Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology
Daba Abdissa Department of Biomedical Sciences, College of Medical Science, Institute of Health Science, Jimma University, Jimma, EthiopiaCorrespondence: Daba AbdissaJimma University, Jimma, EthiopiaEmail dhaabaa4@gmail.comAbstract: The global burden of chronic kidney disease (CKD) has risen, and ch...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-12-01
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| Series: | International Journal of Nephrology and Renovascular Disease |
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| Online Access: | https://www.dovepress.com/purposeful-review-to-identify-risk-factors-epidemiology-clinical-featu-peer-reviewed-article-IJNRD |
| _version_ | 1818876616285093888 |
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| author | Abdissa D |
| author_facet | Abdissa D |
| author_sort | Abdissa D |
| collection | DOAJ |
| description | Daba Abdissa Department of Biomedical Sciences, College of Medical Science, Institute of Health Science, Jimma University, Jimma, EthiopiaCorrespondence: Daba AbdissaJimma University, Jimma, EthiopiaEmail dhaabaa4@gmail.comAbstract: The global burden of chronic kidney disease (CKD) has risen, and chronic kidney disease of unknown etiology (CKDu) contributes considerably to the national burden of CKD. It is characterized by irreversible, slowly advancing disease, and symptoms often appear in the late stages of the disease. It is a serious, novel cause of kidney failure and leads to premature deaths. Many hypotheses have emerged; however, the etiology of CKDu continues to be elusive and debatable and it is claimed that the etiology is multifactorial, encompassing environmental, genetic, occupational, and social factors. The dominant histopathological feature is chronic tubulointerstitial nephritis. It predominantly affects individuals with low socio-economic status, of working age, largely without chronic comorbidities, who perform strenuous labor in extreme conditions in various tropical areas of the world. It is often fatal due to fast progression and limited access to dialysis or transplant options in the involved geographic areas. Early recognition and appropriate interventions at the earliest possible stage are imperative for decreasing its associated morbidity and mortality. In this review, I tried to summarize available evidence on the risk factors, epidemiology, clinical features, treatment, and prevention of CKDu. The literature search for this review was conducted comprehensively by using different electronic databases and by using appropriate search terms.Keywords: chronic kidney disease of unknown etiology, review, risk factors |
| first_indexed | 2024-12-19T13:45:13Z |
| format | Article |
| id | doaj.art-1fdb9aac23974126b102b043d4025adc |
| institution | Directory Open Access Journal |
| issn | 1178-7058 |
| language | English |
| last_indexed | 2024-12-19T13:45:13Z |
| publishDate | 2020-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nephrology and Renovascular Disease |
| spelling | doaj.art-1fdb9aac23974126b102b043d4025adc2022-12-21T20:18:52ZengDove Medical PressInternational Journal of Nephrology and Renovascular Disease1178-70582020-12-01Volume 1336737760250Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown EtiologyAbdissa DDaba Abdissa Department of Biomedical Sciences, College of Medical Science, Institute of Health Science, Jimma University, Jimma, EthiopiaCorrespondence: Daba AbdissaJimma University, Jimma, EthiopiaEmail dhaabaa4@gmail.comAbstract: The global burden of chronic kidney disease (CKD) has risen, and chronic kidney disease of unknown etiology (CKDu) contributes considerably to the national burden of CKD. It is characterized by irreversible, slowly advancing disease, and symptoms often appear in the late stages of the disease. It is a serious, novel cause of kidney failure and leads to premature deaths. Many hypotheses have emerged; however, the etiology of CKDu continues to be elusive and debatable and it is claimed that the etiology is multifactorial, encompassing environmental, genetic, occupational, and social factors. The dominant histopathological feature is chronic tubulointerstitial nephritis. It predominantly affects individuals with low socio-economic status, of working age, largely without chronic comorbidities, who perform strenuous labor in extreme conditions in various tropical areas of the world. It is often fatal due to fast progression and limited access to dialysis or transplant options in the involved geographic areas. Early recognition and appropriate interventions at the earliest possible stage are imperative for decreasing its associated morbidity and mortality. In this review, I tried to summarize available evidence on the risk factors, epidemiology, clinical features, treatment, and prevention of CKDu. The literature search for this review was conducted comprehensively by using different electronic databases and by using appropriate search terms.Keywords: chronic kidney disease of unknown etiology, review, risk factorshttps://www.dovepress.com/purposeful-review-to-identify-risk-factors-epidemiology-clinical-featu-peer-reviewed-article-IJNRDchronic kidney disease of unknown etiologyreviewrisk factors |
| spellingShingle | Abdissa D Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology International Journal of Nephrology and Renovascular Disease chronic kidney disease of unknown etiology review risk factors |
| title | Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology |
| title_full | Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology |
| title_fullStr | Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology |
| title_full_unstemmed | Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology |
| title_short | Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology |
| title_sort | purposeful review to identify risk factors epidemiology clinical features treatment and prevention of chronic kidney disease of unknown etiology |
| topic | chronic kidney disease of unknown etiology review risk factors |
| url | https://www.dovepress.com/purposeful-review-to-identify-risk-factors-epidemiology-clinical-featu-peer-reviewed-article-IJNRD |
| work_keys_str_mv | AT abdissad purposefulreviewtoidentifyriskfactorsepidemiologyclinicalfeaturestreatmentandpreventionofchronickidneydiseaseofunknownetiology |