Prevention of Inflammation, Neovascularization, and Retinal Dysfunction by Kinin B<sub>1</sub> Receptor Antagonism in a Mouse Model of Age-Related Macular Degeneration

Prevention of Inflammation, Neovascularization, and Retinal Dysfunction by Kinin B<sub>1</sub> Receptor Antagonism in a Mouse Model of Age-Related Macular Degeneration

The kallikrein-kinin system (KKS) contributes to vascular inflammation and neovascularization in age-related macular degeneration (AMD), particularly via the kinin B<sub>1</sub> receptor (B<sub>1</sub>R). The aim of the present study was to determine the protective effects of...

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Bibliographic Details
Main Authors: Menakshi Bhat, Shima Shirzad, Abdel-Rahamane Kader Fofana, Fernand Gobeil, Réjean Couture, Elvire Vaucher
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Journal of Clinical Medicine
Subjects:
age-related macular degeneration
kallikrein-kinin system
kinin B<sub>1</sub> receptor
electroretinography
neovascularization
inflammation
Online Access:https://www.mdpi.com/2077-0383/12/19/6213

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