Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study
The brain undergoes many changes at pathological and functional levels in healthy aging. This study employed a longitudinal and multimodal imaging dataset from the OASIS-3 study (n = 300) and explored possible relationships between amyloid beta (Aβ) accumulation and functional brain organization ove...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811923002975 |
| _version_ | 1797812076131909632 |
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| author | Guodong Liu Chenye Shen Anqi Qiu |
| author_facet | Guodong Liu Chenye Shen Anqi Qiu |
| author_sort | Guodong Liu |
| collection | DOAJ |
| description | The brain undergoes many changes at pathological and functional levels in healthy aging. This study employed a longitudinal and multimodal imaging dataset from the OASIS-3 study (n = 300) and explored possible relationships between amyloid beta (Aβ) accumulation and functional brain organization over time in healthy aging. We used positron emission tomography (PET) with Pittsburgh compound-B (PIB) to quantify the Aβ accumulation in the brain and resting-state functional MRI (rs-fMRI) to measure functional connectivity (FC) among brain regions. Each participant had at least 2 to 3 follow-up visits. A linear mixed-effect model was used to examine longitudinal changes of Aβ accumulation and FC throughout the whole brain. We found that the limbic and frontoparietal networks had a greater annual Aβ accumulation and a slower decline in FC in aging. Additionally, the amount of the Aβ deposition in the amygdala network at baseline slowed down the decline in its FC in aging. Furthermore, the functional connectivity of the limbic, default mode network (DMN), and frontoparietal networks accelerated the Aβ propagation across their functionally highly connected regions. The functional connectivity of the somatomotor and visual networks accelerated the Aβ propagation across the brain regions in the limbic, frontoparietal, and DMN networks. These findings suggested that the slower decline in the functional connectivity of the functional hubs may compensate for their greater Aβ accumulation in aging. The Aβ propagation from one brain region to the other may depend on their functional connectivity strength. |
| first_indexed | 2024-03-13T07:33:12Z |
| format | Article |
| id | doaj.art-1fe36d164f5846fdbd8aa64ad2c1e5c6 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-03-13T07:33:12Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-1fe36d164f5846fdbd8aa64ad2c1e5c62023-06-04T04:23:10ZengElsevierNeuroImage1095-95722023-07-01275120146Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal studyGuodong Liu0Chenye Shen1Anqi Qiu2Department of Biomedical Engineering, National University of Singapore, SingaporeDepartment of Biomedical Engineering, National University of Singapore, SingaporeDepartment of Biomedical Engineering, National University of Singapore, Singapore; NUS (Suzhou) Research Institute, National University of Singapore, China; The N.1 Institute for Health, National University of Singapore, Singapore; Institute of Data Science, National University of Singapore, Singapore; Department of Health Technology and Informatics, the Hong Kong Polytechnic University; Department of Biomedical Engineering, the Johns Hopkins University, USA; Corresponding author at: Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Block E4 #04-08, Singapore 117583, Singapore.The brain undergoes many changes at pathological and functional levels in healthy aging. This study employed a longitudinal and multimodal imaging dataset from the OASIS-3 study (n = 300) and explored possible relationships between amyloid beta (Aβ) accumulation and functional brain organization over time in healthy aging. We used positron emission tomography (PET) with Pittsburgh compound-B (PIB) to quantify the Aβ accumulation in the brain and resting-state functional MRI (rs-fMRI) to measure functional connectivity (FC) among brain regions. Each participant had at least 2 to 3 follow-up visits. A linear mixed-effect model was used to examine longitudinal changes of Aβ accumulation and FC throughout the whole brain. We found that the limbic and frontoparietal networks had a greater annual Aβ accumulation and a slower decline in FC in aging. Additionally, the amount of the Aβ deposition in the amygdala network at baseline slowed down the decline in its FC in aging. Furthermore, the functional connectivity of the limbic, default mode network (DMN), and frontoparietal networks accelerated the Aβ propagation across their functionally highly connected regions. The functional connectivity of the somatomotor and visual networks accelerated the Aβ propagation across the brain regions in the limbic, frontoparietal, and DMN networks. These findings suggested that the slower decline in the functional connectivity of the functional hubs may compensate for their greater Aβ accumulation in aging. The Aβ propagation from one brain region to the other may depend on their functional connectivity strength.http://www.sciencedirect.com/science/article/pii/S1053811923002975Amyloid depositionFunctional brain organizationPositron emission tomographyResting-state FMRIBrain agingFunctional connectivity |
| spellingShingle | Guodong Liu Chenye Shen Anqi Qiu Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study NeuroImage Amyloid deposition Functional brain organization Positron emission tomography Resting-state FMRI Brain aging Functional connectivity |
| title | Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study |
| title_full | Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study |
| title_fullStr | Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study |
| title_full_unstemmed | Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study |
| title_short | Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study |
| title_sort | amyloid β accumulation in relation to functional connectivity in aging a longitudinal study |
| topic | Amyloid deposition Functional brain organization Positron emission tomography Resting-state FMRI Brain aging Functional connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S1053811923002975 |
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