Inferring condition-specific modulation of transcription factor activity in yeast through regulon-based analysis of genomewide expression.
A key goal of systems biology is to understand how genomewide mRNA expression levels are controlled by transcription factors (TFs) in a condition-specific fashion. TF activity is frequently modulated at the post-translational level through ligand binding, covalent modification, or changes in sub-cel...
Main Authors: | André Boorsma, Xiang-Jun Lu, Anna Zakrzewska, Frans M Klis, Harmen J Bussemaker |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-09-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2518834?pdf=render |
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