Alternative polyadenylation of mRNA and its role in cancer
Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3′ end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from the existence of multiple polyadenylation signals (PAS) within the same transcript, and results in the differential inclu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-01-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304219300984 |
| _version_ | 1797705699032039424 |
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| author | Fuwen Yuan William Hankey Eric J. Wagner Wei Li Qianben Wang |
| author_facet | Fuwen Yuan William Hankey Eric J. Wagner Wei Li Qianben Wang |
| author_sort | Fuwen Yuan |
| collection | DOAJ |
| description | Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3′ end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from the existence of multiple polyadenylation signals (PAS) within the same transcript, and results in the differential inclusion of sequence information at the 3′ end. While APA can occur between two PASs allowing for generation of transcripts with distinct coding potential from a single gene, most APA occurs within the untranslated region (3′UTR) and changes the length and content of these non-coding sequences. APA within the 3′UTR can have tremendous impact on its regulatory potential of the mRNA through a variety of mechanisms, and indeed this layer of gene expression regulation has profound impact on processes vital to cell growth and development. Recent studies have particularly highlighted the importance of APA dysregulation in cancer onset and progression. Here, we review the current knowledge of APA and its impacts on mRNA stability, translation, localization and protein localization. We also discuss the implications of APA dysregulation in cancer research and therapy. |
| first_indexed | 2024-03-12T05:40:15Z |
| format | Article |
| id | doaj.art-1fdbe9364a794efa863ce2aa3af8042c |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T05:40:15Z |
| publishDate | 2021-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-1fdbe9364a794efa863ce2aa3af8042c2023-09-03T06:06:22ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422021-01-01816172Alternative polyadenylation of mRNA and its role in cancerFuwen Yuan0William Hankey1Eric J. Wagner2Wei Li3Qianben Wang4Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USADepartment of Pathology, Duke University School of Medicine, Durham, NC, 27710, USADepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USADepartment of Biological Chemistry, University of California, Irvine, CA, 92697, USADepartment of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA; Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University School of Medicine, Durham, NC, 27710, USA; Corresponding author. Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA. Fax: +1 9193857554.Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3′ end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from the existence of multiple polyadenylation signals (PAS) within the same transcript, and results in the differential inclusion of sequence information at the 3′ end. While APA can occur between two PASs allowing for generation of transcripts with distinct coding potential from a single gene, most APA occurs within the untranslated region (3′UTR) and changes the length and content of these non-coding sequences. APA within the 3′UTR can have tremendous impact on its regulatory potential of the mRNA through a variety of mechanisms, and indeed this layer of gene expression regulation has profound impact on processes vital to cell growth and development. Recent studies have particularly highlighted the importance of APA dysregulation in cancer onset and progression. Here, we review the current knowledge of APA and its impacts on mRNA stability, translation, localization and protein localization. We also discuss the implications of APA dysregulation in cancer research and therapy.http://www.sciencedirect.com/science/article/pii/S23523042193009843′ untranslated regionAlternative polyadenylationCancerGene regulationPolyadenylation signals |
| spellingShingle | Fuwen Yuan William Hankey Eric J. Wagner Wei Li Qianben Wang Alternative polyadenylation of mRNA and its role in cancer Genes and Diseases 3′ untranslated region Alternative polyadenylation Cancer Gene regulation Polyadenylation signals |
| title | Alternative polyadenylation of mRNA and its role in cancer |
| title_full | Alternative polyadenylation of mRNA and its role in cancer |
| title_fullStr | Alternative polyadenylation of mRNA and its role in cancer |
| title_full_unstemmed | Alternative polyadenylation of mRNA and its role in cancer |
| title_short | Alternative polyadenylation of mRNA and its role in cancer |
| title_sort | alternative polyadenylation of mrna and its role in cancer |
| topic | 3′ untranslated region Alternative polyadenylation Cancer Gene regulation Polyadenylation signals |
| url | http://www.sciencedirect.com/science/article/pii/S2352304219300984 |
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