Effect and Mechanism of PINK1/Parkin-Mediated Mitochondrial Autophagy in Rat Lung Injury Induced by Nano Lanthanum Oxide
Nano lanthanum oxide particles (La<sub>2</sub>O<sub>3</sub> NPs) are important nanoparticle materials which are widely used in photoelectric production, but their potential health hazards to the respiratory system are not clear. The purpose of this study was to explore the po...
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MDPI AG
2022-07-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/15/2594 |
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| author | Chunyu Chen Chenxi Zhou Wenli Zhang Haiping Liu Mengfei Wang Feng Li Qingzhao Li Yanhua Cao |
| author_facet | Chunyu Chen Chenxi Zhou Wenli Zhang Haiping Liu Mengfei Wang Feng Li Qingzhao Li Yanhua Cao |
| author_sort | Chunyu Chen |
| collection | DOAJ |
| description | Nano lanthanum oxide particles (La<sub>2</sub>O<sub>3</sub> NPs) are important nanoparticle materials which are widely used in photoelectric production, but their potential health hazards to the respiratory system are not clear. The purpose of this study was to explore the possible mechanism of lung injury induced by La<sub>2</sub>O<sub>3</sub> NPs. In this study, 40 SPF male SD rats were randomly divided into low-, medium-, and high-dose groups and control groups, with 10 animals in each group. Rats were poisoned by tracheal injection. The low-, medium-, and high-dose groups were given La<sub>2</sub>O<sub>3</sub> NPs suspension of 25, 50, and 100 mg/kg, respectively, and the control group was given an equal volume of high-temperature sterilized ultrapure water. The rats in each group were exposed once a week for 12 consecutive times. The gene transcription and protein expression levels of PINK1 and parkin in rat lung tissue were mainly detected. Compared with the control group, the gene transcription and protein expression levels of PINK1 and Parkin in the exposed group were significantly higher (<i>p</i> < 0.05). La<sub>2</sub>O<sub>3</sub> NPs may activate PINK1/parkin-induced mitochondrial autophagy. |
| first_indexed | 2024-03-09T12:19:34Z |
| format | Article |
| id | doaj.art-1fe117f27d9a48578872c9265e227cc8 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T12:19:34Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-1fe117f27d9a48578872c9265e227cc82023-11-30T22:42:28ZengMDPI AGNanomaterials2079-49912022-07-011215259410.3390/nano12152594Effect and Mechanism of PINK1/Parkin-Mediated Mitochondrial Autophagy in Rat Lung Injury Induced by Nano Lanthanum OxideChunyu Chen0Chenxi Zhou1Wenli Zhang2Haiping Liu3Mengfei Wang4Feng Li5Qingzhao Li6Yanhua Cao7School of Public Health, North China University of Science and Technology, Tangshan 063200, ChinaLin Yi Center for Disease Control and Prevention, Linyi 276100, ChinaComprehensive Testing and Analyzing Center, North China University of Science and Technology, Tangshan 063200, ChinaSchool of Public Health, North China University of Science and Technology, Tangshan 063200, ChinaSchool of Public Health, North China University of Science and Technology, Tangshan 063200, ChinaSchool of Public Health, North China University of Science and Technology, Tangshan 063200, ChinaSchool of Public Health, North China University of Science and Technology, Tangshan 063200, ChinaSchool of Public Health, North China University of Science and Technology, Tangshan 063200, ChinaNano lanthanum oxide particles (La<sub>2</sub>O<sub>3</sub> NPs) are important nanoparticle materials which are widely used in photoelectric production, but their potential health hazards to the respiratory system are not clear. The purpose of this study was to explore the possible mechanism of lung injury induced by La<sub>2</sub>O<sub>3</sub> NPs. In this study, 40 SPF male SD rats were randomly divided into low-, medium-, and high-dose groups and control groups, with 10 animals in each group. Rats were poisoned by tracheal injection. The low-, medium-, and high-dose groups were given La<sub>2</sub>O<sub>3</sub> NPs suspension of 25, 50, and 100 mg/kg, respectively, and the control group was given an equal volume of high-temperature sterilized ultrapure water. The rats in each group were exposed once a week for 12 consecutive times. The gene transcription and protein expression levels of PINK1 and parkin in rat lung tissue were mainly detected. Compared with the control group, the gene transcription and protein expression levels of PINK1 and Parkin in the exposed group were significantly higher (<i>p</i> < 0.05). La<sub>2</sub>O<sub>3</sub> NPs may activate PINK1/parkin-induced mitochondrial autophagy.https://www.mdpi.com/2079-4991/12/15/2594nanometer lanthanum oxidepulmonarymitochondrial autophagy injuryPINK1/parkin |
| spellingShingle | Chunyu Chen Chenxi Zhou Wenli Zhang Haiping Liu Mengfei Wang Feng Li Qingzhao Li Yanhua Cao Effect and Mechanism of PINK1/Parkin-Mediated Mitochondrial Autophagy in Rat Lung Injury Induced by Nano Lanthanum Oxide Nanomaterials nanometer lanthanum oxide pulmonary mitochondrial autophagy injury PINK1/parkin |
| title | Effect and Mechanism of PINK1/Parkin-Mediated Mitochondrial Autophagy in Rat Lung Injury Induced by Nano Lanthanum Oxide |
| title_full | Effect and Mechanism of PINK1/Parkin-Mediated Mitochondrial Autophagy in Rat Lung Injury Induced by Nano Lanthanum Oxide |
| title_fullStr | Effect and Mechanism of PINK1/Parkin-Mediated Mitochondrial Autophagy in Rat Lung Injury Induced by Nano Lanthanum Oxide |
| title_full_unstemmed | Effect and Mechanism of PINK1/Parkin-Mediated Mitochondrial Autophagy in Rat Lung Injury Induced by Nano Lanthanum Oxide |
| title_short | Effect and Mechanism of PINK1/Parkin-Mediated Mitochondrial Autophagy in Rat Lung Injury Induced by Nano Lanthanum Oxide |
| title_sort | effect and mechanism of pink1 parkin mediated mitochondrial autophagy in rat lung injury induced by nano lanthanum oxide |
| topic | nanometer lanthanum oxide pulmonary mitochondrial autophagy injury PINK1/parkin |
| url | https://www.mdpi.com/2079-4991/12/15/2594 |
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