Imidazo[1,2-<i>a</i>]quinoxalines Derivatives Grafted with Amino Acids: Synthesis and Evaluation on A375 Melanoma Cells

Imidazo[1,2-<i>a</i>]quinoxalines Derivatives Grafted with Amino Acids: Synthesis and Evaluation on A375 Melanoma Cells

Imiqualines (imidazoquinoxaline derivatives) are anticancer compounds with high cytotoxic activities on melanoma cell lines. The first generation of imiqualines, with two lead compounds (EAPB0203 and EAPB0503), shows remarkable in vitro (IC<sub>50</sub> = 1 570 nM and IC<sub>50<...

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Bibliographic Details
Main Authors:	Adrien Chouchou, Cindy Patinote, Pierre Cuq, Pierre-Antoine Bonnet, Carine Deleuze-Masquéfa
Format:	Article
Language:	English
Published:	MDPI AG 2018-11-01
Series:	Molecules
Subjects:	imidazo[1,2-<i>a</i>]quinoxaline melanoma imiqualine A375 structure–activity relationship
Online Access:	https://www.mdpi.com/1420-3049/23/11/2987

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