Pulmonary 99mTc-HMDP uptake correlates with restrictive ventilatory defects and abnormal lung reactance in transthyretin cardiac amyloidosis patients
Abstract Background Pulmonary involvement in individuals with transthyretin cardiac amyloidosis is unclear. The aim of this study was to quantify 99mTc-hydroxy methylene diphosphonate (HMDP) lung retention in hereditary transthyretin (ATTRv) cardiac amyloidosis patients and to relate tracer uptake i...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | Respiratory Research |
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| Online Access: | https://doi.org/10.1186/s12931-022-01995-x |
| _version_ | 1797630005751054336 |
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| author | Astrid Monfort Alexia Rivas Rishika Banydeen Jocelyn Inamo Karim Farid Remi Neviere |
| author_facet | Astrid Monfort Alexia Rivas Rishika Banydeen Jocelyn Inamo Karim Farid Remi Neviere |
| author_sort | Astrid Monfort |
| collection | DOAJ |
| description | Abstract Background Pulmonary involvement in individuals with transthyretin cardiac amyloidosis is unclear. The aim of this study was to quantify 99mTc-hydroxy methylene diphosphonate (HMDP) lung retention in hereditary transthyretin (ATTRv) cardiac amyloidosis patients and to relate tracer uptake intensity to pulmonary function and aerobic capacity. Methods We prospectively enrolled 20 patients with biopsy-proven ATTRv cardiac amyloidosis and 20 control subjects. Cardiac involvement was confirmed by echocardiography and nuclear imaging using 99mTc-HMDP. Semi-quantitative analysis of the heart, rib and lung retention was assessed using a simple region of interest technique. Pulmonary function was evaluation by the means of whole-body plethysmography, diffusing capacity of the lung for carbon monoxide, forced oscillation technique and cardiopulmonary exercise testing. Results Pulmonary tracer uptake estimated by lung to rib retention ratio was higher in ATTRv amyloidosis patients compared with control subjects: median 0.62 (0.55–0.69) vs 0.51 (0.46–0.60); p = 0.014. Analysis of relation between lung 99mTc-HMDP retention and pulmonary function parameters shown statistically significant correlations with total lung volume (% predicted), lung reactance (Xrs 5 Hz) and peak VO2, suggesting total lung capacity restriction impaired elastic properties of the lung and poor aerobic capacity. Conclusion Our study suggests that some grade of pulmonary retention of 99mTc-HMDP may occur in patients with cardiac ATTRv amyloidosis, which can elicit deleterious effects on patient’s lung function and aerobic capacity. |
| first_indexed | 2024-03-11T11:00:52Z |
| format | Article |
| id | doaj.art-1ff70692a60841d98363fb9e65e401c7 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-03-11T11:00:52Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-1ff70692a60841d98363fb9e65e401c72023-11-12T12:27:42ZengBMCRespiratory Research1465-993X2022-03-012311810.1186/s12931-022-01995-xPulmonary 99mTc-HMDP uptake correlates with restrictive ventilatory defects and abnormal lung reactance in transthyretin cardiac amyloidosis patientsAstrid Monfort0Alexia Rivas1Rishika Banydeen2Jocelyn Inamo3Karim Farid4Remi Neviere5Department of Cardiology, CHU Martinique (University Hospital of Martinique)Department of Nuclear Medicine, CHU Martinique (University Hospital of Martinique)Department of Clinical Research, CHU Martinique (University Hospital of Martinique)Department of Cardiology, CHU Martinique (University Hospital of Martinique)Department of Nuclear Medicine, CHU Martinique (University Hospital of Martinique)Department of Cardiology, CHU Martinique (University Hospital of Martinique)Abstract Background Pulmonary involvement in individuals with transthyretin cardiac amyloidosis is unclear. The aim of this study was to quantify 99mTc-hydroxy methylene diphosphonate (HMDP) lung retention in hereditary transthyretin (ATTRv) cardiac amyloidosis patients and to relate tracer uptake intensity to pulmonary function and aerobic capacity. Methods We prospectively enrolled 20 patients with biopsy-proven ATTRv cardiac amyloidosis and 20 control subjects. Cardiac involvement was confirmed by echocardiography and nuclear imaging using 99mTc-HMDP. Semi-quantitative analysis of the heart, rib and lung retention was assessed using a simple region of interest technique. Pulmonary function was evaluation by the means of whole-body plethysmography, diffusing capacity of the lung for carbon monoxide, forced oscillation technique and cardiopulmonary exercise testing. Results Pulmonary tracer uptake estimated by lung to rib retention ratio was higher in ATTRv amyloidosis patients compared with control subjects: median 0.62 (0.55–0.69) vs 0.51 (0.46–0.60); p = 0.014. Analysis of relation between lung 99mTc-HMDP retention and pulmonary function parameters shown statistically significant correlations with total lung volume (% predicted), lung reactance (Xrs 5 Hz) and peak VO2, suggesting total lung capacity restriction impaired elastic properties of the lung and poor aerobic capacity. Conclusion Our study suggests that some grade of pulmonary retention of 99mTc-HMDP may occur in patients with cardiac ATTRv amyloidosis, which can elicit deleterious effects on patient’s lung function and aerobic capacity.https://doi.org/10.1186/s12931-022-01995-xTransthyretinCardiac amyloidosis99mTc-HMDPLung function testsAerobic capacity |
| spellingShingle | Astrid Monfort Alexia Rivas Rishika Banydeen Jocelyn Inamo Karim Farid Remi Neviere Pulmonary 99mTc-HMDP uptake correlates with restrictive ventilatory defects and abnormal lung reactance in transthyretin cardiac amyloidosis patients Respiratory Research Transthyretin Cardiac amyloidosis 99mTc-HMDP Lung function tests Aerobic capacity |
| title | Pulmonary 99mTc-HMDP uptake correlates with restrictive ventilatory defects and abnormal lung reactance in transthyretin cardiac amyloidosis patients |
| title_full | Pulmonary 99mTc-HMDP uptake correlates with restrictive ventilatory defects and abnormal lung reactance in transthyretin cardiac amyloidosis patients |
| title_fullStr | Pulmonary 99mTc-HMDP uptake correlates with restrictive ventilatory defects and abnormal lung reactance in transthyretin cardiac amyloidosis patients |
| title_full_unstemmed | Pulmonary 99mTc-HMDP uptake correlates with restrictive ventilatory defects and abnormal lung reactance in transthyretin cardiac amyloidosis patients |
| title_short | Pulmonary 99mTc-HMDP uptake correlates with restrictive ventilatory defects and abnormal lung reactance in transthyretin cardiac amyloidosis patients |
| title_sort | pulmonary 99mtc hmdp uptake correlates with restrictive ventilatory defects and abnormal lung reactance in transthyretin cardiac amyloidosis patients |
| topic | Transthyretin Cardiac amyloidosis 99mTc-HMDP Lung function tests Aerobic capacity |
| url | https://doi.org/10.1186/s12931-022-01995-x |
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