Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice

Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice

Abstract Transactive response DNA-binding protein 43 kDa (TDP-43) has been identified as the major component of ubiquitinated inclusions found in patients with sporadic amyotrophic lateral sclerosis (ALS). Increasing evidence suggests prion-like transmission of TDP-43 aggregates via neuroanatomic co...

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Bibliographic Details
Main Authors: Xuebing Ding, Zhi Xiang, Chi Qin, Yongkang Chen, Haiyan Tian, Lin Meng, Danhao Xia, Han Liu, Jia Song, Jun Fu, Mingming Ma, Xuejing Wang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis
Transactive response DNA-binding protein 43 kDa
Pyramidal tract
Preformed fibrils
Prion-like transmission
Online Access:https://doi.org/10.1186/s40478-020-01112-3

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