Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy
Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) being the predominant type. The roles of autophagy and apoptosis in NSCLC present a dual and intricate nature. Additionally, autophagy and apoptosis interconnect through diverse crosstalk...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1379698/full |
| _version_ | 1797230371721445376 |
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| author | Peiyi Qin Peiyi Qin Qingchen Li Qi Zu Ruxue Dong Yuanfu Qi |
| author_facet | Peiyi Qin Peiyi Qin Qingchen Li Qi Zu Ruxue Dong Yuanfu Qi |
| author_sort | Peiyi Qin |
| collection | DOAJ |
| description | Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) being the predominant type. The roles of autophagy and apoptosis in NSCLC present a dual and intricate nature. Additionally, autophagy and apoptosis interconnect through diverse crosstalk molecules. Owing to their multitargeting nature, safety, and efficacy, natural products have emerged as principal sources for NSCLC therapeutic candidates. This review begins with an exploration of the mechanisms of autophagy and apoptosis, proceeds to examine the crosstalk molecules between these processes, and outlines their implications and interactions in NSCLC. Finally, the paper reviews natural products that have been intensively studied against NSCLC targeting autophagy and apoptosis, and summarizes in detail the four most retrieved representative drugs. This paper clarifies good therapeutic effects of natural products in NSCLC by targeting autophagy and apoptosis and aims to promote greater consideration by researchers of natural products as candidates for anti-NSCLC drug discovery. |
| first_indexed | 2024-04-24T15:27:26Z |
| format | Article |
| id | doaj.art-20040b27ad974d65ae8ff9d72346f129 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T15:27:26Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-20040b27ad974d65ae8ff9d72346f1292024-04-02T05:25:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-04-011410.3389/fonc.2024.13796981379698Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategyPeiyi Qin0Peiyi Qin1Qingchen Li2Qi Zu3Ruxue Dong4Yuanfu Qi5First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShandong College of Traditional Chinese Medicine, Yantai, Shandong, ChinaDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaShandong College of Traditional Chinese Medicine, Yantai, Shandong, ChinaShandong College of Traditional Chinese Medicine, Yantai, Shandong, ChinaDepartment of Oncology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaLung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) being the predominant type. The roles of autophagy and apoptosis in NSCLC present a dual and intricate nature. Additionally, autophagy and apoptosis interconnect through diverse crosstalk molecules. Owing to their multitargeting nature, safety, and efficacy, natural products have emerged as principal sources for NSCLC therapeutic candidates. This review begins with an exploration of the mechanisms of autophagy and apoptosis, proceeds to examine the crosstalk molecules between these processes, and outlines their implications and interactions in NSCLC. Finally, the paper reviews natural products that have been intensively studied against NSCLC targeting autophagy and apoptosis, and summarizes in detail the four most retrieved representative drugs. This paper clarifies good therapeutic effects of natural products in NSCLC by targeting autophagy and apoptosis and aims to promote greater consideration by researchers of natural products as candidates for anti-NSCLC drug discovery.https://www.frontiersin.org/articles/10.3389/fonc.2024.1379698/fullautophagyapoptosiscrosstalktherapeuticsnatural productsnon-small cell lung cancer (NSCLC) |
| spellingShingle | Peiyi Qin Peiyi Qin Qingchen Li Qi Zu Ruxue Dong Yuanfu Qi Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy Frontiers in Oncology autophagy apoptosis crosstalk therapeutics natural products non-small cell lung cancer (NSCLC) |
| title | Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy |
| title_full | Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy |
| title_fullStr | Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy |
| title_full_unstemmed | Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy |
| title_short | Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy |
| title_sort | natural products targeting autophagy and apoptosis in nsclc a novel therapeutic strategy |
| topic | autophagy apoptosis crosstalk therapeutics natural products non-small cell lung cancer (NSCLC) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1379698/full |
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