Planning in silico screening and experimental study of the hypoglycemic derivatives of cyclic guanidines
This article is devoted to the search for new cyclic guanidine derivatives with hypoglycemic activity by means of in silico methods. The results of computer prediction of hypoglycemic effect for nine classes of these compounds were analyzed. Two perspective classes of cyclic guanidine derivatives ha...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2014-12-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/229 |
| _version_ | 1797295590290227200 |
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| author | P. M. Vasiliev A. A. Spasov K. V. Lenskaya V. V. Poroikov D. A. Filimonov V. A. Anisimova |
| author_facet | P. M. Vasiliev A. A. Spasov K. V. Lenskaya V. V. Poroikov D. A. Filimonov V. A. Anisimova |
| author_sort | P. M. Vasiliev |
| collection | DOAJ |
| description | This article is devoted to the search for new cyclic guanidine derivatives with hypoglycemic activity by means of in silico methods. The results of computer prediction of hypoglycemic effect for nine classes of these compounds were analyzed. Two perspective classes of cyclic guanidine derivatives have been identified. Planning in silico screening was performed and new unstudied substances were tested. |
| first_indexed | 2024-03-07T21:50:09Z |
| format | Article |
| id | doaj.art-1fee039c1de94f5381876ec166cf7484 |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2024-03-07T21:50:09Z |
| publishDate | 2014-12-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-1fee039c1de94f5381876ec166cf74842024-02-25T10:57:15ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442014-12-016111510.25207/1608-6228-2014-6-11-15229Planning in silico screening and experimental study of the hypoglycemic derivatives of cyclic guanidinesP. M. Vasiliev0A. A. Spasov1K. V. Lenskaya2V. V. Poroikov3D. A. Filimonov4V. A. Anisimova5Волгоградский государственный медицинский университетВолгоградский государственный медицинский университетВолгоградский государственный медицинский университетНИИ биомедицинской химии им.В.Н. ОреховичаНИИ биомедицинской химии им.В.Н. ОреховичаНИИ физической и органической химии Южного федерального университетаThis article is devoted to the search for new cyclic guanidine derivatives with hypoglycemic activity by means of in silico methods. The results of computer prediction of hypoglycemic effect for nine classes of these compounds were analyzed. Two perspective classes of cyclic guanidine derivatives have been identified. Planning in silico screening was performed and new unstudied substances were tested.https://ksma.elpub.ru/jour/article/view/229циклические гуанидиныгипогликемическая активностьметоды in silicoдиабеткомпьютерное планирование экспериментовcyclic guanidineshypoglycemic activityin silico methodsdiabetescomputer planning of experiments |
| spellingShingle | P. M. Vasiliev A. A. Spasov K. V. Lenskaya V. V. Poroikov D. A. Filimonov V. A. Anisimova Planning in silico screening and experimental study of the hypoglycemic derivatives of cyclic guanidines Кубанский научный медицинский вестник циклические гуанидины гипогликемическая активность методы in silico диабет компьютерное планирование экспериментов cyclic guanidines hypoglycemic activity in silico methods diabetes computer planning of experiments |
| title | Planning in silico screening and experimental study of the hypoglycemic derivatives of cyclic guanidines |
| title_full | Planning in silico screening and experimental study of the hypoglycemic derivatives of cyclic guanidines |
| title_fullStr | Planning in silico screening and experimental study of the hypoglycemic derivatives of cyclic guanidines |
| title_full_unstemmed | Planning in silico screening and experimental study of the hypoglycemic derivatives of cyclic guanidines |
| title_short | Planning in silico screening and experimental study of the hypoglycemic derivatives of cyclic guanidines |
| title_sort | planning in silico screening and experimental study of the hypoglycemic derivatives of cyclic guanidines |
| topic | циклические гуанидины гипогликемическая активность методы in silico диабет компьютерное планирование экспериментов cyclic guanidines hypoglycemic activity in silico methods diabetes computer planning of experiments |
| url | https://ksma.elpub.ru/jour/article/view/229 |
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