Application Prospect of Induced Pluripotent Stem Cells in Organoids and Cell Therapy
Since its inception, induced pluripotent stem cell (iPSC) technology has been hailed as a powerful tool for comprehending disease etiology and advancing drug screening across various domains. While earlier iPSC-based disease modeling and drug assessment primarily operated at the cellular level, rece...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/5/2680 |
| _version_ | 1797264418231287808 |
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| author | Teng Zhang Cheng Qian Mengyao Song Yu Tang Yueke Zhou Guanglu Dong Qiuhong Shen Wenxing Chen Aiyun Wang Sanbing Shen Yang Zhao Yin Lu |
| author_facet | Teng Zhang Cheng Qian Mengyao Song Yu Tang Yueke Zhou Guanglu Dong Qiuhong Shen Wenxing Chen Aiyun Wang Sanbing Shen Yang Zhao Yin Lu |
| author_sort | Teng Zhang |
| collection | DOAJ |
| description | Since its inception, induced pluripotent stem cell (iPSC) technology has been hailed as a powerful tool for comprehending disease etiology and advancing drug screening across various domains. While earlier iPSC-based disease modeling and drug assessment primarily operated at the cellular level, recent years have witnessed a significant shift towards organoid-based investigations. Organoids derived from iPSCs offer distinct advantages, particularly in enabling the observation of disease progression and drug metabolism in an in vivo-like environment, surpassing the capabilities of iPSC-derived cells. Furthermore, iPSC-based cell therapy has emerged as a focal point of clinical interest. In this review, we provide an extensive overview of non-integrative reprogramming methods that have evolved since the inception of iPSC technology. We also deliver a comprehensive examination of iPSC-derived organoids, spanning the realms of the nervous system, cardiovascular system, and oncology, as well as systematically elucidate recent advancements in iPSC-related cell therapies. |
| first_indexed | 2024-04-25T00:28:35Z |
| format | Article |
| id | doaj.art-1fea1867ef52443fb027561fb160ddd1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-25T00:28:35Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1fea1867ef52443fb027561fb160ddd12024-03-12T16:45:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01255268010.3390/ijms25052680Application Prospect of Induced Pluripotent Stem Cells in Organoids and Cell TherapyTeng Zhang0Cheng Qian1Mengyao Song2Yu Tang3Yueke Zhou4Guanglu Dong5Qiuhong Shen6Wenxing Chen7Aiyun Wang8Sanbing Shen9Yang Zhao10Yin Lu11Jiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaRegenerative Medicine Institute, School of Medicine, University of Galway, H91 W2TY Galway, IrelandJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaSince its inception, induced pluripotent stem cell (iPSC) technology has been hailed as a powerful tool for comprehending disease etiology and advancing drug screening across various domains. While earlier iPSC-based disease modeling and drug assessment primarily operated at the cellular level, recent years have witnessed a significant shift towards organoid-based investigations. Organoids derived from iPSCs offer distinct advantages, particularly in enabling the observation of disease progression and drug metabolism in an in vivo-like environment, surpassing the capabilities of iPSC-derived cells. Furthermore, iPSC-based cell therapy has emerged as a focal point of clinical interest. In this review, we provide an extensive overview of non-integrative reprogramming methods that have evolved since the inception of iPSC technology. We also deliver a comprehensive examination of iPSC-derived organoids, spanning the realms of the nervous system, cardiovascular system, and oncology, as well as systematically elucidate recent advancements in iPSC-related cell therapies.https://www.mdpi.com/1422-0067/25/5/2680induced pluripotent stem cellsreprogrammingdisease modelingcell therapyorganoidsregenerative medicine |
| spellingShingle | Teng Zhang Cheng Qian Mengyao Song Yu Tang Yueke Zhou Guanglu Dong Qiuhong Shen Wenxing Chen Aiyun Wang Sanbing Shen Yang Zhao Yin Lu Application Prospect of Induced Pluripotent Stem Cells in Organoids and Cell Therapy International Journal of Molecular Sciences induced pluripotent stem cells reprogramming disease modeling cell therapy organoids regenerative medicine |
| title | Application Prospect of Induced Pluripotent Stem Cells in Organoids and Cell Therapy |
| title_full | Application Prospect of Induced Pluripotent Stem Cells in Organoids and Cell Therapy |
| title_fullStr | Application Prospect of Induced Pluripotent Stem Cells in Organoids and Cell Therapy |
| title_full_unstemmed | Application Prospect of Induced Pluripotent Stem Cells in Organoids and Cell Therapy |
| title_short | Application Prospect of Induced Pluripotent Stem Cells in Organoids and Cell Therapy |
| title_sort | application prospect of induced pluripotent stem cells in organoids and cell therapy |
| topic | induced pluripotent stem cells reprogramming disease modeling cell therapy organoids regenerative medicine |
| url | https://www.mdpi.com/1422-0067/25/5/2680 |
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