Syntheses and anti-microbial evaluation of new quinoline scaffold derived pyrimidine derivatives
A series of diversely substituted chalcones derived from a quinoline scaffold, e.g. (E)-3-(2-chloroquinolin-3-yl)-1-(2-hydroxyphenyl) prop-2-en-1-one and its pyrimidine analogues e.g. 2-[2-amino-6-(2-chloroquinolin-3-yl)-5,6-dihydropyrimidin-4-yl]phenols have been prepared by condensation of 2-chlor...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535211001614 |
| _version_ | 1819195169737539584 |
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| author | Shikha S. Dave Anjali M. Rahatgaonkar |
| author_facet | Shikha S. Dave Anjali M. Rahatgaonkar |
| author_sort | Shikha S. Dave |
| collection | DOAJ |
| description | A series of diversely substituted chalcones derived from a quinoline scaffold, e.g. (E)-3-(2-chloroquinolin-3-yl)-1-(2-hydroxyphenyl) prop-2-en-1-one and its pyrimidine analogues e.g. 2-[2-amino-6-(2-chloroquinolin-3-yl)-5,6-dihydropyrimidin-4-yl]phenols have been prepared by condensation of 2-chloro-3-formyl quinoline with differently substituted 2-hydroxy acetophenones and further treatment with guanidine carbonate. All the newly synthesized compounds have been evaluated for their in vitro growth inhibitory activity against Escherichia coli, Pseudomonas vulgaris, Bacillus subtilis, Staphylococcus aureus, Staphylococcus typhi, Candida albicans, Aspergillus niger and Pseudomonas chrysogenum. |
| first_indexed | 2024-12-23T02:08:29Z |
| format | Article |
| id | doaj.art-1fd6f7881ffd4b179561d972bb7e63cf |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-23T02:08:29Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-1fd6f7881ffd4b179561d972bb7e63cf2022-12-21T18:03:50ZengElsevierArabian Journal of Chemistry1878-53522016-09-019S1S451S45610.1016/j.arabjc.2011.06.009Syntheses and anti-microbial evaluation of new quinoline scaffold derived pyrimidine derivativesShikha S. DaveAnjali M. RahatgaonkarA series of diversely substituted chalcones derived from a quinoline scaffold, e.g. (E)-3-(2-chloroquinolin-3-yl)-1-(2-hydroxyphenyl) prop-2-en-1-one and its pyrimidine analogues e.g. 2-[2-amino-6-(2-chloroquinolin-3-yl)-5,6-dihydropyrimidin-4-yl]phenols have been prepared by condensation of 2-chloro-3-formyl quinoline with differently substituted 2-hydroxy acetophenones and further treatment with guanidine carbonate. All the newly synthesized compounds have been evaluated for their in vitro growth inhibitory activity against Escherichia coli, Pseudomonas vulgaris, Bacillus subtilis, Staphylococcus aureus, Staphylococcus typhi, Candida albicans, Aspergillus niger and Pseudomonas chrysogenum.http://www.sciencedirect.com/science/article/pii/S1878535211001614QuinolineChalconePyrimidineAntimicrobial activityAnti-fungal activity |
| spellingShingle | Shikha S. Dave Anjali M. Rahatgaonkar Syntheses and anti-microbial evaluation of new quinoline scaffold derived pyrimidine derivatives Arabian Journal of Chemistry Quinoline Chalcone Pyrimidine Antimicrobial activity Anti-fungal activity |
| title | Syntheses and anti-microbial evaluation of new quinoline scaffold derived pyrimidine derivatives |
| title_full | Syntheses and anti-microbial evaluation of new quinoline scaffold derived pyrimidine derivatives |
| title_fullStr | Syntheses and anti-microbial evaluation of new quinoline scaffold derived pyrimidine derivatives |
| title_full_unstemmed | Syntheses and anti-microbial evaluation of new quinoline scaffold derived pyrimidine derivatives |
| title_short | Syntheses and anti-microbial evaluation of new quinoline scaffold derived pyrimidine derivatives |
| title_sort | syntheses and anti microbial evaluation of new quinoline scaffold derived pyrimidine derivatives |
| topic | Quinoline Chalcone Pyrimidine Antimicrobial activity Anti-fungal activity |
| url | http://www.sciencedirect.com/science/article/pii/S1878535211001614 |
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