A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone
7-Methyljuglone (7-MJ) is a pure compound isolated from the roots of <i>Euclea natalensis</i> A. DC., a shrub indigenous to South Africa. It exhibits significant promise as a potential treatment for the highly communicable disease tuberculosis (TB), owing to its effective antimycobacteri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/2/216 |
| _version_ | 1797297182907301888 |
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| author | Bianca Diedericks Anna-Mari Kok Vusani Mandiwana Namrita Lall |
| author_facet | Bianca Diedericks Anna-Mari Kok Vusani Mandiwana Namrita Lall |
| author_sort | Bianca Diedericks |
| collection | DOAJ |
| description | 7-Methyljuglone (7-MJ) is a pure compound isolated from the roots of <i>Euclea natalensis</i> A. DC., a shrub indigenous to South Africa. It exhibits significant promise as a potential treatment for the highly communicable disease tuberculosis (TB), owing to its effective antimycobacterial activity against <i>Mycobacterium tuberculosis</i>. Despite its potential therapeutic benefits, 7-MJ has demonstrated in vitro cytotoxicity against various cancerous and non-cancerous cell lines, raising concerns about its safety for consumption by TB patients. Therefore, this review focuses on exploring the potential of poly-(lactide-co-glycolic) acid (PLGA) nanoparticles as a delivery system, which has been shown to decrease in vitro cytotoxicity, and 7-MJ as an effective antimycobacterial compound. |
| first_indexed | 2024-03-07T22:17:36Z |
| format | Article |
| id | doaj.art-1feeebba50304df6a3d54c88c40ed141 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-07T22:17:36Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-1feeebba50304df6a3d54c88c40ed1412024-02-23T15:31:07ZengMDPI AGPharmaceutics1999-49232024-02-0116221610.3390/pharmaceutics16020216A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-MethyljugloneBianca Diedericks0Anna-Mari Kok1Vusani Mandiwana2Namrita Lall3Department of Plant and Soil Sciences, University of Pretoria, Pretoria 0002, South AfricaDepartment of Plant and Soil Sciences, University of Pretoria, Pretoria 0002, South AfricaChemicals Cluster, Centre for Nanostructures and Advanced Materials, Council for Scientific and Industrial Research, Pretoria 0001, South AfricaDepartment of Plant and Soil Sciences, University of Pretoria, Pretoria 0002, South Africa7-Methyljuglone (7-MJ) is a pure compound isolated from the roots of <i>Euclea natalensis</i> A. DC., a shrub indigenous to South Africa. It exhibits significant promise as a potential treatment for the highly communicable disease tuberculosis (TB), owing to its effective antimycobacterial activity against <i>Mycobacterium tuberculosis</i>. Despite its potential therapeutic benefits, 7-MJ has demonstrated in vitro cytotoxicity against various cancerous and non-cancerous cell lines, raising concerns about its safety for consumption by TB patients. Therefore, this review focuses on exploring the potential of poly-(lactide-co-glycolic) acid (PLGA) nanoparticles as a delivery system, which has been shown to decrease in vitro cytotoxicity, and 7-MJ as an effective antimycobacterial compound.https://www.mdpi.com/1999-4923/16/2/216tuberculosis (TB)antimycobacterialcytotoxicity7-methyljuglonepoly-(lactide-co-glycolide) (PLGA)nanoparticle |
| spellingShingle | Bianca Diedericks Anna-Mari Kok Vusani Mandiwana Namrita Lall A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone Pharmaceutics tuberculosis (TB) antimycobacterial cytotoxicity 7-methyljuglone poly-(lactide-co-glycolide) (PLGA) nanoparticle |
| title | A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone |
| title_full | A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone |
| title_fullStr | A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone |
| title_full_unstemmed | A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone |
| title_short | A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone |
| title_sort | review of the potential of poly lactide co glycolide nanoparticles as a delivery system for an active antimycobacterial compound 7 methyljuglone |
| topic | tuberculosis (TB) antimycobacterial cytotoxicity 7-methyljuglone poly-(lactide-co-glycolide) (PLGA) nanoparticle |
| url | https://www.mdpi.com/1999-4923/16/2/216 |
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