Fluxomics - New Metabolomics Approaches to Monitor Metabolic Pathways
Fluxomics is an innovative -omics research field that measures the rates of all intracellular fluxes in the central metabolism of biological systems. Fluxomics gathers data from multiple different -omics fields, portraying the whole picture of molecular interactions. Recently, fluxomics has become o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.805782/full |
| _version_ | 1818306250305175552 |
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| author | Abdul-Hamid Emwas Kacper Szczepski Inas Al-Younis Joanna Izabela Lachowicz Mariusz Jaremko |
| author_facet | Abdul-Hamid Emwas Kacper Szczepski Inas Al-Younis Joanna Izabela Lachowicz Mariusz Jaremko |
| author_sort | Abdul-Hamid Emwas |
| collection | DOAJ |
| description | Fluxomics is an innovative -omics research field that measures the rates of all intracellular fluxes in the central metabolism of biological systems. Fluxomics gathers data from multiple different -omics fields, portraying the whole picture of molecular interactions. Recently, fluxomics has become one of the most relevant approaches to investigate metabolic phenotypes. Metabolic flux using 13C-labeled molecules is increasingly used to monitor metabolic pathways, to probe the corresponding gene-RNA and protein-metabolite interaction networks in actual time. Thus, fluxomics reveals the functioning of multi-molecular metabolic pathways and is increasingly applied in biotechnology and pharmacology. Here, we describe the main fluxomics approaches and experimental platforms. Moreover, we summarize recent fluxomic results in different biological systems. |
| first_indexed | 2024-12-13T06:39:30Z |
| format | Article |
| id | doaj.art-1feaecb3ad65480a848ae6ee9ee5a6d9 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T06:39:30Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-1feaecb3ad65480a848ae6ee9ee5a6d92022-12-21T23:56:27ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-03-011310.3389/fphar.2022.805782805782Fluxomics - New Metabolomics Approaches to Monitor Metabolic PathwaysAbdul-Hamid Emwas0Kacper Szczepski1Inas Al-Younis2Joanna Izabela Lachowicz3Mariusz Jaremko4King Abdullah University of Science and Technology, Core Labs, Thuwal, Saudi ArabiaSmart-Health Initiative (SHI) and Red Sea Research Center (RSRC), Biological and Environmental Sciences & Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi ArabiaKing Abdullah University of Science and Technology (KAUST), Biological and Environmental Sciences & Engineering Division (BESE), Thuwal, Saudi ArabiaDepartment of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria, Monserrato, ItalySmart-Health Initiative (SHI) and Red Sea Research Center (RSRC), Biological and Environmental Sciences & Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi ArabiaFluxomics is an innovative -omics research field that measures the rates of all intracellular fluxes in the central metabolism of biological systems. Fluxomics gathers data from multiple different -omics fields, portraying the whole picture of molecular interactions. Recently, fluxomics has become one of the most relevant approaches to investigate metabolic phenotypes. Metabolic flux using 13C-labeled molecules is increasingly used to monitor metabolic pathways, to probe the corresponding gene-RNA and protein-metabolite interaction networks in actual time. Thus, fluxomics reveals the functioning of multi-molecular metabolic pathways and is increasingly applied in biotechnology and pharmacology. Here, we describe the main fluxomics approaches and experimental platforms. Moreover, we summarize recent fluxomic results in different biological systems.https://www.frontiersin.org/articles/10.3389/fphar.2022.805782/fullfluxomicsmetabolomicsnuclear magnetic resonance (NMR)mass spectrometry (MS)fluxpharmacometabolomics |
| spellingShingle | Abdul-Hamid Emwas Kacper Szczepski Inas Al-Younis Joanna Izabela Lachowicz Mariusz Jaremko Fluxomics - New Metabolomics Approaches to Monitor Metabolic Pathways Frontiers in Pharmacology fluxomics metabolomics nuclear magnetic resonance (NMR) mass spectrometry (MS) flux pharmacometabolomics |
| title | Fluxomics - New Metabolomics Approaches to Monitor Metabolic Pathways |
| title_full | Fluxomics - New Metabolomics Approaches to Monitor Metabolic Pathways |
| title_fullStr | Fluxomics - New Metabolomics Approaches to Monitor Metabolic Pathways |
| title_full_unstemmed | Fluxomics - New Metabolomics Approaches to Monitor Metabolic Pathways |
| title_short | Fluxomics - New Metabolomics Approaches to Monitor Metabolic Pathways |
| title_sort | fluxomics new metabolomics approaches to monitor metabolic pathways |
| topic | fluxomics metabolomics nuclear magnetic resonance (NMR) mass spectrometry (MS) flux pharmacometabolomics |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.805782/full |
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