Relationship between weight-adjusted-waist index and erectile dysfunction in the United State: results from NHANES 2001-2004
ObjectiveThe purpose of this study is to examine the association between a novel adiposity parameter, the weight-adjusted-waist index (WWI), and erectile dysfunction (ED).MethodsAccording to National Health and Nutrition Examination Survey (NHANES) 2001-2004, a total of 3884 participants were catego...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1128076/full |
| _version_ | 1827959682977759232 |
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| author | Shangqi Cao Xu Hu Yanxiang Shao Yaohui Wang Yaxiong Tang Shangqing Ren Xiang Li |
| author_facet | Shangqi Cao Xu Hu Yanxiang Shao Yaohui Wang Yaxiong Tang Shangqing Ren Xiang Li |
| author_sort | Shangqi Cao |
| collection | DOAJ |
| description | ObjectiveThe purpose of this study is to examine the association between a novel adiposity parameter, the weight-adjusted-waist index (WWI), and erectile dysfunction (ED).MethodsAccording to National Health and Nutrition Examination Survey (NHANES) 2001-2004, a total of 3884 participants were categorized as ED and non-ED individuals. WWI was calculated as waist circumference (WC, cm) divided by the square root of weight (kg). Weighted univariable and multivariable logistic regression models were conducted to assess the correlation between WWI and ED. Smooth curve fitting was utilized to examine the linear association. The receiver operating characteristic (ROC) curve and DeLong et al.’s test were applied to compare the area under curve (AUC) value and predictive power among WWI, body mass index (BMI), and WC for ED.ResultsWWI was positively related to ED with the full adjustment [odds ratio (OR)=1.75, 95% confidence interval (95% CI): 1.32-2.32, p=0.002]. After converting WWI to a categorical variable by quartiles (Q1-Q4), compared to Q1 the highest WWI quartile was linked to an obviously increased likelihood of ED (OR=2.78, 95% CI: 1.39-5.59. p=0.010). Subgroup analysis revealed the stability of the independent positive relationship between WWI and ED. It was shown that WWI had a stronger prediction for ED (AUC=0.745) than BMI (AUC=0.528) and WC (AUC=0.609). Sensitivity analysis was performed to verify the significantly positive connection between WWI and stricter ED (OR=2.00, 95% CI: 1.36-2.94, p=0.003).ConclusionAn elevated WWI was related to higher risks of ED in the United State adults, and a stronger predictive power of WWI for ED was observed than BMI and WC. |
| first_indexed | 2024-04-09T15:57:00Z |
| format | Article |
| id | doaj.art-2001f2759c884f60855136132af8f4cb |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T15:57:00Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2001f2759c884f60855136132af8f4cb2023-04-25T14:40:55ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11280761128076Relationship between weight-adjusted-waist index and erectile dysfunction in the United State: results from NHANES 2001-2004Shangqi Cao0Xu Hu1Yanxiang Shao2Yaohui Wang3Yaxiong Tang4Shangqing Ren5Xiang Li6Institute of Urology, Department of Urology, West China Hospital, West China Medical School, Sichuan University, Chengdu, ChinaInstitute of Urology, Department of Urology, West China Hospital, West China Medical School, Sichuan University, Chengdu, ChinaInstitute of Urology, Department of Urology, West China Hospital, West China Medical School, Sichuan University, Chengdu, ChinaInstitute of Urology, Department of Urology, West China Hospital, West China Medical School, Sichuan University, Chengdu, ChinaInstitute of Urology, Department of Urology, West China Hospital, West China Medical School, Sichuan University, Chengdu, ChinaRobotic Minimally Invasive Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, ChinaInstitute of Urology, Department of Urology, West China Hospital, West China Medical School, Sichuan University, Chengdu, ChinaObjectiveThe purpose of this study is to examine the association between a novel adiposity parameter, the weight-adjusted-waist index (WWI), and erectile dysfunction (ED).MethodsAccording to National Health and Nutrition Examination Survey (NHANES) 2001-2004, a total of 3884 participants were categorized as ED and non-ED individuals. WWI was calculated as waist circumference (WC, cm) divided by the square root of weight (kg). Weighted univariable and multivariable logistic regression models were conducted to assess the correlation between WWI and ED. Smooth curve fitting was utilized to examine the linear association. The receiver operating characteristic (ROC) curve and DeLong et al.’s test were applied to compare the area under curve (AUC) value and predictive power among WWI, body mass index (BMI), and WC for ED.ResultsWWI was positively related to ED with the full adjustment [odds ratio (OR)=1.75, 95% confidence interval (95% CI): 1.32-2.32, p=0.002]. After converting WWI to a categorical variable by quartiles (Q1-Q4), compared to Q1 the highest WWI quartile was linked to an obviously increased likelihood of ED (OR=2.78, 95% CI: 1.39-5.59. p=0.010). Subgroup analysis revealed the stability of the independent positive relationship between WWI and ED. It was shown that WWI had a stronger prediction for ED (AUC=0.745) than BMI (AUC=0.528) and WC (AUC=0.609). Sensitivity analysis was performed to verify the significantly positive connection between WWI and stricter ED (OR=2.00, 95% CI: 1.36-2.94, p=0.003).ConclusionAn elevated WWI was related to higher risks of ED in the United State adults, and a stronger predictive power of WWI for ED was observed than BMI and WC.https://www.frontiersin.org/articles/10.3389/fendo.2023.1128076/fullthe weight-adjusted-waist indexerectile dysfunctionobesityNational Health and Nutrition Examination Surveycross-sectional study |
| spellingShingle | Shangqi Cao Xu Hu Yanxiang Shao Yaohui Wang Yaxiong Tang Shangqing Ren Xiang Li Relationship between weight-adjusted-waist index and erectile dysfunction in the United State: results from NHANES 2001-2004 Frontiers in Endocrinology the weight-adjusted-waist index erectile dysfunction obesity National Health and Nutrition Examination Survey cross-sectional study |
| title | Relationship between weight-adjusted-waist index and erectile dysfunction in the United State: results from NHANES 2001-2004 |
| title_full | Relationship between weight-adjusted-waist index and erectile dysfunction in the United State: results from NHANES 2001-2004 |
| title_fullStr | Relationship between weight-adjusted-waist index and erectile dysfunction in the United State: results from NHANES 2001-2004 |
| title_full_unstemmed | Relationship between weight-adjusted-waist index and erectile dysfunction in the United State: results from NHANES 2001-2004 |
| title_short | Relationship between weight-adjusted-waist index and erectile dysfunction in the United State: results from NHANES 2001-2004 |
| title_sort | relationship between weight adjusted waist index and erectile dysfunction in the united state results from nhanes 2001 2004 |
| topic | the weight-adjusted-waist index erectile dysfunction obesity National Health and Nutrition Examination Survey cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1128076/full |
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