Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery
In this study, chitosan particles were used to encapsulate marjoram phenolic compounds as colon-specific drug-delivery systems. The microparticles were prepared by ionic gelation and spray-drying techniques and varying amounts of polymer and extract, along with different method conditions. The spray...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/22/3657 |
| _version_ | 1797465282675998720 |
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| author | María de las Nieves Siles-Sánchez Laura Jaime Marisol Villalva Susana Santoyo |
| author_facet | María de las Nieves Siles-Sánchez Laura Jaime Marisol Villalva Susana Santoyo |
| author_sort | María de las Nieves Siles-Sánchez |
| collection | DOAJ |
| description | In this study, chitosan particles were used to encapsulate marjoram phenolic compounds as colon-specific drug-delivery systems. The microparticles were prepared by ionic gelation and spray-drying techniques and varying amounts of polymer and extract, along with different method conditions. The spray drying of microparticles (0.75% low molecular weight chitosan dissolved in 0.4% of acetic acid) presented the best encapsulation efficiency (near 75%), with size ranges from 1.55 to 1.68 µm that allowed the encapsulation of 1.25–1.88 mg/mL of extract. Release studies of individual marjoram phenolic compounds at pH 2 and 7.4 showed that most of the compounds remained encapsulated in the microparticles. Only arbutin and vicenin II presented a high initial burst release. As the polarity of the compounds was reduced, their initial release decreased. In addition, after gastrointestinal digestion, most of marjoram phenolic compounds remained encapsulated. These results prove that chitosan microparticlescould protect the marjoram phenolic compounds during gastrointestinal digestion, specifically those related to anticancer activity, which enables their application as colon-specific delivery systems. |
| first_indexed | 2024-03-09T18:20:18Z |
| format | Article |
| id | doaj.art-1ff9026584e94b79a1d90ff8c98bd0e7 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T18:20:18Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-1ff9026584e94b79a1d90ff8c98bd0e72023-11-24T08:22:14ZengMDPI AGFoods2304-81582022-11-011122365710.3390/foods11223657Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon DeliveryMaría de las Nieves Siles-Sánchez0Laura Jaime1Marisol Villalva2Susana Santoyo3Institute of Food Science and Research (CIAL), Universidad Autónoma de Madrid (CEI UAM + CSIC), 28049 Madrid, SpainInstitute of Food Science and Research (CIAL), Universidad Autónoma de Madrid (CEI UAM + CSIC), 28049 Madrid, SpainInstitute of Food Science and Research (CIAL), Universidad Autónoma de Madrid (CEI UAM + CSIC), 28049 Madrid, SpainInstitute of Food Science and Research (CIAL), Universidad Autónoma de Madrid (CEI UAM + CSIC), 28049 Madrid, SpainIn this study, chitosan particles were used to encapsulate marjoram phenolic compounds as colon-specific drug-delivery systems. The microparticles were prepared by ionic gelation and spray-drying techniques and varying amounts of polymer and extract, along with different method conditions. The spray drying of microparticles (0.75% low molecular weight chitosan dissolved in 0.4% of acetic acid) presented the best encapsulation efficiency (near 75%), with size ranges from 1.55 to 1.68 µm that allowed the encapsulation of 1.25–1.88 mg/mL of extract. Release studies of individual marjoram phenolic compounds at pH 2 and 7.4 showed that most of the compounds remained encapsulated in the microparticles. Only arbutin and vicenin II presented a high initial burst release. As the polarity of the compounds was reduced, their initial release decreased. In addition, after gastrointestinal digestion, most of marjoram phenolic compounds remained encapsulated. These results prove that chitosan microparticlescould protect the marjoram phenolic compounds during gastrointestinal digestion, specifically those related to anticancer activity, which enables their application as colon-specific delivery systems.https://www.mdpi.com/2304-8158/11/22/3657<i>Origanum majorana</i>phenolic compoundsnano/microparticlescolon delivery systemsionic gelationspray drying |
| spellingShingle | María de las Nieves Siles-Sánchez Laura Jaime Marisol Villalva Susana Santoyo Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery Foods <i>Origanum majorana</i> phenolic compounds nano/microparticles colon delivery systems ionic gelation spray drying |
| title | Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery |
| title_full | Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery |
| title_fullStr | Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery |
| title_full_unstemmed | Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery |
| title_short | Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery |
| title_sort | encapsulation of marjoram phenolic compounds using chitosan to improve its colon delivery |
| topic | <i>Origanum majorana</i> phenolic compounds nano/microparticles colon delivery systems ionic gelation spray drying |
| url | https://www.mdpi.com/2304-8158/11/22/3657 |
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