Evaluation of 99mTc-HYNIC-TOC and 131I-MIBG imaging in diagnosis of pheochromocytoma and paraganglioma
Objective To evaluate 99mTc-HYNIC-TOC somatostatin receptor and 131I-MIBG imaging in clinical diag- nostic of pheochromocytoma and paraganglioma (PPGL). Methods This was a retrospective study.359 PPGL patients diagnosed by pathology microscopy were included. The diagnostic sensitivity and influenc...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2024-03-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-3-374.pdf |
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| author | WANG Yu, TONG Anli, ZHOU Yue, ZHANG Wenqian, CUI Yunying, JING Hongli , LI Yuxiu |
| author_facet | WANG Yu, TONG Anli, ZHOU Yue, ZHANG Wenqian, CUI Yunying, JING Hongli , LI Yuxiu |
| author_sort | WANG Yu, TONG Anli, ZHOU Yue, ZHANG Wenqian, CUI Yunying, JING Hongli , LI Yuxiu |
| collection | DOAJ |
| description | Objective To evaluate 99mTc-HYNIC-TOC somatostatin receptor and 131I-MIBG imaging in clinical diag- nostic of pheochromocytoma and paraganglioma (PPGL). Methods This was a retrospective study.359 PPGL patients diagnosed by pathology microscopy were included. The diagnostic sensitivity and influencing factors on 99mTc-HYNIC-TOC somatostatin receptor and 131I-MIBG imaging were analyzed. Results The positive rate of 99mTc-HYNIC-TOC somatostatin receptor scintigraphy was 57.7%(184/319)and 131I-MIBG imaging was 83.2%(232/279). The positive rates of 99mTc-HYNIC-TOC somatostatin receptor imaging in the adrenal glands, retroperitoneum, head and neck, heart and mediastinum, pelvis and bladder were 53.3%, 62.5%, 95.0%, 66.7%, 50.0% and 11.0% respectively and the positive rates of 131I-MIBG imaging were 86.7%, 88.5%, 45.4%, 50.0% ,75.0% and 33.3% respectively. The positive rate of the two imaging did not showed difference among patients with different genetic backgrounds (SDH,VHL,RET mutations). The median maximum diameter of tumors was 4.4(3.0, 6.1)cm.and the diagnostic sensitivity of somatostatin receptor imaging and 131I-MIBG imaging for larger tumors(≥4.4 cm) was significantly higher than those for the smaller tumor group (＜4.4 cm) (64.0% vs. 51.3%; 92.3% vs. 74.1%)(P＜0.01). Tumors in 19 patients (5.3%) failed to uptake neither imaging method. Conclusions This is the largest PPGL cohort in China concerning 99mTc-HYNIC-TOC somatostatin receptor imaging and 131I-MIBG imaging. The sensitivity of131I-MIBG imaging is higher than that of 99mTc-HYNIC-TOC somatostatin receptor imaging, but for some tumors, such as head and neck paraganglioma, the latter has obvious advantages. These two imagings technologies are complementary and the choice of them should depend the individual situation of patients. |
| first_indexed | 2024-03-07T21:24:34Z |
| format | Article |
| id | doaj.art-1ffb396f938d42d7a6f76b8b46d807ae |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-07T21:24:34Z |
| publishDate | 2024-03-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-1ffb396f938d42d7a6f76b8b46d807ae2024-02-27T06:29:54ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252024-03-0144337437810.16352/j.issn.1001-6325.2024.03.0374Evaluation of 99mTc-HYNIC-TOC and 131I-MIBG imaging in diagnosis of pheochromocytoma and paragangliomaWANG Yu, TONG Anli, ZHOU Yue, ZHANG Wenqian, CUI Yunying, JING Hongli , LI Yuxiu01. Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission;3. Department of Nuclear Medicine, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730; ;2. Graduate School, Hebei North University, Zhangjiakou 075000, ChinaObjective To evaluate 99mTc-HYNIC-TOC somatostatin receptor and 131I-MIBG imaging in clinical diag- nostic of pheochromocytoma and paraganglioma (PPGL). Methods This was a retrospective study.359 PPGL patients diagnosed by pathology microscopy were included. The diagnostic sensitivity and influencing factors on 99mTc-HYNIC-TOC somatostatin receptor and 131I-MIBG imaging were analyzed. Results The positive rate of 99mTc-HYNIC-TOC somatostatin receptor scintigraphy was 57.7%(184/319)and 131I-MIBG imaging was 83.2%(232/279). The positive rates of 99mTc-HYNIC-TOC somatostatin receptor imaging in the adrenal glands, retroperitoneum, head and neck, heart and mediastinum, pelvis and bladder were 53.3%, 62.5%, 95.0%, 66.7%, 50.0% and 11.0% respectively and the positive rates of 131I-MIBG imaging were 86.7%, 88.5%, 45.4%, 50.0% ,75.0% and 33.3% respectively. The positive rate of the two imaging did not showed difference among patients with different genetic backgrounds (SDH,VHL,RET mutations). The median maximum diameter of tumors was 4.4(3.0, 6.1)cm.and the diagnostic sensitivity of somatostatin receptor imaging and 131I-MIBG imaging for larger tumors(≥4.4 cm) was significantly higher than those for the smaller tumor group (＜4.4 cm) (64.0% vs. 51.3%; 92.3% vs. 74.1%)(P＜0.01). Tumors in 19 patients (5.3%) failed to uptake neither imaging method. Conclusions This is the largest PPGL cohort in China concerning 99mTc-HYNIC-TOC somatostatin receptor imaging and 131I-MIBG imaging. The sensitivity of131I-MIBG imaging is higher than that of 99mTc-HYNIC-TOC somatostatin receptor imaging, but for some tumors, such as head and neck paraganglioma, the latter has obvious advantages. These two imagings technologies are complementary and the choice of them should depend the individual situation of patients.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-3-374.pdfpheochromocytoma|paraganglioma|99mtc-hynic-toc somatostatin receptor imaging|131i-mibg imaging|diagnostic sensitivity |
| spellingShingle | WANG Yu, TONG Anli, ZHOU Yue, ZHANG Wenqian, CUI Yunying, JING Hongli , LI Yuxiu Evaluation of 99mTc-HYNIC-TOC and 131I-MIBG imaging in diagnosis of pheochromocytoma and paraganglioma Jichu yixue yu linchuang pheochromocytoma|paraganglioma|99mtc-hynic-toc somatostatin receptor imaging|131i-mibg imaging|diagnostic sensitivity |
| title | Evaluation of 99mTc-HYNIC-TOC and 131I-MIBG imaging in diagnosis of pheochromocytoma and paraganglioma |
| title_full | Evaluation of 99mTc-HYNIC-TOC and 131I-MIBG imaging in diagnosis of pheochromocytoma and paraganglioma |
| title_fullStr | Evaluation of 99mTc-HYNIC-TOC and 131I-MIBG imaging in diagnosis of pheochromocytoma and paraganglioma |
| title_full_unstemmed | Evaluation of 99mTc-HYNIC-TOC and 131I-MIBG imaging in diagnosis of pheochromocytoma and paraganglioma |
| title_short | Evaluation of 99mTc-HYNIC-TOC and 131I-MIBG imaging in diagnosis of pheochromocytoma and paraganglioma |
| title_sort | evaluation of 99mtc hynic toc and 131i mibg imaging in diagnosis of pheochromocytoma and paraganglioma |
| topic | pheochromocytoma|paraganglioma|99mtc-hynic-toc somatostatin receptor imaging|131i-mibg imaging|diagnostic sensitivity |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-3-374.pdf |
| work_keys_str_mv | AT wangyutonganlizhouyuezhangwenqiancuiyunyingjinghongliliyuxiu evaluationof99mtchynictocand131imibgimagingindiagnosisofpheochromocytomaandparaganglioma |