THE EFFICACY OF MELDONIUM IN REDUCTION OF CARDIAC ELECTRICAL INSTABILITY IN PATIENTS WITH ISCHEMIC STROKE
<p>Aim. To study meldonium effect in the combination therapy for ventricular repolarization disorders and cardiac electrical instability in patients with ischemic stroke.</p><p>Material and methods. Patients (n=46) with acute phase of ischemic stroke were included in a randomized,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | http://www.rpcardio.ru/jour/article/view/137 |
| Summary: | <p>Aim. To study meldonium effect in the combination therapy for ventricular repolarization disorders and cardiac electrical instability in patients with ischemic stroke.</p><p>Material and methods. Patients (n=46) with acute phase of ischemic stroke were included in a randomized, open-label, uncontrolled study. Patients were randomized into two groups. Group 1 patients (n=25) had been receiving meldonium (Mildronate;Grindex,Latvia;Pharmstandard,Russia), 1.0 g/day intravenously once daily, as a part of standard therapy for 10 days since admission to the hospital. Group 2 patients (n=21) had standard therapy alone. A standart 12-lead ECG, ventricular late potentials (VLP), 24-hour Holter monitoring, troponin test were performed at the baseline and after 10 days.</p><p>Results. Patients of the group 1 as compared to the group 2 demonstrated more significant positive effect on the clinical condition of patients with ischemic stroke, ventricular repolarization, reduction of frequency (from 3.7±0.5 to 2.1±0.4; p<0.05) and duration (from 6.6±1, 3 to 4.0±1.1 min; p<0.05) of painless myocardial ischemia episodes and VLP (from 48 to 32%).</p><p>Conclusion. Adding meldonium to standard therapy in patients with acute phase of ischemic stroke can have a positive effect on the clinical condition, repolarization disorders on ECG, frequency of VLP and episodes of painless myocardial ischemia detection. This may have a positive effect on the electrical stability and prevention of cardiac arrhythmias. </p> |
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| ISSN: | 1819-6446 2225-3653 |