In vivo bronchodilator evaluation of the ethanolic extract of the stems of Jatropha macrantha Müll.Arg.
Context: Asthma is characterized by hyperresponsiveness and bronchoconstriction, induced by histamine and other noxes, with a prevalence in Peru of 20.7-28.2%, which is why, in traditional medicine, Jatropha macrantha Müll.Arg is used. Aims: To evaluate the in vivo bronchodilator activity of the...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
GarVal Editorial Ltda.
2021-11-01
|
| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | https://jppres.com/jppres/pdf/vol9/jppres21.1109_9.6.937.pdf |
| _version_ | 1811273046917382144 |
|---|---|
| author | Haydee Chávez Freddy Palomino Jackeline Angelino Ernesto Torres María R. Bendezú Jorge A. García Berta Loja Ana M. Muñoz Angel T. Alvarado |
| author_facet | Haydee Chávez Freddy Palomino Jackeline Angelino Ernesto Torres María R. Bendezú Jorge A. García Berta Loja Ana M. Muñoz Angel T. Alvarado |
| author_sort | Haydee Chávez |
| collection | DOAJ |
| description | Context: Asthma is characterized by hyperresponsiveness and bronchoconstriction, induced by histamine and other noxes, with a prevalence in Peru of 20.7-28.2%, which is why, in traditional medicine, Jatropha macrantha Müll.Arg is used.
Aims: To evaluate the in vivo bronchodilator activity of the ethanolic extract of the stems of J. macrantha.
Methods: The powdered material of the stem of J. macrantha was extracted with ethanol 96° by maceration; then, the phytochemical screening was carried out. The doses of 200, 400 and 800 mg/kg of the extracts were subjected to in vivo evaluation in guinea pigs (Cavia porcellus) with 1% histamine-induced bronchoconstriction, determining the latency period and the intensity of the effect.
Results: Phytochemical sieving showed alkaloids, catechins, flavonoids, tannins and terpenes. The activity was observed at the three doses of the J. macrantha extract, being higher at a single dose of 400 mg/kg, with a latency period of 33.0 ± 1.02 s, asphyxia 84.5 ± 1.08 s and anaphylaxis 105.6 ± 0.59 s. The analysis of variance and Dunnett’s test resulted with p<0.05 as statistically significant.
Conclusions: The results showed bronchodilator activity of the ethanolic extract of J. macrantha at an average dose of 400 mg/kg, orally, in Cavia porcellus. |
| first_indexed | 2024-04-12T22:51:01Z |
| format | Article |
| id | doaj.art-1fe8b2eda4ed489d8a600948808fc367 |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-04-12T22:51:01Z |
| publishDate | 2021-11-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-1fe8b2eda4ed489d8a600948808fc3672022-12-22T03:13:20ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502021-11-0196937946In vivo bronchodilator evaluation of the ethanolic extract of the stems of Jatropha macrantha Müll.Arg.Haydee Chávez0Freddy Palomino1Jackeline Angelino2Ernesto Torres3María R. Bendezú4Jorge A. García5Berta Loja6Ana M. Muñoz7Angel T. Alvarado8Faculty of Pharmacy and Biochemistry, San Luis Gonzaga National University of Ica, Ica, Peru.Faculty of Pharmacy and Biochemistry, San Luis Gonzaga National University of Ica, Ica, Peru.Faculty of Pharmacy and Biochemistry, San Luis Gonzaga National University of Ica, Ica, Peru.Faculty of Pharmacy and Biochemistry, San Luis Gonzaga National University of Ica, Ica, Peru.Faculty of Pharmacy and Biochemistry, San Luis Gonzaga National University of Ica, Ica, Peru.Faculty of Pharmacy and Biochemistry, San Luis Gonzaga National University of Ica, Ica, Peru.Faculty of Pharmacy and Biochemistry, San Luis Gonzaga National University of Ica, Ica, Peru.Research Unit in Nutrition, Health, Functional Foods and Nutraceuticals, San Ignacio de Loyola University, Lima, Peru.International Research Network of Pharmacology and Precision Medicine (REDIFMEP), San Ignacio de Loyola University, Lima, Peru.Context: Asthma is characterized by hyperresponsiveness and bronchoconstriction, induced by histamine and other noxes, with a prevalence in Peru of 20.7-28.2%, which is why, in traditional medicine, Jatropha macrantha Müll.Arg is used. Aims: To evaluate the in vivo bronchodilator activity of the ethanolic extract of the stems of J. macrantha. Methods: The powdered material of the stem of J. macrantha was extracted with ethanol 96° by maceration; then, the phytochemical screening was carried out. The doses of 200, 400 and 800 mg/kg of the extracts were subjected to in vivo evaluation in guinea pigs (Cavia porcellus) with 1% histamine-induced bronchoconstriction, determining the latency period and the intensity of the effect. Results: Phytochemical sieving showed alkaloids, catechins, flavonoids, tannins and terpenes. The activity was observed at the three doses of the J. macrantha extract, being higher at a single dose of 400 mg/kg, with a latency period of 33.0 ± 1.02 s, asphyxia 84.5 ± 1.08 s and anaphylaxis 105.6 ± 0.59 s. The analysis of variance and Dunnett’s test resulted with p<0.05 as statistically significant. Conclusions: The results showed bronchodilator activity of the ethanolic extract of J. macrantha at an average dose of 400 mg/kg, orally, in Cavia porcellus.https://jppres.com/jppres/pdf/vol9/jppres21.1109_9.6.937.pdfjatropha macranthahuanarpo femalebronchodilator activity |
| spellingShingle | Haydee Chávez Freddy Palomino Jackeline Angelino Ernesto Torres María R. Bendezú Jorge A. García Berta Loja Ana M. Muñoz Angel T. Alvarado In vivo bronchodilator evaluation of the ethanolic extract of the stems of Jatropha macrantha Müll.Arg. Journal of Pharmacy & Pharmacognosy Research jatropha macrantha huanarpo female bronchodilator activity |
| title | In vivo bronchodilator evaluation of the ethanolic extract of the stems of Jatropha macrantha Müll.Arg. |
| title_full | In vivo bronchodilator evaluation of the ethanolic extract of the stems of Jatropha macrantha Müll.Arg. |
| title_fullStr | In vivo bronchodilator evaluation of the ethanolic extract of the stems of Jatropha macrantha Müll.Arg. |
| title_full_unstemmed | In vivo bronchodilator evaluation of the ethanolic extract of the stems of Jatropha macrantha Müll.Arg. |
| title_short | In vivo bronchodilator evaluation of the ethanolic extract of the stems of Jatropha macrantha Müll.Arg. |
| title_sort | in vivo bronchodilator evaluation of the ethanolic extract of the stems of jatropha macrantha mull arg |
| topic | jatropha macrantha huanarpo female bronchodilator activity |
| url | https://jppres.com/jppres/pdf/vol9/jppres21.1109_9.6.937.pdf |
| work_keys_str_mv | AT haydeechavez invivobronchodilatorevaluationoftheethanolicextractofthestemsofjatrophamacranthamullarg AT freddypalomino invivobronchodilatorevaluationoftheethanolicextractofthestemsofjatrophamacranthamullarg AT jackelineangelino invivobronchodilatorevaluationoftheethanolicextractofthestemsofjatrophamacranthamullarg AT ernestotorres invivobronchodilatorevaluationoftheethanolicextractofthestemsofjatrophamacranthamullarg AT mariarbendezu invivobronchodilatorevaluationoftheethanolicextractofthestemsofjatrophamacranthamullarg AT jorgeagarcia invivobronchodilatorevaluationoftheethanolicextractofthestemsofjatrophamacranthamullarg AT bertaloja invivobronchodilatorevaluationoftheethanolicextractofthestemsofjatrophamacranthamullarg AT anammunoz invivobronchodilatorevaluationoftheethanolicextractofthestemsofjatrophamacranthamullarg AT angeltalvarado invivobronchodilatorevaluationoftheethanolicextractofthestemsofjatrophamacranthamullarg |