Identification of Somatic Mitochondrial DNA Mutations, Heteroplasmy, and Increased Levels of Catenanes in Tumor Specimens Obtained from Three Endometrial Cancer Patients

Identification of Somatic Mitochondrial DNA Mutations, Heteroplasmy, and Increased Levels of Catenanes in Tumor Specimens Obtained from Three Endometrial Cancer Patients

Endometrial carcinoma (EC) is the most common type of gynecologic malignant epithelial tumor, with the death rate from this disease doubling over the past 20 years. Mitochondria provide cancer cells with necessary anabolic building blocks such as amino acids, lipids, and nucleotides, and EC samples...

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Bibliographic Details
Main Authors: Matthew J. Young, Ravi Sachidanandam, Dale B. Hales, Laurent Brard, Kathy Robinson, Md. Mostafijur Rahman, Pabitra Khadka, Kathleen Groesch, Carolyn K. J. Young
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Life
Subjects:
uterine cancer
endometrial cancer
human mitochondrial DNA (mtDNA) maintenance
homoplasmy
heteroplasmy
somatic mutations
Online Access:https://www.mdpi.com/2075-1729/12/4/562

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