| Summary: | Shenghong Zhang,1– 3 Jiajia Zhang,1,3 Xin Fan,1,3 Hanhui Liu,1– 3 Mengqin Zhu,1– 3 Mengdie Yang,1,3 Xiaoyi Zhang,1,3 Han Zhang,1,3 Fei Yu1,3 1Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2Shanghai Clinical College, Anhui Medical University, Shanghai, People’s Republic of China; 3Institute of Nuclear Medicine, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Fei Yu, Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China, Tel +86-021-66302721, Fax +86-021-66300588, Email yufei_021@163.comAbstract: Ferroptosis is an iron-dependent form of regulated cell death (RCD), that is associated with peroxidative damage to cellular membranes. A promising therapeutic method is to target ferroptosis. Nanomaterial-induced ferroptosis attracts enormous attention. Nevertheless, there are still certain shortcomings in ferroptosis, such as inadequate triggered immunogenic cell death to suit clinical demands. Various investigations have indicated that ionizing radiation (IR) can further induce ferroptosis. Consequently, it is a potential strategy for cancer therapy that combines nanomaterials and IR to induce ferroptosis. Initially, we discuss various ferroptosis inducers based on nanomaterials in this review. Furthermore, mechanisms of IR-induced ferroptosis are briefly introduced. Ultimately, we assess the feasibility of combining nanomaterials with IR to induce ferroptosis, paving the way for future research.Keywords: radiation therapy, lipid peroxidation, ROS, nanoparticles, combined therapy
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