Out-of-hospital cardiac arrest complicated by hyperthermia
Background: The aims of this study were to establish epidemiology, clinical management and outcomes in cases of adult out-of-hospital cardiac arrest complicated by hyperthermia attended by the London Ambulance Service NHS Trust between January 2018 and December 2019. Where evidence is available in r...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Resuscitation Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666520422001333 |
| _version_ | 1811199361941504000 |
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| author | Timothy Edwards Paul Rees |
| author_facet | Timothy Edwards Paul Rees |
| author_sort | Timothy Edwards |
| collection | DOAJ |
| description | Background: The aims of this study were to establish epidemiology, clinical management and outcomes in cases of adult out-of-hospital cardiac arrest complicated by hyperthermia attended by the London Ambulance Service NHS Trust between January 2018 and December 2019. Where evidence is available in relation to this sub-set of cardiac arrest patients it is generally limited to small case series and we therefore we sought to improve knowledge and target therapeutic interventions. Methods and results: Retrospective analysis of 253 cases was undertaken following abstraction from an established cardiac arrest database. Age ranged from 18-99 years with a median of 72 years (IQR 28) and 53.4% (n = 135) of patients were female. Overall thirty-day mortality was 94.5% (n = 239), with 48.2% (n = 122) of patients recognised life extinct in the out-of-hospital phase following termination of resuscitation. No significant differences in clinical characteristics stratified according to temperature group were identified. The presumed aetiology was infective in 62.8% (n = 159) of patients, and due to drug ingestion or heat illness in 7.5% (n = 19) and 2% (n = 5) respectively. In the remaining cases (27.7%, n = 70) it was not possible to determine the likely cause of the arrest. Conclusions: Previous research relating to cardiac arrest complicated by hyperthermia is limited to case reports and small case series, suggesting that the current study represents the most comprehensive analysis of this sub-group of out-of-hospital cardiac arrest patients currently available. Most cases were associated with evidence of infection compared with drug related aetiologies and heat illness. Where indicated, cooling was applied infrequently using inconsistent methods. |
| first_indexed | 2024-04-12T01:46:53Z |
| format | Article |
| id | doaj.art-1ff250e2292c49b088d8151416f79dcc |
| institution | Directory Open Access Journal |
| issn | 2666-5204 |
| language | English |
| last_indexed | 2024-04-12T01:46:53Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Resuscitation Plus |
| spelling | doaj.art-1ff250e2292c49b088d8151416f79dcc2022-12-22T03:53:02ZengElsevierResuscitation Plus2666-52042022-12-0112100333Out-of-hospital cardiac arrest complicated by hyperthermiaTimothy Edwards0Paul Rees1London Ambulance Service NHS Trust, 220 Waterloo Road, London SE1 8SD, United Kingdom; Corresponding author.St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, United KingdomBackground: The aims of this study were to establish epidemiology, clinical management and outcomes in cases of adult out-of-hospital cardiac arrest complicated by hyperthermia attended by the London Ambulance Service NHS Trust between January 2018 and December 2019. Where evidence is available in relation to this sub-set of cardiac arrest patients it is generally limited to small case series and we therefore we sought to improve knowledge and target therapeutic interventions. Methods and results: Retrospective analysis of 253 cases was undertaken following abstraction from an established cardiac arrest database. Age ranged from 18-99 years with a median of 72 years (IQR 28) and 53.4% (n = 135) of patients were female. Overall thirty-day mortality was 94.5% (n = 239), with 48.2% (n = 122) of patients recognised life extinct in the out-of-hospital phase following termination of resuscitation. No significant differences in clinical characteristics stratified according to temperature group were identified. The presumed aetiology was infective in 62.8% (n = 159) of patients, and due to drug ingestion or heat illness in 7.5% (n = 19) and 2% (n = 5) respectively. In the remaining cases (27.7%, n = 70) it was not possible to determine the likely cause of the arrest. Conclusions: Previous research relating to cardiac arrest complicated by hyperthermia is limited to case reports and small case series, suggesting that the current study represents the most comprehensive analysis of this sub-group of out-of-hospital cardiac arrest patients currently available. Most cases were associated with evidence of infection compared with drug related aetiologies and heat illness. Where indicated, cooling was applied infrequently using inconsistent methods.http://www.sciencedirect.com/science/article/pii/S2666520422001333Cardiac arrestHyperthermiaPrehospitalEmergency medical services |
| spellingShingle | Timothy Edwards Paul Rees Out-of-hospital cardiac arrest complicated by hyperthermia Resuscitation Plus Cardiac arrest Hyperthermia Prehospital Emergency medical services |
| title | Out-of-hospital cardiac arrest complicated by hyperthermia |
| title_full | Out-of-hospital cardiac arrest complicated by hyperthermia |
| title_fullStr | Out-of-hospital cardiac arrest complicated by hyperthermia |
| title_full_unstemmed | Out-of-hospital cardiac arrest complicated by hyperthermia |
| title_short | Out-of-hospital cardiac arrest complicated by hyperthermia |
| title_sort | out of hospital cardiac arrest complicated by hyperthermia |
| topic | Cardiac arrest Hyperthermia Prehospital Emergency medical services |
| url | http://www.sciencedirect.com/science/article/pii/S2666520422001333 |
| work_keys_str_mv | AT timothyedwards outofhospitalcardiacarrestcomplicatedbyhyperthermia AT paulrees outofhospitalcardiacarrestcomplicatedbyhyperthermia |