Screening of the antimalarial activity of plants of the Cucurbitaceae family
Crude ethanolic extracts (CEEs) from two species of Cucurbitaceae, Cucurbita maxima and Momordica charantia (commonly called "abóbora moranga" and melão de São Caetano", respectively) were assayed for antimalarial activity by the 4-d suppressive test. The CEE of dry C. maxima seeds sh...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1991-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600040 |
| _version_ | 1797756618055614464 |
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| author | Cláudia Zuany Amorim Arthur Diaz Marques Renato Sergio Balão Cordeiro |
| author_facet | Cláudia Zuany Amorim Arthur Diaz Marques Renato Sergio Balão Cordeiro |
| author_sort | Cláudia Zuany Amorim |
| collection | DOAJ |
| description | Crude ethanolic extracts (CEEs) from two species of Cucurbitaceae, Cucurbita maxima and Momordica charantia (commonly called "abóbora moranga" and melão de São Caetano", respectively) were assayed for antimalarial activity by the 4-d suppressive test. The CEE of dry C. maxima seeds showed strong antimalarial activity following oral administration (259 and 500 mg/kg), reducing by 50% the levels of parasistemia in Plasmodium berghey-infected mice. Treatment of normal animals with 500 mg/Kg of the extract three days before intravenous injection of P. berghei caused a significant 30% reduction in parasitemic levels. No effect was observed when the animals were treated with the CEE only on the day of inoculation. Oral administration of the CEE of dry M. charantia leaves adminstered orally was ineffective up to 500 mg/Kg in lowering the parasitemic levels of malarious mice. |
| first_indexed | 2024-03-12T18:03:13Z |
| format | Article |
| id | doaj.art-1fe589deebad42ec8f08abb3e2ab6011 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:03:13Z |
| publishDate | 1991-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-1fe589deebad42ec8f08abb3e2ab60112023-08-02T09:32:21ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601991-01-018617718010.1590/S0074-02761991000600040Screening of the antimalarial activity of plants of the Cucurbitaceae familyCláudia Zuany AmorimArthur Diaz MarquesRenato Sergio Balão CordeiroCrude ethanolic extracts (CEEs) from two species of Cucurbitaceae, Cucurbita maxima and Momordica charantia (commonly called "abóbora moranga" and melão de São Caetano", respectively) were assayed for antimalarial activity by the 4-d suppressive test. The CEE of dry C. maxima seeds showed strong antimalarial activity following oral administration (259 and 500 mg/kg), reducing by 50% the levels of parasistemia in Plasmodium berghey-infected mice. Treatment of normal animals with 500 mg/Kg of the extract three days before intravenous injection of P. berghei caused a significant 30% reduction in parasitemic levels. No effect was observed when the animals were treated with the CEE only on the day of inoculation. Oral administration of the CEE of dry M. charantia leaves adminstered orally was ineffective up to 500 mg/Kg in lowering the parasitemic levels of malarious mice.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600040antimalarialsdrug therapynatural productsplant extractsdrug screeningPlasmodium bergheicurcubita maximaMomordica charantiaCucurbitaceae |
| spellingShingle | Cláudia Zuany Amorim Arthur Diaz Marques Renato Sergio Balão Cordeiro Screening of the antimalarial activity of plants of the Cucurbitaceae family Memorias do Instituto Oswaldo Cruz antimalarials drug therapy natural products plant extracts drug screening Plasmodium berghei curcubita maxima Momordica charantia Cucurbitaceae |
| title | Screening of the antimalarial activity of plants of the Cucurbitaceae family |
| title_full | Screening of the antimalarial activity of plants of the Cucurbitaceae family |
| title_fullStr | Screening of the antimalarial activity of plants of the Cucurbitaceae family |
| title_full_unstemmed | Screening of the antimalarial activity of plants of the Cucurbitaceae family |
| title_short | Screening of the antimalarial activity of plants of the Cucurbitaceae family |
| title_sort | screening of the antimalarial activity of plants of the cucurbitaceae family |
| topic | antimalarials drug therapy natural products plant extracts drug screening Plasmodium berghei curcubita maxima Momordica charantia Cucurbitaceae |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600040 |
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