Caspase-8 contributes to an immuno-hot microenvironment by promoting phagocytosis via an ecto-calreticulin-dependent mechanism

Caspase-8 contributes to an immuno-hot microenvironment by promoting phagocytosis via an ecto-calreticulin-dependent mechanism

Abstract Background Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades. M...

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Bibliographic Details
Main Authors: Zhihua Gong, Qingzhu Jia, Jinming Guo, Chongyi Li, Shouxia Xu, Zheng Jin, Han Chu, Yisong Y. Wan, Bo Zhu, Yi Zhou
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Experimental Hematology & Oncology
Subjects:
Caspase-8
Calreticulin
Antigen presentation
Dendritic cells
Immunotherapy
Tumor microenvironment
Online Access:https://doi.org/10.1186/s40164-022-00371-1

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