Chronic social stress during early development elicits unique behavioral changes in adulthood
Purpose Chronic social stress is known to induce inflammation in the brain, and early-life stress affects the brain and social behavior in adulthood. To study the relationship between social stress in childhood development and social behavior in adulthood, we subjected mice to a sequential early-lif...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Encephalitis and Neuroinflammation Society
2022-04-01
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| Series: | Encephalitis |
| Subjects: | |
| Online Access: | http://www.encephalitisjournal.org/upload/pdf/encephalitis-2021-00178.pdf |
| _version_ | 1811178043826241536 |
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| author | Daejong Jeon Jiye Choi Ah Reum Yang Jung-Seok Yoo Sangwoo Kim Sang Kun Lee Kon Chu |
| author_facet | Daejong Jeon Jiye Choi Ah Reum Yang Jung-Seok Yoo Sangwoo Kim Sang Kun Lee Kon Chu |
| author_sort | Daejong Jeon |
| collection | DOAJ |
| description | Purpose Chronic social stress is known to induce inflammation in the brain, and early-life stress affects the brain and social behavior in adulthood. To study the relationship between social stress in childhood development and social behavior in adulthood, we subjected mice to a sequential early-life social stresses and characterized their adult behavioral phenotypes. Methods C57BL/6 mice were sequentially subjected to maternal separation (MS), social defeat (SD), and social isolation (SI) in that order. The body weights of the MS/SD/SI mice were measured. Behavioral tasks related to anxiety, depression, locomotion, learning/memory, and repetitive/compulsive-like behavior were conducted. Social behaviors suggesting sociability, social interaction, aggression, and social fear were investigated. Results MS/SD/SI mice weighed less than the control mice. At 7 and 8 weeks of age. These mice displayed normal behaviors in anxiety-, depression-, and learning/memory-related tasks, but they exhibited increased locomotor activity and a low level of repetitive/compulsive-like behavior. Notably, they exhibited increased social interaction, impaired empathy-related fear, reduced predator fear, and increased defensive aggressiveness. Conclusion Social stress during childhood development resulted in behavioral alterations, and MS/SD/SI mice generated by mimicking child abuse or maltreatment showed unique abnormalities in social behaviors. MS/SD/SI mice might be useful not only to study the relationship between social stress and brain inflammation but also psychosocial behaviors observed in individuals with brain disorders, such as psychopaths. |
| first_indexed | 2024-04-11T06:11:37Z |
| format | Article |
| id | doaj.art-1ff1f329df32409f9c086cd78978d2e1 |
| institution | Directory Open Access Journal |
| issn | 2765-4559 2734-1461 |
| language | English |
| last_indexed | 2024-04-11T06:11:37Z |
| publishDate | 2022-04-01 |
| publisher | Korean Encephalitis and Neuroinflammation Society |
| record_format | Article |
| series | Encephalitis |
| spelling | doaj.art-1ff1f329df32409f9c086cd78978d2e12022-12-22T04:41:14ZengKorean Encephalitis and Neuroinflammation SocietyEncephalitis2765-45592734-14612022-04-0122455310.47936/encephalitis.2021.0017833Chronic social stress during early development elicits unique behavioral changes in adulthoodDaejong Jeon0Jiye Choi1Ah Reum Yang2Jung-Seok Yoo3Sangwoo Kim4Sang Kun Lee5Kon Chu6 Advanced Neural Technologies, Co., Seoul, Korea Korea Advanced Institute of Science and Technology, Daejeon, Korea Laboratory for Neurotherapeutics, Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea Laboratory for Neurotherapeutics, Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea Laboratory for Neurotherapeutics, Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea Laboratory for Neurotherapeutics, Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea Laboratory for Neurotherapeutics, Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, KoreaPurpose Chronic social stress is known to induce inflammation in the brain, and early-life stress affects the brain and social behavior in adulthood. To study the relationship between social stress in childhood development and social behavior in adulthood, we subjected mice to a sequential early-life social stresses and characterized their adult behavioral phenotypes. Methods C57BL/6 mice were sequentially subjected to maternal separation (MS), social defeat (SD), and social isolation (SI) in that order. The body weights of the MS/SD/SI mice were measured. Behavioral tasks related to anxiety, depression, locomotion, learning/memory, and repetitive/compulsive-like behavior were conducted. Social behaviors suggesting sociability, social interaction, aggression, and social fear were investigated. Results MS/SD/SI mice weighed less than the control mice. At 7 and 8 weeks of age. These mice displayed normal behaviors in anxiety-, depression-, and learning/memory-related tasks, but they exhibited increased locomotor activity and a low level of repetitive/compulsive-like behavior. Notably, they exhibited increased social interaction, impaired empathy-related fear, reduced predator fear, and increased defensive aggressiveness. Conclusion Social stress during childhood development resulted in behavioral alterations, and MS/SD/SI mice generated by mimicking child abuse or maltreatment showed unique abnormalities in social behaviors. MS/SD/SI mice might be useful not only to study the relationship between social stress and brain inflammation but also psychosocial behaviors observed in individuals with brain disorders, such as psychopaths.http://www.encephalitisjournal.org/upload/pdf/encephalitis-2021-00178.pdfmicechildhood developmentsocial stresssocial behaviorabuse |
| spellingShingle | Daejong Jeon Jiye Choi Ah Reum Yang Jung-Seok Yoo Sangwoo Kim Sang Kun Lee Kon Chu Chronic social stress during early development elicits unique behavioral changes in adulthood Encephalitis mice childhood development social stress social behavior abuse |
| title | Chronic social stress during early development elicits unique behavioral changes in adulthood |
| title_full | Chronic social stress during early development elicits unique behavioral changes in adulthood |
| title_fullStr | Chronic social stress during early development elicits unique behavioral changes in adulthood |
| title_full_unstemmed | Chronic social stress during early development elicits unique behavioral changes in adulthood |
| title_short | Chronic social stress during early development elicits unique behavioral changes in adulthood |
| title_sort | chronic social stress during early development elicits unique behavioral changes in adulthood |
| topic | mice childhood development social stress social behavior abuse |
| url | http://www.encephalitisjournal.org/upload/pdf/encephalitis-2021-00178.pdf |
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