Effects of SARS-CoV-2 infection on hypothyroidism and subclinical hypothyroidism: a meta-analysis
BackgroundIn recent years, the outbreak of COVID-19 caused by SARS-CoV-2 has been witnessed globally. However, the impact of SARS-CoV-2 infection on thyroid dysfunction and subclinical thyroid dysfunction remains unclear. Therefore, this meta-analysis aimed to assess the effects of SARS-CoV-2 infect...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1291774/full |
| _version_ | 1827596170131668992 |
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| author | Jiaqi Wei Fenghua Zhang |
| author_facet | Jiaqi Wei Fenghua Zhang |
| author_sort | Jiaqi Wei |
| collection | DOAJ |
| description | BackgroundIn recent years, the outbreak of COVID-19 caused by SARS-CoV-2 has been witnessed globally. However, the impact of SARS-CoV-2 infection on thyroid dysfunction and subclinical thyroid dysfunction remains unclear. Therefore, this meta-analysis aimed to assess the effects of SARS-CoV-2 infection on thyroid dysfunction and its relationship with the severity of COVID-19.MethodsWe systematically searched databases including PubMed, Willey Library, Embase, Web of Science, CNKI, Wanfang, and VIP. We focused on randomized controlled trials, case-control studies, and cohort studies published between December 2019 and August 2023, examining the association between SARS-CoV-2 infection and hypothyroidism, with a specific emphasis on the severity of the infection. The quality of the research was assessed using the Newcastle-Ottawa Scale (NOS), while statistical analysis was conducted using the meta and metafor packages in R 4.2.1 software.ResultsFor the meta-analysis, a total of eight articles were identified based on strict inclusion and exclusion criteria. For the association between SARS-CoV-2 infection and hypothyroidism, three studies (266 samples) comparing TSH levels of COVID-19 and control groups showed no difference in TSH levels [SMD=-0.04,95%CI(-1.22,1.15),P=0.95]. Additionally, two studies examining TT3 (a sample of 176 cases) and two studies examining TT4 (a sample of 176 cases) also showed no difference in TT3 and TT4 between the COVID-19 group and the control group, respectively. However, when evaluating the severity of COVID-19, six studies (565 samples) showed that TSH in the severe group was significantly lower than in the mild group [SMD = -0.55, 95% CI (-0.96, -0.14)], while FT3 was also lower in the severe group [SMD = -0.96, 95% CI (-1.24, -0.67)]. No noticeable differences were observed between the severe and mild groups in their TT3, FT4, and TT4 levels.ConclusionSARS-CoV-2 infection may have detrimental effects on thyroid function in individuals with severe symptoms. More research is needed to confirm and explore this relationship.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023486042. |
| first_indexed | 2024-03-09T03:05:43Z |
| format | Article |
| id | doaj.art-1fdfe3144a684add96311ee82c75db94 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-09T03:05:43Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1fdfe3144a684add96311ee82c75db942023-12-04T06:58:59ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-12-011410.3389/fendo.2023.12917741291774Effects of SARS-CoV-2 infection on hypothyroidism and subclinical hypothyroidism: a meta-analysisJiaqi Wei0Fenghua Zhang1College of Medical Technology, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaDepartment of Laboratory Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaBackgroundIn recent years, the outbreak of COVID-19 caused by SARS-CoV-2 has been witnessed globally. However, the impact of SARS-CoV-2 infection on thyroid dysfunction and subclinical thyroid dysfunction remains unclear. Therefore, this meta-analysis aimed to assess the effects of SARS-CoV-2 infection on thyroid dysfunction and its relationship with the severity of COVID-19.MethodsWe systematically searched databases including PubMed, Willey Library, Embase, Web of Science, CNKI, Wanfang, and VIP. We focused on randomized controlled trials, case-control studies, and cohort studies published between December 2019 and August 2023, examining the association between SARS-CoV-2 infection and hypothyroidism, with a specific emphasis on the severity of the infection. The quality of the research was assessed using the Newcastle-Ottawa Scale (NOS), while statistical analysis was conducted using the meta and metafor packages in R 4.2.1 software.ResultsFor the meta-analysis, a total of eight articles were identified based on strict inclusion and exclusion criteria. For the association between SARS-CoV-2 infection and hypothyroidism, three studies (266 samples) comparing TSH levels of COVID-19 and control groups showed no difference in TSH levels [SMD=-0.04,95%CI(-1.22,1.15),P=0.95]. Additionally, two studies examining TT3 (a sample of 176 cases) and two studies examining TT4 (a sample of 176 cases) also showed no difference in TT3 and TT4 between the COVID-19 group and the control group, respectively. However, when evaluating the severity of COVID-19, six studies (565 samples) showed that TSH in the severe group was significantly lower than in the mild group [SMD = -0.55, 95% CI (-0.96, -0.14)], while FT3 was also lower in the severe group [SMD = -0.96, 95% CI (-1.24, -0.67)]. No noticeable differences were observed between the severe and mild groups in their TT3, FT4, and TT4 levels.ConclusionSARS-CoV-2 infection may have detrimental effects on thyroid function in individuals with severe symptoms. More research is needed to confirm and explore this relationship.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023486042.https://www.frontiersin.org/articles/10.3389/fendo.2023.1291774/fullSARS-CoV-2COVID-19hypothyroidismsubclinical hypothyroidismmeta-analysis |
| spellingShingle | Jiaqi Wei Fenghua Zhang Effects of SARS-CoV-2 infection on hypothyroidism and subclinical hypothyroidism: a meta-analysis Frontiers in Endocrinology SARS-CoV-2 COVID-19 hypothyroidism subclinical hypothyroidism meta-analysis |
| title | Effects of SARS-CoV-2 infection on hypothyroidism and subclinical hypothyroidism: a meta-analysis |
| title_full | Effects of SARS-CoV-2 infection on hypothyroidism and subclinical hypothyroidism: a meta-analysis |
| title_fullStr | Effects of SARS-CoV-2 infection on hypothyroidism and subclinical hypothyroidism: a meta-analysis |
| title_full_unstemmed | Effects of SARS-CoV-2 infection on hypothyroidism and subclinical hypothyroidism: a meta-analysis |
| title_short | Effects of SARS-CoV-2 infection on hypothyroidism and subclinical hypothyroidism: a meta-analysis |
| title_sort | effects of sars cov 2 infection on hypothyroidism and subclinical hypothyroidism a meta analysis |
| topic | SARS-CoV-2 COVID-19 hypothyroidism subclinical hypothyroidism meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1291774/full |
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