Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study
BackgroundCardiometabolic multimorbidity (CMM) has emerged as a prominent public health concern. Hypertensive patients are prone to develop comorbidities. Moreover, the accumulation of visceral adipose tissue is the main cause for the development of cardiometabolic diseases. The cardiometabolic inde...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1302296/full |
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| author | Ting Dong Weiquan Lin Qin Zhou Yunou Yang Xiangyi Liu Jiamin Chen Hui Liu Caixia Zhang |
| author_facet | Ting Dong Weiquan Lin Qin Zhou Yunou Yang Xiangyi Liu Jiamin Chen Hui Liu Caixia Zhang |
| author_sort | Ting Dong |
| collection | DOAJ |
| description | BackgroundCardiometabolic multimorbidity (CMM) has emerged as a prominent public health concern. Hypertensive patients are prone to develop comorbidities. Moreover, the accumulation of visceral adipose tissue is the main cause for the development of cardiometabolic diseases. The cardiometabolic index (CMI), lipid accumulation product (LAP), visceral adiposity index (VAI), and Chinese visceral adiposity index (CVAI) not only assess adipose tissue mass but also reflect adipose tissue dysfunction. So far, no study has been reported to evaluate the association of CMI, LAP, VAI, and CVAI with CMM risk in hypertensive patients. Therefore, this study aimed to assess the association between these adiposity indicators and the risk of CMM among Chinese hypertensive patients.MethodsIn this cross-sectional study, a total of 229,287 hypertensive patients aged 35 years and older were included from the National Basic Public Health Service Project. All participants underwent a face-to-face questionnaire survey, physical examination, and the collection of fasting venous blood samples. Multivariable logistic regression models were performed to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Receiver operating characteristic curve was utilized to evaluate the identification ability for CMM.ResultsAfter adjusting for confounders, each 1-standard deviation increase in CMI, LAP, VAI, and CVAI was associated with a 14%, 8%, 12%, and 54% increased risk of CMM, respectively. When comparing the highest quartile of these indicators with the lowest quartile, individuals in the highest quartile of CMM, LAP, VAI, and CVAI had a 1.39-fold (95% CI 1.30, 1.48), 1.28-fold (95% CI 1.19, 1.37), 1.37-fold (95% CI 1.29, 1.46), and 2.56-fold (95% CI 2.34, 2.79) increased risk of CMM after adjusting for potential confounders. Notably, a nonlinear association was observed for CMI, LAP, and VAI with the risk of CMM (all P nonlinearity < 0.001). CVAI exhibited the highest area under the receiver operating characteristic curve (AUC) among all the included adiposity indices in this analysis.ConclusionThis study indicated the significant positive association of CMI, LAP, VAI, and CVAI with the risk of CMM in hypertensive patients. Among these indicators, CVAI demonstrated the most robust performance in predicting CMM risk and may serve as a valuable tool for identifying CMM risk in Chinese hypertensive patients. |
| first_indexed | 2024-04-24T21:43:20Z |
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| language | English |
| last_indexed | 2024-04-24T21:43:20Z |
| publishDate | 2024-03-01 |
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| spelling | doaj.art-20033a97f8f8486c92e05d58354842f32024-03-21T04:29:10ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13022961302296Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional studyTing Dong0Weiquan Lin1Qin Zhou2Yunou Yang3Xiangyi Liu4Jiamin Chen5Hui Liu6Caixia Zhang7Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaDepartment of Basic Public Health, Guangzhou Center for Disease Control and Prevention, Guangzhou, ChinaDepartment of Basic Public Health, Guangzhou Center for Disease Control and Prevention, Guangzhou, ChinaDepartment of Basic Public Health, Guangzhou Center for Disease Control and Prevention, Guangzhou, ChinaDepartment of Basic Public Health, Guangzhou Center for Disease Control and Prevention, Guangzhou, ChinaDepartment of Basic Public Health, Guangzhou Center for Disease Control and Prevention, Guangzhou, ChinaDepartment of Basic Public Health, Guangzhou Center for Disease Control and Prevention, Guangzhou, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaBackgroundCardiometabolic multimorbidity (CMM) has emerged as a prominent public health concern. Hypertensive patients are prone to develop comorbidities. Moreover, the accumulation of visceral adipose tissue is the main cause for the development of cardiometabolic diseases. The cardiometabolic index (CMI), lipid accumulation product (LAP), visceral adiposity index (VAI), and Chinese visceral adiposity index (CVAI) not only assess adipose tissue mass but also reflect adipose tissue dysfunction. So far, no study has been reported to evaluate the association of CMI, LAP, VAI, and CVAI with CMM risk in hypertensive patients. Therefore, this study aimed to assess the association between these adiposity indicators and the risk of CMM among Chinese hypertensive patients.MethodsIn this cross-sectional study, a total of 229,287 hypertensive patients aged 35 years and older were included from the National Basic Public Health Service Project. All participants underwent a face-to-face questionnaire survey, physical examination, and the collection of fasting venous blood samples. Multivariable logistic regression models were performed to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Receiver operating characteristic curve was utilized to evaluate the identification ability for CMM.ResultsAfter adjusting for confounders, each 1-standard deviation increase in CMI, LAP, VAI, and CVAI was associated with a 14%, 8%, 12%, and 54% increased risk of CMM, respectively. When comparing the highest quartile of these indicators with the lowest quartile, individuals in the highest quartile of CMM, LAP, VAI, and CVAI had a 1.39-fold (95% CI 1.30, 1.48), 1.28-fold (95% CI 1.19, 1.37), 1.37-fold (95% CI 1.29, 1.46), and 2.56-fold (95% CI 2.34, 2.79) increased risk of CMM after adjusting for potential confounders. Notably, a nonlinear association was observed for CMI, LAP, and VAI with the risk of CMM (all P nonlinearity < 0.001). CVAI exhibited the highest area under the receiver operating characteristic curve (AUC) among all the included adiposity indices in this analysis.ConclusionThis study indicated the significant positive association of CMI, LAP, VAI, and CVAI with the risk of CMM in hypertensive patients. Among these indicators, CVAI demonstrated the most robust performance in predicting CMM risk and may serve as a valuable tool for identifying CMM risk in Chinese hypertensive patients.https://www.frontiersin.org/articles/10.3389/fendo.2024.1302296/fullcardiometabolic multimorbiditycardiometabolic indexlipid accumulation productvisceral adiposity indexChinese visceral adiposity indexhypertension |
| spellingShingle | Ting Dong Weiquan Lin Qin Zhou Yunou Yang Xiangyi Liu Jiamin Chen Hui Liu Caixia Zhang Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study Frontiers in Endocrinology cardiometabolic multimorbidity cardiometabolic index lipid accumulation product visceral adiposity index Chinese visceral adiposity index hypertension |
| title | Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study |
| title_full | Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study |
| title_fullStr | Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study |
| title_full_unstemmed | Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study |
| title_short | Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study |
| title_sort | association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients a large cross sectional study |
| topic | cardiometabolic multimorbidity cardiometabolic index lipid accumulation product visceral adiposity index Chinese visceral adiposity index hypertension |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1302296/full |
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