Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner
The mechanisms underlying striatal cholinergic interneurons (ChINs) synchronization and its interaction with dopamine release are unclear. Here, the authors showed that polysynaptic inhibition between ChINs shapes their network activity and is mediated by dopaminergic input.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18882-y |
| _version_ | 1818423292777725952 |
|---|---|
| author | Matthijs C. Dorst Anna Tokarska Ming Zhou Kwang Lee Stefanos Stagkourakis Christian Broberger Sotiris Masmanidis Gilad Silberberg |
| author_facet | Matthijs C. Dorst Anna Tokarska Ming Zhou Kwang Lee Stefanos Stagkourakis Christian Broberger Sotiris Masmanidis Gilad Silberberg |
| author_sort | Matthijs C. Dorst |
| collection | DOAJ |
| description | The mechanisms underlying striatal cholinergic interneurons (ChINs) synchronization and its interaction with dopamine release are unclear. Here, the authors showed that polysynaptic inhibition between ChINs shapes their network activity and is mediated by dopaminergic input. |
| first_indexed | 2024-12-14T13:39:50Z |
| format | Article |
| id | doaj.art-1fdabad6eef745dface4757819df6459 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:39:50Z |
| publishDate | 2020-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1fdabad6eef745dface4757819df64592022-12-21T22:59:29ZengNature PortfolioNature Communications2041-17232020-10-0111111710.1038/s41467-020-18882-yPolysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent mannerMatthijs C. Dorst0Anna Tokarska1Ming Zhou2Kwang Lee3Stefanos Stagkourakis4Christian Broberger5Sotiris Masmanidis6Gilad Silberberg7Department of Neuroscience, Karolinska InstitutetDepartment of Neuroscience, Karolinska InstitutetDepartment of Neuroscience, Karolinska InstitutetDepartment of Neurobiology, University of California, Los AngelesDepartment of Neuroscience, Karolinska InstitutetDepartment of Neuroscience, Karolinska InstitutetDepartment of Neurobiology, University of California, Los AngelesDepartment of Neuroscience, Karolinska InstitutetThe mechanisms underlying striatal cholinergic interneurons (ChINs) synchronization and its interaction with dopamine release are unclear. Here, the authors showed that polysynaptic inhibition between ChINs shapes their network activity and is mediated by dopaminergic input.https://doi.org/10.1038/s41467-020-18882-y |
| spellingShingle | Matthijs C. Dorst Anna Tokarska Ming Zhou Kwang Lee Stefanos Stagkourakis Christian Broberger Sotiris Masmanidis Gilad Silberberg Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner Nature Communications |
| title | Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner |
| title_full | Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner |
| title_fullStr | Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner |
| title_full_unstemmed | Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner |
| title_short | Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner |
| title_sort | polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine dependent manner |
| url | https://doi.org/10.1038/s41467-020-18882-y |
| work_keys_str_mv | AT matthijscdorst polysynapticinhibitionbetweenstriatalcholinergicinterneuronsshapestheirnetworkactivitypatternsinadopaminedependentmanner AT annatokarska polysynapticinhibitionbetweenstriatalcholinergicinterneuronsshapestheirnetworkactivitypatternsinadopaminedependentmanner AT mingzhou polysynapticinhibitionbetweenstriatalcholinergicinterneuronsshapestheirnetworkactivitypatternsinadopaminedependentmanner AT kwanglee polysynapticinhibitionbetweenstriatalcholinergicinterneuronsshapestheirnetworkactivitypatternsinadopaminedependentmanner AT stefanosstagkourakis polysynapticinhibitionbetweenstriatalcholinergicinterneuronsshapestheirnetworkactivitypatternsinadopaminedependentmanner AT christianbroberger polysynapticinhibitionbetweenstriatalcholinergicinterneuronsshapestheirnetworkactivitypatternsinadopaminedependentmanner AT sotirismasmanidis polysynapticinhibitionbetweenstriatalcholinergicinterneuronsshapestheirnetworkactivitypatternsinadopaminedependentmanner AT giladsilberberg polysynapticinhibitionbetweenstriatalcholinergicinterneuronsshapestheirnetworkactivitypatternsinadopaminedependentmanner |