Contribution of subcortical structures to cognition assessed with invasive electrophysiology in humans
Implantation of deep brain stimulation (DBS) electrodes via stereotactic neurosurgery has become a standard procedure for the treatment of Parkinson’s disease. More recently, the range of neuropsychiatric conditions and the possible target structures suitable for DBS have greatly increased...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2008-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.01.006.2008/full |
| _version_ | 1819142308469145600 |
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| author | Thomas F Münte Marcus Heldmann Marcus Heldmann Hermann Hinrichs Josep Marco-Pallares Ulrike M Krämer Volker Sturm Hans-Jochen Heinze |
| author_facet | Thomas F Münte Marcus Heldmann Marcus Heldmann Hermann Hinrichs Josep Marco-Pallares Ulrike M Krämer Volker Sturm Hans-Jochen Heinze |
| author_sort | Thomas F Münte |
| collection | DOAJ |
| description | Implantation of deep brain stimulation (DBS) electrodes via stereotactic neurosurgery has become a standard procedure for the treatment of Parkinson’s disease. More recently, the range of neuropsychiatric conditions and the possible target structures suitable for DBS have greatly increased. The former include obsessive compulsive disease, depression, obesity, tremor, dystonia, Tourette’s syndrome and cluster-headache. In this article we argue that several of the target structures for DBS (nucleus accumbens, posterior inferior hypothalamus, nucleus subthalamicus, nuclei in the thalamus, globus pallidus internus, nucleus pedunculopontinus) are located at strategic positions with brain circuits related to motivational behaviors, learning, and motor regulation. Recording from DBS electrodes either during the operation or post-operatively from externalized leads while the patient is performing cognitive tasks tapping the functions of the respective circuits provides a new window on the brain mechanisms underlying these functions. This is exemplified by a study of a patient suffering from obsessive-compulsive disease from whom we recorded in a flanker task designed to tap action monitoring processes while he received a DBS electrode in the right nucleus accumbens. Clear error-related modulations were obtained from the target structure, demonstrating a role of the nucleus accumbens in action monitoring. Based on recent conceptualizations of several different functional loops and on neuroimaging results we suggest further lines of research using this new window on brain functions. |
| first_indexed | 2024-12-22T12:08:17Z |
| format | Article |
| id | doaj.art-1fd9cc07dd094c2b9fd0ce3321abee11 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-22T12:08:17Z |
| publishDate | 2008-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-1fd9cc07dd094c2b9fd0ce3321abee112022-12-21T18:26:23ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2008-07-01210.3389/neuro.01.006.2008262Contribution of subcortical structures to cognition assessed with invasive electrophysiology in humansThomas F Münte0Marcus Heldmann1Marcus Heldmann2Hermann Hinrichs3Josep Marco-Pallares4Ulrike M Krämer5Volker Sturm6Hans-Jochen Heinze7Neuropsychology, Neuropsychology, Neuropsychology, University of MagdeburgNeurology II , Neurology II , Neurology II , University of MagdeburgNeuropsychology, Neuropsychology, Neuropsychology, University of MagdeburgNeurology II , Neurology II , Neurology II , University of MagdeburgNeuropsychology, Neuropsychology, Neuropsychology, University of MagdeburgNeuropsychology, Neuropsychology, Neuropsychology, University of MagdeburgStereotactic Neurosurgery, Stereotactic Neurosurgery, Stereotactic Neurosurgery, University of CologneNeurology II , Neurology II , Neurology II , University of MagdeburgImplantation of deep brain stimulation (DBS) electrodes via stereotactic neurosurgery has become a standard procedure for the treatment of Parkinson’s disease. More recently, the range of neuropsychiatric conditions and the possible target structures suitable for DBS have greatly increased. The former include obsessive compulsive disease, depression, obesity, tremor, dystonia, Tourette’s syndrome and cluster-headache. In this article we argue that several of the target structures for DBS (nucleus accumbens, posterior inferior hypothalamus, nucleus subthalamicus, nuclei in the thalamus, globus pallidus internus, nucleus pedunculopontinus) are located at strategic positions with brain circuits related to motivational behaviors, learning, and motor regulation. Recording from DBS electrodes either during the operation or post-operatively from externalized leads while the patient is performing cognitive tasks tapping the functions of the respective circuits provides a new window on the brain mechanisms underlying these functions. This is exemplified by a study of a patient suffering from obsessive-compulsive disease from whom we recorded in a flanker task designed to tap action monitoring processes while he received a DBS electrode in the right nucleus accumbens. Clear error-related modulations were obtained from the target structure, demonstrating a role of the nucleus accumbens in action monitoring. Based on recent conceptualizations of several different functional loops and on neuroimaging results we suggest further lines of research using this new window on brain functions.http://journal.frontiersin.org/Journal/10.3389/neuro.01.006.2008/fullAction MonitoringDeep Brain StimulationElectrophysiologyMemoryMotivationNucleus Accumbens |
| spellingShingle | Thomas F Münte Marcus Heldmann Marcus Heldmann Hermann Hinrichs Josep Marco-Pallares Ulrike M Krämer Volker Sturm Hans-Jochen Heinze Contribution of subcortical structures to cognition assessed with invasive electrophysiology in humans Frontiers in Neuroscience Action Monitoring Deep Brain Stimulation Electrophysiology Memory Motivation Nucleus Accumbens |
| title | Contribution of subcortical structures to cognition assessed with invasive electrophysiology in humans |
| title_full | Contribution of subcortical structures to cognition assessed with invasive electrophysiology in humans |
| title_fullStr | Contribution of subcortical structures to cognition assessed with invasive electrophysiology in humans |
| title_full_unstemmed | Contribution of subcortical structures to cognition assessed with invasive electrophysiology in humans |
| title_short | Contribution of subcortical structures to cognition assessed with invasive electrophysiology in humans |
| title_sort | contribution of subcortical structures to cognition assessed with invasive electrophysiology in humans |
| topic | Action Monitoring Deep Brain Stimulation Electrophysiology Memory Motivation Nucleus Accumbens |
| url | http://journal.frontiersin.org/Journal/10.3389/neuro.01.006.2008/full |
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