Sodium Valproate-Induced Chromatin Remodeling
Valproic acid/sodium valproate (VPA), a drug originally prescribed as an anticonvulsant, has been widely reported to act on epigenetic marks by inducing histone acetylation, affecting the DNA and histone methylation status, and altering the expression of transcription factors, thus leading to modula...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.645518/full |
| _version_ | 1818655717661343744 |
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| author | Maria Luiza S. Mello |
| author_facet | Maria Luiza S. Mello |
| author_sort | Maria Luiza S. Mello |
| collection | DOAJ |
| description | Valproic acid/sodium valproate (VPA), a drug originally prescribed as an anticonvulsant, has been widely reported to act on epigenetic marks by inducing histone acetylation, affecting the DNA and histone methylation status, and altering the expression of transcription factors, thus leading to modulation of gene expression. All these epigenetic changes have been associated with chromatin remodeling effects. The present minireview briefly reports the main effects of VPA on chromatin and image analysis and Fourier transform infrared (FTIR) microspectroscopy in association with molecular biology methodological approaches to investigate the VPA-induced changes in chromatin structure and at the higher-order supraorganizational level. |
| first_indexed | 2024-12-17T03:14:08Z |
| format | Article |
| id | doaj.art-1fe40bda41f14ad6aabb34c859964767 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T03:14:08Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-1fe40bda41f14ad6aabb34c8599647672022-12-21T22:05:45ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-04-01910.3389/fcell.2021.645518645518Sodium Valproate-Induced Chromatin RemodelingMaria Luiza S. MelloValproic acid/sodium valproate (VPA), a drug originally prescribed as an anticonvulsant, has been widely reported to act on epigenetic marks by inducing histone acetylation, affecting the DNA and histone methylation status, and altering the expression of transcription factors, thus leading to modulation of gene expression. All these epigenetic changes have been associated with chromatin remodeling effects. The present minireview briefly reports the main effects of VPA on chromatin and image analysis and Fourier transform infrared (FTIR) microspectroscopy in association with molecular biology methodological approaches to investigate the VPA-induced changes in chromatin structure and at the higher-order supraorganizational level.https://www.frontiersin.org/articles/10.3389/fcell.2021.645518/fullchromatinsodium valproateepigeneticshistonesDNAimage analysis |
| spellingShingle | Maria Luiza S. Mello Sodium Valproate-Induced Chromatin Remodeling Frontiers in Cell and Developmental Biology chromatin sodium valproate epigenetics histones DNA image analysis |
| title | Sodium Valproate-Induced Chromatin Remodeling |
| title_full | Sodium Valproate-Induced Chromatin Remodeling |
| title_fullStr | Sodium Valproate-Induced Chromatin Remodeling |
| title_full_unstemmed | Sodium Valproate-Induced Chromatin Remodeling |
| title_short | Sodium Valproate-Induced Chromatin Remodeling |
| title_sort | sodium valproate induced chromatin remodeling |
| topic | chromatin sodium valproate epigenetics histones DNA image analysis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.645518/full |
| work_keys_str_mv | AT marialuizasmello sodiumvalproateinducedchromatinremodeling |