Effect of IMRT and three-dimensional conformal radiotherapy on oral Candida colonization: A comparative study
Aim: To investigate oral candidiasis in patients with head and neck cancer before and after intensity-modulated radiation therapy and three-dimensional conformal radiotherapy (3D CRT) and to explore if there is an association with the type of radiotherapy used and the severity of candidiasis. Materi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Oral Research and Review |
| Subjects: | |
| Online Access: | http://www.jorr.org/article.asp?issn=2249-4987;year=2017;volume=9;issue=2;spage=51;epage=55;aulast=Kamath |
| _version_ | 1818930880671907840 |
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| author | Jasmine Shanthi Kamath Raghavendra Kini Anup Kumar Shetty Vathsala Naik |
| author_facet | Jasmine Shanthi Kamath Raghavendra Kini Anup Kumar Shetty Vathsala Naik |
| author_sort | Jasmine Shanthi Kamath |
| collection | DOAJ |
| description | Aim: To investigate oral candidiasis in patients with head and neck cancer before and after intensity-modulated radiation therapy and three-dimensional conformal radiotherapy (3D CRT) and to explore if there is an association with the type of radiotherapy used and the severity of candidiasis.
Materials and Methods: Patients who received radiation therapy (RT) for the treatment of head and neck cancer were divided into two groups: Group 1 consisted of patients (n = 20) who received Intensity modulated radiation therapy (IMRT) and Group 2 (n = 20) consisted of patients who received 3D CRT. Saliva from these patients was collected before and after radiotherapy and evaluated for Candida species using culture method.
Results: Significant increase of Candida albicans was seen in patients who underwent 3D CRT as compared to IMRT. Other species of Candida such as Candida tropicalis, Candida glabrata, and Candida krusei showed increase postradiotherapy in both groups, but the change was not significant.
Conclusion: Although candidiasis is seen regardless of the type of radiation therapy used, the oral environment is more stable after intensity-modulated radiation therapy as and when compared to 3D CRT. Salivary substitutes and good oral hygiene before, during, and after radiotherapy could be used to increase oral clearance and to decrease the chance of candidiasis. |
| first_indexed | 2024-12-20T04:07:44Z |
| format | Article |
| id | doaj.art-1ff6a6d871314b84b5bbdf7e7f660bbb |
| institution | Directory Open Access Journal |
| issn | 2249-4987 2394-2541 |
| language | English |
| last_indexed | 2024-12-20T04:07:44Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Oral Research and Review |
| spelling | doaj.art-1ff6a6d871314b84b5bbdf7e7f660bbb2022-12-21T19:53:59ZengWolters Kluwer Medknow PublicationsJournal of Oral Research and Review2249-49872394-25412017-01-0192515510.4103/jorr.jorr_45_16Effect of IMRT and three-dimensional conformal radiotherapy on oral Candida colonization: A comparative studyJasmine Shanthi KamathRaghavendra KiniAnup Kumar ShettyVathsala NaikAim: To investigate oral candidiasis in patients with head and neck cancer before and after intensity-modulated radiation therapy and three-dimensional conformal radiotherapy (3D CRT) and to explore if there is an association with the type of radiotherapy used and the severity of candidiasis. Materials and Methods: Patients who received radiation therapy (RT) for the treatment of head and neck cancer were divided into two groups: Group 1 consisted of patients (n = 20) who received Intensity modulated radiation therapy (IMRT) and Group 2 (n = 20) consisted of patients who received 3D CRT. Saliva from these patients was collected before and after radiotherapy and evaluated for Candida species using culture method. Results: Significant increase of Candida albicans was seen in patients who underwent 3D CRT as compared to IMRT. Other species of Candida such as Candida tropicalis, Candida glabrata, and Candida krusei showed increase postradiotherapy in both groups, but the change was not significant. Conclusion: Although candidiasis is seen regardless of the type of radiation therapy used, the oral environment is more stable after intensity-modulated radiation therapy as and when compared to 3D CRT. Salivary substitutes and good oral hygiene before, during, and after radiotherapy could be used to increase oral clearance and to decrease the chance of candidiasis.http://www.jorr.org/article.asp?issn=2249-4987;year=2017;volume=9;issue=2;spage=51;epage=55;aulast=KamathCandidacandidiasishead and neck malignancyintensity-modulated radiotherapyradiotherapythree-dimensional conformal radiotherapy |
| spellingShingle | Jasmine Shanthi Kamath Raghavendra Kini Anup Kumar Shetty Vathsala Naik Effect of IMRT and three-dimensional conformal radiotherapy on oral Candida colonization: A comparative study Journal of Oral Research and Review Candida candidiasis head and neck malignancy intensity-modulated radiotherapy radiotherapy three-dimensional conformal radiotherapy |
| title | Effect of IMRT and three-dimensional conformal radiotherapy on oral Candida colonization: A comparative study |
| title_full | Effect of IMRT and three-dimensional conformal radiotherapy on oral Candida colonization: A comparative study |
| title_fullStr | Effect of IMRT and three-dimensional conformal radiotherapy on oral Candida colonization: A comparative study |
| title_full_unstemmed | Effect of IMRT and three-dimensional conformal radiotherapy on oral Candida colonization: A comparative study |
| title_short | Effect of IMRT and three-dimensional conformal radiotherapy on oral Candida colonization: A comparative study |
| title_sort | effect of imrt and three dimensional conformal radiotherapy on oral candida colonization a comparative study |
| topic | Candida candidiasis head and neck malignancy intensity-modulated radiotherapy radiotherapy three-dimensional conformal radiotherapy |
| url | http://www.jorr.org/article.asp?issn=2249-4987;year=2017;volume=9;issue=2;spage=51;epage=55;aulast=Kamath |
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