Role of SARS-CoV-2 and ACE2 variations in COVID-19
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is one of the worst medical emergencies that has hit the world in almost a century. The virus has now spread to a large number of countries/territories and has caused over three million d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Biomedical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417021000366 |
| _version_ | 1811212557496614912 |
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| author | Priya Antony Ranjit Vijayan |
| author_facet | Priya Antony Ranjit Vijayan |
| author_sort | Priya Antony |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is one of the worst medical emergencies that has hit the world in almost a century. The virus has now spread to a large number of countries/territories and has caused over three million deaths. Evidently, the virus has been mutating and adapting during this period. Significant effort has been spent on identifying these variations and their impact on transmission, virulence and pathogenicity of SARS-CoV-2. Binding of the SARS-CoV-2 spike protein to the angiotensin converting enzyme 2 (ACE2) promotes cellular entry. Therefore, human ACE2 variations could also influence susceptibility or resistance to the virus. A deeper understanding of the evolution and genetic variations in SARS-CoV-2 as well as ACE2 could contribute to the development of effective treatment and preventive measures. Here, we review the literature on SARS-CoV-2 and ACE2 variations and their role in COVID-19. |
| first_indexed | 2024-04-12T05:31:03Z |
| format | Article |
| id | doaj.art-1fdf41e27d5e4e84a34e617669f4be90 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-04-12T05:31:03Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-1fdf41e27d5e4e84a34e617669f4be902022-12-22T03:46:04ZengElsevierBiomedical Journal2319-41702021-06-01443235244Role of SARS-CoV-2 and ACE2 variations in COVID-19Priya Antony0Ranjit Vijayan1Department of Biology, College of Science, United Arab Emirates University, PO Box 15551, Al Ain, Abu Dhabi, United Arab EmiratesCorresponding author.; Department of Biology, College of Science, United Arab Emirates University, PO Box 15551, Al Ain, Abu Dhabi, United Arab EmiratesCoronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is one of the worst medical emergencies that has hit the world in almost a century. The virus has now spread to a large number of countries/territories and has caused over three million deaths. Evidently, the virus has been mutating and adapting during this period. Significant effort has been spent on identifying these variations and their impact on transmission, virulence and pathogenicity of SARS-CoV-2. Binding of the SARS-CoV-2 spike protein to the angiotensin converting enzyme 2 (ACE2) promotes cellular entry. Therefore, human ACE2 variations could also influence susceptibility or resistance to the virus. A deeper understanding of the evolution and genetic variations in SARS-CoV-2 as well as ACE2 could contribute to the development of effective treatment and preventive measures. Here, we review the literature on SARS-CoV-2 and ACE2 variations and their role in COVID-19.http://www.sciencedirect.com/science/article/pii/S2319417021000366SARS-CoV-2COVID-19ACE2Spike proteinVariations |
| spellingShingle | Priya Antony Ranjit Vijayan Role of SARS-CoV-2 and ACE2 variations in COVID-19 Biomedical Journal SARS-CoV-2 COVID-19 ACE2 Spike protein Variations |
| title | Role of SARS-CoV-2 and ACE2 variations in COVID-19 |
| title_full | Role of SARS-CoV-2 and ACE2 variations in COVID-19 |
| title_fullStr | Role of SARS-CoV-2 and ACE2 variations in COVID-19 |
| title_full_unstemmed | Role of SARS-CoV-2 and ACE2 variations in COVID-19 |
| title_short | Role of SARS-CoV-2 and ACE2 variations in COVID-19 |
| title_sort | role of sars cov 2 and ace2 variations in covid 19 |
| topic | SARS-CoV-2 COVID-19 ACE2 Spike protein Variations |
| url | http://www.sciencedirect.com/science/article/pii/S2319417021000366 |
| work_keys_str_mv | AT priyaantony roleofsarscov2andace2variationsincovid19 AT ranjitvijayan roleofsarscov2andace2variationsincovid19 |