Effect of <i>TRPM8</i> and <i>TRPA1</i> Polymorphisms on COPD Predisposition and Lung Function in COPD Patients
Certain transient receptor potential (TRP) channels including <i>TRPM8</i> and <i>TRPA1</i> are widely expressed in the respiratory tract and have been shown to be the receptors of cigarette smoke and particulate matter—the main causative factors of chronic obstructive pulmon...
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MDPI AG
2021-02-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/2/108 |
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| author | Denis E. Naumov Olesya O. Kotova Dina A. Gassan Ivana Y. Sugaylo Evgeniya Y. Afanas’eva Elizaveta G. Sheludko Juliy M. Perelman |
| author_facet | Denis E. Naumov Olesya O. Kotova Dina A. Gassan Ivana Y. Sugaylo Evgeniya Y. Afanas’eva Elizaveta G. Sheludko Juliy M. Perelman |
| author_sort | Denis E. Naumov |
| collection | DOAJ |
| description | Certain transient receptor potential (TRP) channels including <i>TRPM8</i> and <i>TRPA1</i> are widely expressed in the respiratory tract and have been shown to be the receptors of cigarette smoke and particulate matter—the main causative factors of chronic obstructive pulmonary disease (COPD). The aim of the study was to investigate the effect of <i>TRPM8</i> and <i>TRPA1</i> polymorphisms on COPD predisposition and lung function in COPD patients. The study enrolled 143 COPD patients and 104 smokers with post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) > 70%. Lung function was measured by spirometry. <i>TRPM8</i> and <i>TRPA1</i> polymorphisms were genotyped by LATE-PCR. None of the polymorphisms significantly influenced COPD predisposition after correction for covariates and multiple testing. Among COPD patients, the TT genotype of <i>TRPA1</i> rs7819749 was significantly associated with higher degree of bronchial obstruction. In addition, we established that carriers of the C allele of <i>TRPM8</i> rs11562975 more commonly had post-bronchodilator FEV1 < 60% (OR 3.2, 95%CI (1.14–8.94), <i>p</i> = 0.03) and revealed the effect of <i>TRPA1</i> rs959976 and <i>TRPM8</i> rs17865682 on bronchodilator response in COPD. Thus, the obtained results suggest possible involvement of <i>TRPM8</i> and <i>TRPA1</i> in COPD pathogenesis, indicating the necessity to further investigate their functional role in this pathology. |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T05:07:47Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-1ff54dd20fb64bc9aa2f2db8256c5d7f2023-12-03T12:52:55ZengMDPI AGJournal of Personalized Medicine2075-44262021-02-0111210810.3390/jpm11020108Effect of <i>TRPM8</i> and <i>TRPA1</i> Polymorphisms on COPD Predisposition and Lung Function in COPD PatientsDenis E. Naumov0Olesya O. Kotova1Dina A. Gassan2Ivana Y. Sugaylo3Evgeniya Y. Afanas’eva4Elizaveta G. Sheludko5Juliy M. Perelman6Far Eastern Scientific Center of Physiology and Pathology of Respiration, Laboratory of Molecular and Translational Research, 675000 Blagoveshchensk, RussiaFar Eastern Scientific Center of Physiology and Pathology of Respiration, Laboratory of Molecular and Translational Research, 675000 Blagoveshchensk, RussiaFar Eastern Scientific Center of Physiology and Pathology of Respiration, Laboratory of Molecular and Translational Research, 675000 Blagoveshchensk, RussiaFar Eastern Scientific Center of Physiology and Pathology of Respiration, Laboratory of Molecular and Translational Research, 675000 Blagoveshchensk, RussiaFar Eastern Scientific Center of Physiology and Pathology of Respiration, Laboratory of Molecular and Translational Research, 675000 Blagoveshchensk, RussiaFar Eastern Scientific Center of Physiology and Pathology of Respiration, Laboratory of Molecular and Translational Research, 675000 Blagoveshchensk, RussiaFar Eastern Scientific Center of Physiology and Pathology of Respiration, Laboratory of Functional Research of the Respiratory System, 675000 Blagoveshchensk, RussiaCertain transient receptor potential (TRP) channels including <i>TRPM8</i> and <i>TRPA1</i> are widely expressed in the respiratory tract and have been shown to be the receptors of cigarette smoke and particulate matter—the main causative factors of chronic obstructive pulmonary disease (COPD). The aim of the study was to investigate the effect of <i>TRPM8</i> and <i>TRPA1</i> polymorphisms on COPD predisposition and lung function in COPD patients. The study enrolled 143 COPD patients and 104 smokers with post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) > 70%. Lung function was measured by spirometry. <i>TRPM8</i> and <i>TRPA1</i> polymorphisms were genotyped by LATE-PCR. None of the polymorphisms significantly influenced COPD predisposition after correction for covariates and multiple testing. Among COPD patients, the TT genotype of <i>TRPA1</i> rs7819749 was significantly associated with higher degree of bronchial obstruction. In addition, we established that carriers of the C allele of <i>TRPM8</i> rs11562975 more commonly had post-bronchodilator FEV1 < 60% (OR 3.2, 95%CI (1.14–8.94), <i>p</i> = 0.03) and revealed the effect of <i>TRPA1</i> rs959976 and <i>TRPM8</i> rs17865682 on bronchodilator response in COPD. Thus, the obtained results suggest possible involvement of <i>TRPM8</i> and <i>TRPA1</i> in COPD pathogenesis, indicating the necessity to further investigate their functional role in this pathology.https://www.mdpi.com/2075-4426/11/2/108COPDlung functionsmokingTRPM8TRPA1polymorphism |
| spellingShingle | Denis E. Naumov Olesya O. Kotova Dina A. Gassan Ivana Y. Sugaylo Evgeniya Y. Afanas’eva Elizaveta G. Sheludko Juliy M. Perelman Effect of <i>TRPM8</i> and <i>TRPA1</i> Polymorphisms on COPD Predisposition and Lung Function in COPD Patients Journal of Personalized Medicine COPD lung function smoking TRPM8 TRPA1 polymorphism |
| title | Effect of <i>TRPM8</i> and <i>TRPA1</i> Polymorphisms on COPD Predisposition and Lung Function in COPD Patients |
| title_full | Effect of <i>TRPM8</i> and <i>TRPA1</i> Polymorphisms on COPD Predisposition and Lung Function in COPD Patients |
| title_fullStr | Effect of <i>TRPM8</i> and <i>TRPA1</i> Polymorphisms on COPD Predisposition and Lung Function in COPD Patients |
| title_full_unstemmed | Effect of <i>TRPM8</i> and <i>TRPA1</i> Polymorphisms on COPD Predisposition and Lung Function in COPD Patients |
| title_short | Effect of <i>TRPM8</i> and <i>TRPA1</i> Polymorphisms on COPD Predisposition and Lung Function in COPD Patients |
| title_sort | effect of i trpm8 i and i trpa1 i polymorphisms on copd predisposition and lung function in copd patients |
| topic | COPD lung function smoking TRPM8 TRPA1 polymorphism |
| url | https://www.mdpi.com/2075-4426/11/2/108 |
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