Microtechnology-based in vitro models: Mimicking liver function and pathophysiology
The liver plays important roles in drug metabolism and homeostasis. The metabolism and biotransformation can not only affect the efficacy of drugs but also result in hepatotoxicity and drug-induced liver injury. Understanding the complex physiology of the liver and the pathogenetic mechanisms of liv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2021-12-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/5.0061896 |
| _version_ | 1831715743623806976 |
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| author | Seung Yeon Lee Donghyun Kim Seung Hwan Lee Jong Hwan Sung |
| author_facet | Seung Yeon Lee Donghyun Kim Seung Hwan Lee Jong Hwan Sung |
| author_sort | Seung Yeon Lee |
| collection | DOAJ |
| description | The liver plays important roles in drug metabolism and homeostasis. The metabolism and biotransformation can not only affect the efficacy of drugs but also result in hepatotoxicity and drug-induced liver injury. Understanding the complex physiology of the liver and the pathogenetic mechanisms of liver diseases is essential for drug development. Conventional in vitro models have limitations in the ability to predict drug effects, due to the lack of physiological relevance. Recently, the liver-on-a-chip platform has been developed to reproduce the microarchitecture and in vivo environment of the liver. These efforts have improved the physiological relevance of the liver tissue used in the platform and have demonstrated its applicability to drug screening and disease models. In this review, we summarize the recent development of liver-on-a-chip models that closely mimic the in vivo liver environments and liver diseases. |
| first_indexed | 2024-12-21T00:25:04Z |
| format | Article |
| id | doaj.art-1ff853d3d16d4caa82afd3eb70a31903 |
| institution | Directory Open Access Journal |
| issn | 2473-2877 |
| language | English |
| last_indexed | 2024-12-21T00:25:04Z |
| publishDate | 2021-12-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Bioengineering |
| spelling | doaj.art-1ff853d3d16d4caa82afd3eb70a319032022-12-21T19:22:00ZengAIP Publishing LLCAPL Bioengineering2473-28772021-12-0154041505041505-1510.1063/5.0061896Microtechnology-based in vitro models: Mimicking liver function and pathophysiologySeung Yeon Lee0Donghyun Kim1Seung Hwan Lee2Jong Hwan Sung3 Department of Chemical Engineering, Hongik University, Seoul 04066, South Korea School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, South Korea Department of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan 15588, South Korea Department of Chemical Engineering, Hongik University, Seoul 04066, South KoreaThe liver plays important roles in drug metabolism and homeostasis. The metabolism and biotransformation can not only affect the efficacy of drugs but also result in hepatotoxicity and drug-induced liver injury. Understanding the complex physiology of the liver and the pathogenetic mechanisms of liver diseases is essential for drug development. Conventional in vitro models have limitations in the ability to predict drug effects, due to the lack of physiological relevance. Recently, the liver-on-a-chip platform has been developed to reproduce the microarchitecture and in vivo environment of the liver. These efforts have improved the physiological relevance of the liver tissue used in the platform and have demonstrated its applicability to drug screening and disease models. In this review, we summarize the recent development of liver-on-a-chip models that closely mimic the in vivo liver environments and liver diseases.http://dx.doi.org/10.1063/5.0061896 |
| spellingShingle | Seung Yeon Lee Donghyun Kim Seung Hwan Lee Jong Hwan Sung Microtechnology-based in vitro models: Mimicking liver function and pathophysiology APL Bioengineering |
| title | Microtechnology-based in vitro models: Mimicking liver function and pathophysiology |
| title_full | Microtechnology-based in vitro models: Mimicking liver function and pathophysiology |
| title_fullStr | Microtechnology-based in vitro models: Mimicking liver function and pathophysiology |
| title_full_unstemmed | Microtechnology-based in vitro models: Mimicking liver function and pathophysiology |
| title_short | Microtechnology-based in vitro models: Mimicking liver function and pathophysiology |
| title_sort | microtechnology based in vitro models mimicking liver function and pathophysiology |
| url | http://dx.doi.org/10.1063/5.0061896 |
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