BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study
Background: Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated. Methods: We conducted individual-level Mendelian randomization (MR) analyses targeting...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Japan Epidemiological Association
2024-02-01
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| Series: | Journal of Epidemiology |
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| Online Access: | https://www.jstage.jst.go.jp/article/jea/34/2/34_JE20220154/_pdf |
| _version_ | 1827355998545772544 |
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| author | Mako Nagayoshi Asahi Hishida Tomonori Shimizu Yasufumi Kato Yoko Kubo Rieko Okada Takashi Tamura Jun Otonari Hiroaki Ikezaki Megumi Hara Yuichiro Nishida Isao Oze Yuriko N. Koyanagi Yohko Nakamura Miho Kusakabe Rie Ibusuki Keiichi Shibuya Sadao Suzuki Takeshi Nishiyama Teruhide Koyama Etsuko Ozaki Kiyonori Kuriki Naoyuki Takashima Yasuyuki Nakamura Sakurako Katsuura-Kamano Kokichi Arisawa Masahiro Nakatochi Yukihide Momozawa Kenji Takeuchi Kenji Wakai |
| author_facet | Mako Nagayoshi Asahi Hishida Tomonori Shimizu Yasufumi Kato Yoko Kubo Rieko Okada Takashi Tamura Jun Otonari Hiroaki Ikezaki Megumi Hara Yuichiro Nishida Isao Oze Yuriko N. Koyanagi Yohko Nakamura Miho Kusakabe Rie Ibusuki Keiichi Shibuya Sadao Suzuki Takeshi Nishiyama Teruhide Koyama Etsuko Ozaki Kiyonori Kuriki Naoyuki Takashima Yasuyuki Nakamura Sakurako Katsuura-Kamano Kokichi Arisawa Masahiro Nakatochi Yukihide Momozawa Kenji Takeuchi Kenji Wakai |
| author_sort | Mako Nagayoshi |
| collection | DOAJ |
| description | Background: Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated. Methods: We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index (BMI)-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses using the two-stage least squares estimator method. The β-coefficients and standard errors for the per-allele association of each single-nucleotide polymorphism as well as all outcomes, or odds ratios with 95% confidence intervals were calculated in the two-sample MR analyses. Results: In individual-level MR analyses, the GRS of BMI was not significantly associated with any cardiometabolic traits. In two-sample MR analyses, higher BMI was associated with increased risks of higher blood pressure, triglycerides, and uric acid, as well as lower high-density-lipoprotein cholesterol and eGFR. The associations of BMI with type 2 diabetes in two-sample MR analyses were inconsistent using different methods, including the directions. Conclusion: The results of this study suggest that, even among the Japanese, an East Asian population with low levels of obesity, higher BMI could be causally associated with the development of a variety of cardiometabolic traits. Causality in those associations should be clarified in future studies with larger populations, especially those of BMI with type 2 diabetes. |
| first_indexed | 2024-03-08T04:51:20Z |
| format | Article |
| id | doaj.art-1fe2ba0af70e4df28d3ff077fe68ed7b |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-03-08T04:51:20Z |
| publishDate | 2024-02-01 |
| publisher | Japan Epidemiological Association |
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| series | Journal of Epidemiology |
| spelling | doaj.art-1fe2ba0af70e4df28d3ff077fe68ed7b2024-02-08T02:14:28ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922024-02-01342516210.2188/jea.JE20220154BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization StudyMako Nagayoshi0Asahi Hishida1Tomonori Shimizu2Yasufumi Kato3Yoko Kubo4Rieko Okada5Takashi Tamura6Jun Otonari7Hiroaki Ikezaki8Megumi Hara9Yuichiro Nishida10Isao Oze11Yuriko N. Koyanagi12Yohko Nakamura13Miho Kusakabe14Rie Ibusuki15Keiichi Shibuya16Sadao Suzuki17Takeshi Nishiyama18Teruhide Koyama19Etsuko Ozaki20Kiyonori Kuriki21Naoyuki Takashima22Yasuyuki Nakamura23Sakurako Katsuura-Kamano24Kokichi Arisawa25Masahiro Nakatochi26Yukihide Momozawa27Kenji Takeuchi28Kenji Wakai29Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanUndergraduate Course, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, JapanDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga, JapanDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga, JapanDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, JapanDivision of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, JapanCancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, JapanCancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, JapanDepartment of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanDepartment of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanDepartment of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, JapanLaboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, JapanDepartment of Public Health, Faculty of Medicine, Kindai University, Osaka, JapanDepartment of Public Health, Shiga University of Medical Science, Otsu, JapanDepartment of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, JapanDepartment of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, JapanPublic Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, JapanLaboratory for Genotyping Development, Center for Integrative Medical Sciences, Kanagawa, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanBackground: Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated. Methods: We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index (BMI)-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses using the two-stage least squares estimator method. The β-coefficients and standard errors for the per-allele association of each single-nucleotide polymorphism as well as all outcomes, or odds ratios with 95% confidence intervals were calculated in the two-sample MR analyses. Results: In individual-level MR analyses, the GRS of BMI was not significantly associated with any cardiometabolic traits. In two-sample MR analyses, higher BMI was associated with increased risks of higher blood pressure, triglycerides, and uric acid, as well as lower high-density-lipoprotein cholesterol and eGFR. The associations of BMI with type 2 diabetes in two-sample MR analyses were inconsistent using different methods, including the directions. Conclusion: The results of this study suggest that, even among the Japanese, an East Asian population with low levels of obesity, higher BMI could be causally associated with the development of a variety of cardiometabolic traits. Causality in those associations should be clarified in future studies with larger populations, especially those of BMI with type 2 diabetes.https://www.jstage.jst.go.jp/article/jea/34/2/34_JE20220154/_pdfbody mass indexdiabetes mellituscardiometabolic risk factorsmendelian randomization analysiseast asian people |
| spellingShingle | Mako Nagayoshi Asahi Hishida Tomonori Shimizu Yasufumi Kato Yoko Kubo Rieko Okada Takashi Tamura Jun Otonari Hiroaki Ikezaki Megumi Hara Yuichiro Nishida Isao Oze Yuriko N. Koyanagi Yohko Nakamura Miho Kusakabe Rie Ibusuki Keiichi Shibuya Sadao Suzuki Takeshi Nishiyama Teruhide Koyama Etsuko Ozaki Kiyonori Kuriki Naoyuki Takashima Yasuyuki Nakamura Sakurako Katsuura-Kamano Kokichi Arisawa Masahiro Nakatochi Yukihide Momozawa Kenji Takeuchi Kenji Wakai BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study Journal of Epidemiology body mass index diabetes mellitus cardiometabolic risk factors mendelian randomization analysis east asian people |
| title | BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study |
| title_full | BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study |
| title_fullStr | BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study |
| title_full_unstemmed | BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study |
| title_short | BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study |
| title_sort | bmi and cardiometabolic traits in japanese a mendelian randomization study |
| topic | body mass index diabetes mellitus cardiometabolic risk factors mendelian randomization analysis east asian people |
| url | https://www.jstage.jst.go.jp/article/jea/34/2/34_JE20220154/_pdf |
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