Static magnetic field stimulation over motor cortex modulates resting functional connectivity in humans
Abstract Focal application of transcranial static magnetic field stimulation (tSMS) over the human motor cortex induces local changes in cortical excitability. Whether tSMS can also induce distant network effects, and how these local and distant effects may vary over time, is currently unknown. In t...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11859-5 |
| _version_ | 1828792958149722112 |
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| author | Vanesa Soto-León Mabel Torres-Llacsa Laura Mordillo-Mateos Carmen Carrasco-López José A. Pineda-Pardo Ana I. Velasco Laura Abad-Toribio Jesús Tornero Guglielmo Foffani Bryan A. Strange Antonio Oliviero |
| author_facet | Vanesa Soto-León Mabel Torres-Llacsa Laura Mordillo-Mateos Carmen Carrasco-López José A. Pineda-Pardo Ana I. Velasco Laura Abad-Toribio Jesús Tornero Guglielmo Foffani Bryan A. Strange Antonio Oliviero |
| author_sort | Vanesa Soto-León |
| collection | DOAJ |
| description | Abstract Focal application of transcranial static magnetic field stimulation (tSMS) over the human motor cortex induces local changes in cortical excitability. Whether tSMS can also induce distant network effects, and how these local and distant effects may vary over time, is currently unknown. In this study, we applied 10 min tSMS over the left motor cortex of healthy subjects using a real/sham parallel design. To measure tSMS effects at the sensori-motor network level, we used resting-state fMRI. Real tSMS, but not sham, reduced functional connectivity within the stimulated sensori-motor network. This effect of tSMS showed time-dependency, returning to sham levels after the first 5 min of fMRI scanning. With 10 min real tSMS over the motor cortex we did not observe effects in other functional networks examined (default mode and visual system networks). In conclusion, 10 min of tSMS over a location within the sensori-motor network reduces functional connectivity within the same functional network. |
| first_indexed | 2024-12-12T03:17:36Z |
| format | Article |
| id | doaj.art-1fff17fee88142fe82224d9d2d106615 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T03:17:36Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1fff17fee88142fe82224d9d2d1066152022-12-22T00:40:14ZengNature PortfolioScientific Reports2045-23222022-05-0112111010.1038/s41598-022-11859-5Static magnetic field stimulation over motor cortex modulates resting functional connectivity in humansVanesa Soto-León0Mabel Torres-Llacsa1Laura Mordillo-Mateos2Carmen Carrasco-López3José A. Pineda-Pardo4Ana I. Velasco5Laura Abad-Toribio6Jesús Tornero7Guglielmo Foffani8Bryan A. Strange9Antonio Oliviero10FENNSI Group, Hospital Nacional de Parapléjicos, SESCAMFENNSI Group, Hospital Nacional de Parapléjicos, SESCAMFENNSI Group, Hospital Nacional de Parapléjicos, SESCAMFENNSI Group, Hospital Nacional de Parapléjicos, SESCAMHM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM HospitalesUniversidad Alfonso X El SabioUniversidad Alfonso X El SabioHospital Los MadroñosHM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM HospitalesLaboratory for Clinical Neuroscience, Centre of Biomedical Technology, Universidad Politécnica de MadridFENNSI Group, Hospital Nacional de Parapléjicos, SESCAMAbstract Focal application of transcranial static magnetic field stimulation (tSMS) over the human motor cortex induces local changes in cortical excitability. Whether tSMS can also induce distant network effects, and how these local and distant effects may vary over time, is currently unknown. In this study, we applied 10 min tSMS over the left motor cortex of healthy subjects using a real/sham parallel design. To measure tSMS effects at the sensori-motor network level, we used resting-state fMRI. Real tSMS, but not sham, reduced functional connectivity within the stimulated sensori-motor network. This effect of tSMS showed time-dependency, returning to sham levels after the first 5 min of fMRI scanning. With 10 min real tSMS over the motor cortex we did not observe effects in other functional networks examined (default mode and visual system networks). In conclusion, 10 min of tSMS over a location within the sensori-motor network reduces functional connectivity within the same functional network.https://doi.org/10.1038/s41598-022-11859-5 |
| spellingShingle | Vanesa Soto-León Mabel Torres-Llacsa Laura Mordillo-Mateos Carmen Carrasco-López José A. Pineda-Pardo Ana I. Velasco Laura Abad-Toribio Jesús Tornero Guglielmo Foffani Bryan A. Strange Antonio Oliviero Static magnetic field stimulation over motor cortex modulates resting functional connectivity in humans Scientific Reports |
| title | Static magnetic field stimulation over motor cortex modulates resting functional connectivity in humans |
| title_full | Static magnetic field stimulation over motor cortex modulates resting functional connectivity in humans |
| title_fullStr | Static magnetic field stimulation over motor cortex modulates resting functional connectivity in humans |
| title_full_unstemmed | Static magnetic field stimulation over motor cortex modulates resting functional connectivity in humans |
| title_short | Static magnetic field stimulation over motor cortex modulates resting functional connectivity in humans |
| title_sort | static magnetic field stimulation over motor cortex modulates resting functional connectivity in humans |
| url | https://doi.org/10.1038/s41598-022-11859-5 |
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