Autophagy and diabetes
The current literature findings on autophagy’s beneficial and detrimental roles in diabetes mellitus (DM) and diabetes-related comorbidities were reviewed. The effects of oral hypoglycaemic medicines and autophagy in DM. Autophagy plays an important function in cellular homeostasis by promoting cell...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2023-08-01
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| Series: | Exploration of Medicine |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/em/Article/1001162 |
| _version_ | 1797691619253682176 |
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| author | Milan Obradovic Sonja Zafirovic Zoran Gluvic Jelena Radovanovic Esma R. Isenovic |
| author_facet | Milan Obradovic Sonja Zafirovic Zoran Gluvic Jelena Radovanovic Esma R. Isenovic |
| author_sort | Milan Obradovic |
| collection | DOAJ |
| description | The current literature findings on autophagy’s beneficial and detrimental roles in diabetes mellitus (DM) and diabetes-related comorbidities were reviewed. The effects of oral hypoglycaemic medicines and autophagy in DM. Autophagy plays an important function in cellular homeostasis by promoting cell survival or initiating cell death in physiological settings was also assessed. Although autophagy protects insulin-target tissues, organelle failure caused by autophagy malfunction influences DM and other metabolic diseases. Endoplasmic reticulum and oxidative stress enhance autophagy levels, making it easier to regulate stress-induced intracellular changes. Evidence suggests that autophagy-caused cell death can occur when autophagy is overstimulated and constitutively activated, which might prevent or develop DM. Even though the precise role of autophagy in DM complications is uncertain, deregulation of the autophagic machinery is strongly linked to beta cell destruction and the aetiology of DM. Thus, improving autophagy dysfunction is a possible therapeutic objective in treating DM and other metabolic disorders. |
| first_indexed | 2024-03-12T02:15:50Z |
| format | Article |
| id | doaj.art-2005b97b36ab4ba5a1c2f08b375a1d6c |
| institution | Directory Open Access Journal |
| issn | 2692-3106 |
| language | English |
| last_indexed | 2024-03-12T02:15:50Z |
| publishDate | 2023-08-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj.art-2005b97b36ab4ba5a1c2f08b375a1d6c2023-09-06T08:07:14ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062023-08-014457658810.37349/emed.2023.00162Autophagy and diabetesMilan Obradovic0https://orcid.org/0000-0002-4769-2652Sonja Zafirovic1https://orcid.org/0000-0002-5486-0079Zoran Gluvic2https://orcid.org/0000-0001-6371-6610Jelena Radovanovic3https://orcid.org/0000-0002-3005-7943Esma R. Isenovic4https://orcid.org/0000-0002-0012-2636Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Endocrinology and Diabetes, Zemun Clinical Hospital, Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, SerbiaThe current literature findings on autophagy’s beneficial and detrimental roles in diabetes mellitus (DM) and diabetes-related comorbidities were reviewed. The effects of oral hypoglycaemic medicines and autophagy in DM. Autophagy plays an important function in cellular homeostasis by promoting cell survival or initiating cell death in physiological settings was also assessed. Although autophagy protects insulin-target tissues, organelle failure caused by autophagy malfunction influences DM and other metabolic diseases. Endoplasmic reticulum and oxidative stress enhance autophagy levels, making it easier to regulate stress-induced intracellular changes. Evidence suggests that autophagy-caused cell death can occur when autophagy is overstimulated and constitutively activated, which might prevent or develop DM. Even though the precise role of autophagy in DM complications is uncertain, deregulation of the autophagic machinery is strongly linked to beta cell destruction and the aetiology of DM. Thus, improving autophagy dysfunction is a possible therapeutic objective in treating DM and other metabolic disorders.https://www.explorationpub.com/Journals/em/Article/1001162diabetesautophagyanti-hyperglycemicoxidative stress |
| spellingShingle | Milan Obradovic Sonja Zafirovic Zoran Gluvic Jelena Radovanovic Esma R. Isenovic Autophagy and diabetes Exploration of Medicine diabetes autophagy anti-hyperglycemic oxidative stress |
| title | Autophagy and diabetes |
| title_full | Autophagy and diabetes |
| title_fullStr | Autophagy and diabetes |
| title_full_unstemmed | Autophagy and diabetes |
| title_short | Autophagy and diabetes |
| title_sort | autophagy and diabetes |
| topic | diabetes autophagy anti-hyperglycemic oxidative stress |
| url | https://www.explorationpub.com/Journals/em/Article/1001162 |
| work_keys_str_mv | AT milanobradovic autophagyanddiabetes AT sonjazafirovic autophagyanddiabetes AT zorangluvic autophagyanddiabetes AT jelenaradovanovic autophagyanddiabetes AT esmarisenovic autophagyanddiabetes |