Foamy Virus Biology and Its Application for Vector Development
Spuma- or foamy viruses (FV), endemic in most non-human primates, cats, cattle and horses, comprise a special type of retrovirus that has developed a replication strategy combining features of both retroviruses and hepadnaviruses. Unique features of FVs include an apparent apathogenicity in natural...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-05-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/3/5/561/ |
| _version_ | 1817996931369009152 |
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| author | Axel Rethwilm Dirk Lindemann |
| author_facet | Axel Rethwilm Dirk Lindemann |
| author_sort | Axel Rethwilm |
| collection | DOAJ |
| description | Spuma- or foamy viruses (FV), endemic in most non-human primates, cats, cattle and horses, comprise a special type of retrovirus that has developed a replication strategy combining features of both retroviruses and hepadnaviruses. Unique features of FVs include an apparent apathogenicity in natural hosts as well as zoonotically infected humans, a reverse transcription of the packaged viral RNA genome late during viral replication resulting in an infectious DNA genome in released FV particles and a special particle release strategy depending capsid and glycoprotein coexpression and specific interaction between both components. In addition, particular features with respect to the integration profile into the host genomic DNA discriminate FV from orthoretroviruses. It appears that some inherent properties of FV vectors set them favorably apart from orthoretroviral vectors and ask for additional basic research on the viruses as well as on the application in Gene Therapy. This review will summarize the current knowledge of FV biology and the development as a gene transfer system. |
| first_indexed | 2024-04-14T02:30:43Z |
| format | Article |
| id | doaj.art-1fe884cd950f4b01a3d68671d9273780 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-14T02:30:43Z |
| publishDate | 2011-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-1fe884cd950f4b01a3d68671d92737802022-12-22T02:17:42ZengMDPI AGViruses1999-49152011-05-013556158510.3390/v3050561Foamy Virus Biology and Its Application for Vector DevelopmentAxel RethwilmDirk LindemannSpuma- or foamy viruses (FV), endemic in most non-human primates, cats, cattle and horses, comprise a special type of retrovirus that has developed a replication strategy combining features of both retroviruses and hepadnaviruses. Unique features of FVs include an apparent apathogenicity in natural hosts as well as zoonotically infected humans, a reverse transcription of the packaged viral RNA genome late during viral replication resulting in an infectious DNA genome in released FV particles and a special particle release strategy depending capsid and glycoprotein coexpression and specific interaction between both components. In addition, particular features with respect to the integration profile into the host genomic DNA discriminate FV from orthoretroviruses. It appears that some inherent properties of FV vectors set them favorably apart from orthoretroviral vectors and ask for additional basic research on the viruses as well as on the application in Gene Therapy. This review will summarize the current knowledge of FV biology and the development as a gene transfer system.http://www.mdpi.com/1999-4915/3/5/561/Foamyvirusesretroviral vectorsLADFanconi Anemia |
| spellingShingle | Axel Rethwilm Dirk Lindemann Foamy Virus Biology and Its Application for Vector Development Viruses Foamyviruses retroviral vectors LAD Fanconi Anemia |
| title | Foamy Virus Biology and Its Application for Vector Development |
| title_full | Foamy Virus Biology and Its Application for Vector Development |
| title_fullStr | Foamy Virus Biology and Its Application for Vector Development |
| title_full_unstemmed | Foamy Virus Biology and Its Application for Vector Development |
| title_short | Foamy Virus Biology and Its Application for Vector Development |
| title_sort | foamy virus biology and its application for vector development |
| topic | Foamyviruses retroviral vectors LAD Fanconi Anemia |
| url | http://www.mdpi.com/1999-4915/3/5/561/ |
| work_keys_str_mv | AT axelrethwilm foamyvirusbiologyanditsapplicationforvectordevelopment AT dirklindemann foamyvirusbiologyanditsapplicationforvectordevelopment |