Associations of T-Cell Receptor Repertoire Diversity with L-Asparaginase Allergy in Childhood Acute Lymphoblastic Leukemia

Associations of T-Cell Receptor Repertoire Diversity with L-Asparaginase Allergy in Childhood Acute Lymphoblastic Leukemia

Asparaginase is a critical component of therapy for childhood acute lymphoblastic leukemia (ALL), but it is commonly associated with allergy, which results in morbidity and poorer outcomes. The underlying basis of this allergy is undoubtedly immune-mediated, but the exact components of T-cell immuni...

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Bibliographic Details
Main Authors: Shawn H. R. Lee, Zhenhua Li, Evelyn H. Z. Lim, Winnie H. N. Chin, Nan Jiang, Kean Hui Chiew, Zhiwei Chen, Bernice L. Z. Oh, Ah Moy Tan, Hany Ariffin, Jun J. Yang, Allen E. J. Yeoh
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
T-cell receptor repertoire
L-asparaginase
allergy
hypersensitivity
childhood acute lymphoblastic leukemia
Online Access:https://www.mdpi.com/2072-6694/15/6/1829

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