Update on the Cognitive Presentations of iNPH for Clinicians
This mini-review focuses on cognitive impairment in iNPH. This symptom is one of the characteristic triad of symptoms in a condition long considered to be the only treatable dementia. We present an update on recent developments in clinical, neuropsychological, neuroimaging and biomarker aspects. Sig...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.894617/full |
| _version_ | 1811289598649696256 |
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| author | Tobias Langheinrich Tobias Langheinrich Cliff Chen Owen Thomas Owen Thomas |
| author_facet | Tobias Langheinrich Tobias Langheinrich Cliff Chen Owen Thomas Owen Thomas |
| author_sort | Tobias Langheinrich |
| collection | DOAJ |
| description | This mini-review focuses on cognitive impairment in iNPH. This symptom is one of the characteristic triad of symptoms in a condition long considered to be the only treatable dementia. We present an update on recent developments in clinical, neuropsychological, neuroimaging and biomarker aspects. Significant advances in our understanding have been made, notably regarding biomarkers, but iNPH remains a difficult diagnosis. Stronger evidence for permanent surgical treatment is emerging but selection for treatment remains challenging, particularly with regards to cognitive presentations. Encouragingly, there has been increasing interest in iNPH, but more research is required to better define the underlying pathology and delineate it from overlapping conditions, in order to inform best practise for the clinician managing the cognitively impaired patient. In the meantime, we strongly encourage a multidisciplinary approach and a structured service pathway to maximise patient benefit. |
| first_indexed | 2024-04-13T03:57:24Z |
| format | Article |
| id | doaj.art-1fd4a077d4184cd6b61a9e8a0e3f7f53 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T03:57:24Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-1fd4a077d4184cd6b61a9e8a0e3f7f532022-12-22T03:03:34ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-07-011310.3389/fneur.2022.894617894617Update on the Cognitive Presentations of iNPH for CliniciansTobias Langheinrich0Tobias Langheinrich1Cliff Chen2Owen Thomas3Owen Thomas4Department of Neurology, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, United KingdomDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Manchester, United KingdomDepartment of Neuropsychology, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, United KingdomDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Manchester, United KingdomDepartment of Neuroradiology, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, United KingdomThis mini-review focuses on cognitive impairment in iNPH. This symptom is one of the characteristic triad of symptoms in a condition long considered to be the only treatable dementia. We present an update on recent developments in clinical, neuropsychological, neuroimaging and biomarker aspects. Significant advances in our understanding have been made, notably regarding biomarkers, but iNPH remains a difficult diagnosis. Stronger evidence for permanent surgical treatment is emerging but selection for treatment remains challenging, particularly with regards to cognitive presentations. Encouragingly, there has been increasing interest in iNPH, but more research is required to better define the underlying pathology and delineate it from overlapping conditions, in order to inform best practise for the clinician managing the cognitively impaired patient. In the meantime, we strongly encourage a multidisciplinary approach and a structured service pathway to maximise patient benefit.https://www.frontiersin.org/articles/10.3389/fneur.2022.894617/fullIdiopathic Normal Pressure HydrocephalusdementiaAlzheimer's diseaseLewy body diseaseprogressive supranuclear palsycorticobasal degeneration |
| spellingShingle | Tobias Langheinrich Tobias Langheinrich Cliff Chen Owen Thomas Owen Thomas Update on the Cognitive Presentations of iNPH for Clinicians Frontiers in Neurology Idiopathic Normal Pressure Hydrocephalus dementia Alzheimer's disease Lewy body disease progressive supranuclear palsy corticobasal degeneration |
| title | Update on the Cognitive Presentations of iNPH for Clinicians |
| title_full | Update on the Cognitive Presentations of iNPH for Clinicians |
| title_fullStr | Update on the Cognitive Presentations of iNPH for Clinicians |
| title_full_unstemmed | Update on the Cognitive Presentations of iNPH for Clinicians |
| title_short | Update on the Cognitive Presentations of iNPH for Clinicians |
| title_sort | update on the cognitive presentations of inph for clinicians |
| topic | Idiopathic Normal Pressure Hydrocephalus dementia Alzheimer's disease Lewy body disease progressive supranuclear palsy corticobasal degeneration |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.894617/full |
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