The Effect of Calcium Ions on hIAPP Channel Activity: Possible Implications in T2DM
The calcium ion (Ca<sup>2+</sup>) has been linked to type 2 diabetes mellitus (T2DM), although the role of Ca<sup>2+</sup> in this disorder is the subject of intense investigation. Serum Ca<sup>2+</sup> dyshomeostasis is associated with the development of insulin...
Main Authors: | Daniela Meleleo, Giuseppe Cibelli, Anna Valenzano, Maria Mastrodonato, Rosanna Mallamaci |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-11-01
|
Series: | Membranes |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0375/13/11/878 |
Similar Items
-
Melatonin Inhibits hIAPP Oligomerization by Preventing β-Sheet and Hydrogen Bond Formation of the Amyloidogenic Region Revealed by Replica-Exchange Molecular Dynamics Simulation
by: Gang Wang, et al.
Published: (2022-09-01) -
Tat-CIAPIN1 Prevents Pancreatic β-Cell Death in hIAPP-Induced RINm5F Cells and T2DM Animal Model
by: Hyeon Ji Yeo, et al.
Published: (2023-06-01) -
Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells
by: Terenzio Congiu, et al.
Published: (2021-06-01) -
Kill two birds with one stone: making multi-transgenic pre-diabetes mouse models through insulin resistance and pancreatic apoptosis pathogenesis
by: Siyuan Kong, et al.
Published: (2018-04-01) -
Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation
by: Sanduni Wasana Jayaweera, et al.
Published: (2021-03-01)