The Impact of Non-coding RNAs in the Epithelial to Mesenchymal Transition
Epithelial to mesenchymal transition (EMT) is a course of action that enables a polarized epithelial cell to undertake numerous biochemical alterations that allow it to adopt features of mesenchymal cells such as high migratory ability, invasive properties, resistance to apoptosis, and importantly h...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.665199/full |
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| author | Bashdar Mahmud Hussen Hamed Shoorei Mahdi Mohaqiq Marcel E. Dinger Hazha Jamal Hidayat Mohammad Taheri Soudeh Ghafouri-Fard |
| author_facet | Bashdar Mahmud Hussen Hamed Shoorei Mahdi Mohaqiq Marcel E. Dinger Hazha Jamal Hidayat Mohammad Taheri Soudeh Ghafouri-Fard |
| author_sort | Bashdar Mahmud Hussen |
| collection | DOAJ |
| description | Epithelial to mesenchymal transition (EMT) is a course of action that enables a polarized epithelial cell to undertake numerous biochemical alterations that allow it to adopt features of mesenchymal cells such as high migratory ability, invasive properties, resistance to apoptosis, and importantly higher-order formation of extracellular matrix elements. EMT has important roles in implantation and gastrulation of the embryo, inflammatory reactions and fibrosis, and transformation of cancer cells, their invasiveness and metastatic ability. Regarding the importance of EMT in the invasive progression of cancer, this process has been well studies in in this context. Non-coding RNAs (ncRNAs) have been shown to exert critical function in the regulation of cellular processes that are involved in the EMT. These processes include regulation of some transcription factors namely SNAI1 and SNAI2, ZEB1 and ZEB2, Twist, and E12/E47, modulation of chromatin configuration, alternative splicing, and protein stability and subcellular location of proteins. In the present paper, we describe the influence of ncRNAs including microRNAs and long non-coding RNAs in the EMT process and their application as biomarkers for this process and cancer progression and their potential as therapeutic targets. |
| first_indexed | 2024-12-13T18:59:25Z |
| format | Article |
| id | doaj.art-1fd463e3d90143fd887dbaadab2fcea4 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-13T18:59:25Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-1fd463e3d90143fd887dbaadab2fcea42022-12-21T23:34:43ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-03-01810.3389/fmolb.2021.665199665199The Impact of Non-coding RNAs in the Epithelial to Mesenchymal TransitionBashdar Mahmud Hussen0Hamed Shoorei1Mahdi Mohaqiq2Marcel E. Dinger3Hazha Jamal Hidayat4Mohammad Taheri5Soudeh Ghafouri-Fard6Pharmacognosy Department, College of Pharmacy, Hawler Medical University, Erbil, IraqDepartment of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, IranWake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC, United StatesSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, AustraliaDepartment of Biology, College of Education, Salahaddin University-Erbil, Erbil, IraqUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, IranEpithelial to mesenchymal transition (EMT) is a course of action that enables a polarized epithelial cell to undertake numerous biochemical alterations that allow it to adopt features of mesenchymal cells such as high migratory ability, invasive properties, resistance to apoptosis, and importantly higher-order formation of extracellular matrix elements. EMT has important roles in implantation and gastrulation of the embryo, inflammatory reactions and fibrosis, and transformation of cancer cells, their invasiveness and metastatic ability. Regarding the importance of EMT in the invasive progression of cancer, this process has been well studies in in this context. Non-coding RNAs (ncRNAs) have been shown to exert critical function in the regulation of cellular processes that are involved in the EMT. These processes include regulation of some transcription factors namely SNAI1 and SNAI2, ZEB1 and ZEB2, Twist, and E12/E47, modulation of chromatin configuration, alternative splicing, and protein stability and subcellular location of proteins. In the present paper, we describe the influence of ncRNAs including microRNAs and long non-coding RNAs in the EMT process and their application as biomarkers for this process and cancer progression and their potential as therapeutic targets.https://www.frontiersin.org/articles/10.3389/fmolb.2021.665199/fulllncRNAmiRNAepithelial to mesenchymal transitionexpressionbiomarker |
| spellingShingle | Bashdar Mahmud Hussen Hamed Shoorei Mahdi Mohaqiq Marcel E. Dinger Hazha Jamal Hidayat Mohammad Taheri Soudeh Ghafouri-Fard The Impact of Non-coding RNAs in the Epithelial to Mesenchymal Transition Frontiers in Molecular Biosciences lncRNA miRNA epithelial to mesenchymal transition expression biomarker |
| title | The Impact of Non-coding RNAs in the Epithelial to Mesenchymal Transition |
| title_full | The Impact of Non-coding RNAs in the Epithelial to Mesenchymal Transition |
| title_fullStr | The Impact of Non-coding RNAs in the Epithelial to Mesenchymal Transition |
| title_full_unstemmed | The Impact of Non-coding RNAs in the Epithelial to Mesenchymal Transition |
| title_short | The Impact of Non-coding RNAs in the Epithelial to Mesenchymal Transition |
| title_sort | impact of non coding rnas in the epithelial to mesenchymal transition |
| topic | lncRNA miRNA epithelial to mesenchymal transition expression biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.665199/full |
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