primary CD4 T cells
by: J. Boucau, et al.
Published: (2015-12-01)

Drug-induced modulation of cellular activation during latency reversal changes antigen processing and peptide presentation in primary CD4 T cells
by: J. Boucau, et al.
Published: (2017-12-01)

Diverse Impacts of HIV Latency-Reversing Agents on CD8+ T-Cell Function: Implications for HIV Cure
by: Genevieve Tyndale Clutton, et al.
Published: (2018-06-01)

HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells
by: Blandine Monel, et al.
Published: (2019-04-01)

23 Understanding the effects of latency reversing agents on HIV RNA splicing: implications for latency reversal
by: T.M. Mota, et al.
Published: (2016-07-01)

OP 2.8 – 00193 Enhancing PKC Modulator HIV Latency Reversing Agents
by: M. Marsden, et al.
Published: (2022-12-01)

Memory CD4+ T cell subsets show differential responses to HIV latency-reversing agents
by: D.A. Kulpa, et al.
Published: (2015-12-01)

Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations.
by: Judith Grau-Expósito, et al.
Published: (2019-08-01)

A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.
by: Rujapak Sutiwisesak, et al.
Published: (2020-10-01)

Combinatorial latency reversal activity of inhibitor of apoptosis antagonists with mechanistically distinct classes of HIV latency reversal agents
by: Shane D. Falcinelli, et al.
Published: (2019-12-01)

Alteration of HIV epitope processing and presentation by HIV protease inhibitors
by: Kourjian G, et al.
Published: (2012-09-01)

Optimisation of Smac mimetics as HIV-1 latency reversing agents
by: L. Pache, et al.
Published: (2019-12-01)

Reanalysis of Gene Expression Profiles of CD4+ T Cells Treated with HIV-1 Latency Reversal Agents
by: Antonio Victor Campos Coelho, et al.
Published: (2020-09-01)

Histone deacetylase inhibitors induce transcription of unspliced but not multiply spliced HIV-1 RNA from proviral genomes during latency reversal, affecting antigen presentation and detection by CD8+ T cells
by: T. Mota, et al.
Published: (2019-12-01)

Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design
by: Marijana Rucevic, et al.
Published: (2014-08-01)

Optimal Control of an HIV Model with Gene Therapy and Latency Reversing Agents
by: Zachary Abernathy, et al.
Published: (2021-11-01)

OP 2.7 – 00057 The latency reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific CD8+ T-cells
by: D.C. Copertino, et al.
Published: (2022-12-01)

Effect of HIV infection on the expression and the activity of the proteasome in primary CD4 T cells
by: Boucau J, et al.
Published: (2012-09-01)

Approaches to discover latency-reversing agents
Published: (2015-12-01)

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4⁺ T-Cells to Recognition by Cytotoxic T-Lymphocytes
by: O’Connor, Rachel, et al.
Published: (2017)

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.
by: R Brad Jones, et al.
Published: (2016-04-01)

The SMAC mimetic AZD5582 reverses HIV latency as a single agent in resting primary CD4+ T cells
by: G. Sampey, et al.
Published: (2019-07-01)

Unprimed CD8 lymphocytes promote the establishment of HIV latency in CD4 T cells
by: L. Franchitti, et al.
Published: (2019-12-01)

HIV latency reversing agents act through Tat post translational modifications
by: Georges Khoury, et al.
Published: (2018-05-01)

Novel use of alprazolam as a potential HIV-1 latency reversing agent
by: W. Elbezanti, et al.
Published: (2017-12-01)

Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
by: Hany Zekaria Meås, et al.
Published: (2020-01-01)

Differential effects of HIV latency-reversing agents on T cell phenotype and function: implications for HIV cure
by: G. Clutton, et al.
Published: (2015-12-01)

The Effect of Latency Reversal Agents on Primary CD8+ T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus Eradication
by: Victoria E. Walker-Sperling, et al.
Published: (2016-06-01)

Maraviroc reactivates HIV with a potency similar to that of other latency reversing drugs without inducing toxicity in CD8 T cells
by: S. Moreno, et al.
Published: (2019-12-01)

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells.
by: Zachary B Davis, et al.
Published: (2016-02-01)

Co-culture of T-cells with dendritic cells facilitates HIV latency in proliferating CD4+ T-cells: implications for the establishment and reversal of latency
by: N. Kumar, et al.
Published: (2015-12-01)

Insights into mechanisms of HIV reactivation from latency using RNA-Seq gene expression profiling in CD4+ T cells and their maturation subsets following treatment with latency reversing agents.
by: N. Beliakova-Bethell, et al.
Published: (2017-12-01)

OP 8.2 – 00033 Interleukin-2 administration is a potent latency reversal agent in people with treated HIV infection
by: M. Freeman, et al.
Published: (2022-12-01)

Discovering the Mechanisms of Oleodaphnone as a Potential HIV Latency-Reversing Agent by Transcriptome Profiling
by: Shifei Li, et al.
Published: (2023-04-01)

Molecular Modeling and Synthesis of New HIV Latency-Reversing Agents Targeting the Lymphatic System
by: Beatriz Meduqui Rodrigues, et al.
Published: (2022-11-01)

Epigenetic Regulation of HIV-1 Sense and Antisense Transcription in Response to Latency-Reversing Agents
by: Rui Li, et al.
Published: (2023-01-01)

HIV Latency Reversing Agents have diverse effects on Natural Killer Cell Function
by: Carolina Garrido, et al.
Published: (2016-09-01)

Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA
by: Jared P. Taylor, et al.
Published: (2020-12-01)

Tissue-specific effects of latency-reversing agents on HIV transcriptional blocks in gut and blood
by: S. Telwatte, et al.
Published: (2019-07-01)

O3 Heme-arginate as a latency-reversing agent for HIV-1 cure
by: Michaela Madlenakova, et al.
Published: (2017-09-01)