Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ 12,14 Prostaglandin J2-Sensitive Microglial Activation

Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ 12,14 Prostaglandin J2-Sensitive Microglial Activation

In Alzheimer’s disease, fibrillar amyloid-β (Aβ) peptides form senile plaques associated with microglia. However, the relationship between Aβ peptides and microglia is not fully understood. In this study, the incubation of Aβ1-40 (Aβ40) produced small oligomers, while incubation with Aβ1-42 (Aβ42) c...

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Bibliographic Details
Main Authors:	Kazuyuki Takata, Yoshihisa Kitamura, Masaaki Umeki, Daiju Tsuchiya, Jun-ichi Kakimura, Takashi Taniguchi, Peter J. Gebicke-Haerter, Shun Shimohama
Format:	Article
Language:	English
Published:	Elsevier 2003-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319327161

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